Objective: To reassess previous observations regarding workplace design factors that have the greatest influence on employee perceptions of job satisfaction, and to extend the analysis to an investigation of the degree to which job satisfaction may be influenced by additional design factors. Background: Prior studies suggest that job satisfaction and occupancy quality are inextricably linked. A distinct focus of this work has been on the link between physical work environment quality and job satisfaction. Method: A 227-item survey was administered online to a total of 345 office workers employed in eight different office sites. The survey solicited respondent rankings of job satisfaction, and of levels of different attributes of occupancy quality. Results: Job satisfaction is positively correlated with productivity, and with overall employment, job, and organization quality, but not with age and with compensation and work station quality. Conclusion: Findings show mixed agreement with prior results, and also reveal new predictors of job satisfaction heretofore unrecognized. Application: Results should benefit employer decision-making regarding HF/E design interventions to improve office worker job satisfaction.