Several studies have shown a role for interleukin-1 gene cluster polymorphisms in the risk assessment for periodontal diseases. In the Study of Health in Pomerania (SHIP), 3148 subjects were randomly selected from the population and assessed for a broad range of diseases and environmental/behavioral risk factors. From the complete study group in the age 40 to 60 years, N = 1085 subjects were genotyped for the interleukin-1 genotype composite polymorphism in relation to periodontal parameters. The study objective was to elucidate the gene-environment interaction between the risk factors smoking and IL-1 polymorphism. An increased risk of periodontal disease was found for IL-1 genotype-positive smokers: odds ratio adjusted for age, sex, education, and plaque OR = 2.50 (95% C.I. 1.21 to 5.13; p = 0.013). This was not the case with subjects who never smoked: OR = 1.09 (0.73-1.62; p = 0.676). These results support the hypothesis of gene-environmental interaction in periodontitis.
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References
1.
Berger P, McConnell JP, Nunn M, Kornman KS, Sorrell J, Stephenson K, et al. -2002-. C-reactive protein levels are influenced by common IL-1 gene variants. Cytokine17:171–174.
2.
Boch JA, Wara-aswapati N, Auron PE -2001-. Interleukin 1 signal transduction—current concepts and relevance to periodontitis. J Dent Res80:400–407.
3.
Botto LD, Khoury MJ -2001-. Commentary: facing the challenge of gene-environmental interaction: the two-by-four table and beyond. Am J Epidemiol153:1016–1020.
4.
Caraballo RS, Giovino GA, Pechacek TF, Mowery PD -2001-. Factors associated with discrepancies between self-reports on cigarette smoking and measured serum cotinine levels among persons aged 17 years or older. Third National Health and Nutrition Examination Survey. 1988-1994. Am J Epidemiol153:807–814.
5.
Cattabriga M, Rotundo R, Muzzi L, Nieri M, Verrocchi G, Cairo F, et al. -2001-. Retrospective evaluation of the influence of the interleukin-1 genotype on radiographic bone levels in treated periodontal patients over 10 years. J Periodontol72:767–773.
6.
Cullinan MP, Westerman B, Hamlet SM, Palmer JE, Faddy MJ, Lang NP, et al. -2001-. A longitudinal study of interleukin-1 gene polymorphisms and periodontal disease in a general adult population. J Clin Periodontol28:1137–1144.
7.
Das I -1985-. Raised C-reactive protein levels in serum from smokers. Clin Chim Acta153:9–13.
8.
Diehl SR, Wang YF, Brooks CN, Burmeister JA, Califano JV, Wang S, et al. -1999-. Linkage disequilibrium of interleukin-1 genetic polymorphisms with early-onset periodontitis. J Periodontol70:418–430.
Engebretson SP, Lamster IB, Herrera-Abreu M, Celenti RS, Timms JM, Chaudhary AG, et al. -1999-. The influence of interleukin gene polymorphism on expression of interleukin-1beta and tumor necrosis factor-alpha in periodontal tissue and gingival crevicular fluid. J Periodontol70:567–573.
11.
Fredriksson M, Bergstrom K, Asman B -2002-. IL-8 and TNF-alpha from peripheral neutrophils and acute-phase proteins in periodontitis. J Clin Periodontol29:123–128.
12.
Graves DT -1999-. The potential role of chemokines and inflammatory cytokines in periodontal disease progression. Clin Infect Dis28:482–490.
13.
Haber J, Kent RL -1992-. Cigarette smoking in a periodontal practice. J Periodontol63:100–106.
14.
Hodge PJ, Riggio MP, Kinane DF -2001-. Failure to detect an association with IL1 genotypes in European Caucasians with generalised early onset periodontitis. J Clin Periodontol28:430–436.
15.
John U, Greiner B, Hensel E, Lüdemann J, Piek M, Sauer S, et al. -2001-. Study of Health in Pomerania -SHIP-—a health examination survey in an east German region: objectives and design. Soz Praventivmed46:186–194.
16.
Kornman KS, di Giovine FS -1998-. Genetic variations in cytokine expression: a risk factor for severity of adult periodontitis. Ann Periodontol3:327–338.
17.
Kornman KS, Crane A, Wang HY, di Giovine FS, Newman MG, Pirk FW, et al. -1997-. The interleukin-1 genotype as a severity factor in adult periodontal disease. J Clin Periodontol24:72–77.
18.
Lang NP, Tonetti MS, Suter J, Sorrell J, Duff GW, Kornman KS -2000-. Effect of interleukin-1 gene polymorphisms on gingival inflammation assessed by bleeding on probing in a periodontal maintenance population. J Periodontal Res35:102–107.
19.
McDevitt MJ, Wang HY, Knobelman C, Newman MG, di Giovine FS, Timms J, et al. -2000-. Interleukin-1 genetic association with periodontitis in clinical practice. J Periodontol71:156–163.
20.
McGuire MK, Nunn ME -1999-. Prognosis versus actual outcome. IV. The effectiveness of clinical parameters and IL-1 genotype in accurately predicting prognosis and tooth survival. J Periodontol70:49–56.
21.
Meisel P, Siegemund A, Dombrowa S, Sawaf H, Fanghaenel J, Kocher T -2001-. Smoking and polymorphisms of the interleukin-1 gene cluster -IL-1alpha, IL-1beta and IL-1RN- in patients with periodontal disease. J Periodontol73:27–32.
22.
Papapanou PN, Neiderud AM, Sandros J, Dahlén G -2001-. Interleukin-1 gene polymorphism and periodontal status. A case-control study. J Clin Periodontol28:389–396.
23.
Parkhill JM, Hennig BJ, Chapple IL, Heasman PA, Taylor JJ -2000-. Association of interleukin-1 gene polymorphisms with early-onset periodontitis. J Clin Periodontol27:682–689.
24.
Wendell KJ, Stein SH -2001-. Regulation of cytokine production in human gingival fibroblasts following treatment with nicotine and lipopolysaccharide. J Periodontol72:1038–1044.
25.
Zeidel A, Beilin B, Yardeni I, Mayburd E, Smirnov G, Bessler H -2002-. Immune response in asymptomatic smokers. Acta Anaesthesiol Scand46:959–964.
