Changes in MRI Parameters of Porcine Intervertebral Discs under Compressive Loading

Abstract

Intervertebral disc (IVD) is a major source of Low Back Pain (LBP). The health and functions of the IVD are determined by the inherent biomechanical properties and their interaction with external loading. Recent advances in quantitative Magnetic Resonance Imaging (MRI) techniques have the potential in detecting loading-induced changes in the biomechanical properties of the IVD. Twenty functional spinal units (FSU) from porcine cervical spines were imaged with a 7T scanner to obtain T_1ρ, T₂ and Apparent Diffusion Coefficient (ADC) before and after experiencing compressive loading of 263.27N for 60 minutes. Compressive loading was found to significantly decrease T_1ρ and T₂ but not ADC, which indicated that T_1ρ and T₂ had the potential to detect changes in the biomechanical properties of the IVD due to external loading. These parameters may provide more sensitivity and specificity to understand the injury mechanism of the IVD and contribute to early diagnosis of IVD degeneration.

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