Although the diathesis-stress model guides most genetically informed behavior science, the present study investigates the hypotheses derived from the differential susceptibility perspective. This model posits that those persons most vulnerable to adverse social environments are the same ones who reap the most benefit from environmental support. Using longitudinal data from a sample of several hundred African American males, we examined the manner in which variants in 3 genes—5-serotonin transporter gene (5-HTT), dopamine receptor gene (DRD4), and monoamine oxidase gene (MAOA)—modulate the effect of community and family adversity on adoption of the street code and aggression. We found strong support for the differential susceptibility perspective.
AikenL. S.WestS. G. (1991). Multiple regression: Testing and interpreting interactions. Newbury Park, CA: SAGE.
2.
AndersonE. (1997). Violence and the inner city street code. In McCordJ. (Ed.), Violence and childhood in the inner city (pp. 1–30). New York, NY: Cambridge University Press.
3.
AndersonE. (1999). Code of the streets: Decency, violence, and the moral life of the inner city. New York, NY: Norton.
4.
AnthonyJ. M.FolsteinM.RomanoskiA. (1985). Comparison of lay diagnostic interview schedule and a standardized psychiatric diagnosis. Archives of General Psychiatry, 42, 667–675.
5.
Bakermans-KranenburgM. J.van IJzendoornM. H. (2006). Gene-environment interaction of the dompanime D4 receptor (DRD4) and observed maternal insensitivity predicting externalizing behavior in preschoolers. Developmental Psychology, 48, 406–409.
6.
Bakersmans-KranenburgM. J.van IJzendoornM. H.PijlmanF. T. A.MesmanJ.JufferF. (2008). Experimental evidence for differential susceptibility: Dopamine D4 receptor polymorphism (DRD4 VNTR) moderates intervention effects on toddlers' externalizing behavior in randomized controlled trial. Developmental Psychology, 44, 293–300.
7.
BaronS. W.KennedyL. W.FordeD. R. (2001). Male street youths' conflict: The role of background, subcultural, and situational factors. Justice Quarterly, 18, 759–789.
8.
BarrC. S.NewmanT. K.SchwandtM.ShannonC.DvoskinR. L.LindellS. G. (2004a). Sexual dichotomy of an interaction between early adversity and the serotonin transporter gene promoter variant in rehesus macaques. Proceedings of the National Academy of Science USA, 101, 12358–12363.
9.
BarrC. S.NewmanT. K.ShannonC.ParkerC.DvoskinR. L.BeckerM. L.HigleyJD. (2004b). Rearing condition and rh5-HTTLPR interact to influence limbic-hypothalamic-pituitary-adrenal axis response to stress in infant macaques. Biological Psychiatry, 55, 733–738.
10.
BeachS. R. H.BrodyG. H.LeiM. K.PhilibertR. A. (2010). Differential susceptibility to parenting among African American youths: Testing the DRD4 hypothesis. Journal of Family Psychology, 24, 513–521.
11.
BelskyJ.Bakermans-KranenburgM. J.van IJzendoornM. H. (2007). For better and for worse: Differential susceptibility to environmental influences. Current Directions in Psychological Science, 16, 3000–3004.
12.
BelskyJ.BeaverK. (2011). Cumulative-genetic plasticity, parenting, and adolescent self-regulation. Journal of Child Psychology and Psychiatry, 52, 619–626.
BentlerP. M. (1990). Comparative fit indexes in structural models. Psychological Bulletin, 107, 238–246.
15.
BradleyS. L.DodelzonK.SandhuH. K.PhilibertR. A. (2005). Relationship of serotonin transporter gene polymorphisms and haplotypes to mRNA transcription. American Journal of Medical Genetics: Part B. Neuropsychiatric Genetics, 136, 58–61.
16.
BrezinaT.AgnewR.CullenR. F.WrightJ. P. (2004). A quantitative assessment of Elijah Anderson’s subculture of violence thesis and its contribution to youth violence research. Youth Violence and Juvenile Justice, 2, 303–328.
17.
BrodyG. H.BeachS. R. H.ChenY. F.ObasiE.PhilibertR. A.KoganS. M.SimonsR. L. (2011). Perceived discrimination, serotonin transporter linked polymorphic region status, and the development of conduct problems. Development and Psychopathology, 23, 617–627.
18.
BrodyG. H.BeachS. R. H.PhilibertR. A.ChenY. F.MurryV. M. (2009). Prevention effects moderate the association of 5-HTTLPR and youth risk behavior initiation: Gene × Environment hypotheses tested via a randomized prevention design. Child Development, 80, 645–661.
19.
BrowneM. W.CudeckR. (1992). Alternative ways of assessing model fit. Sociological Methods and Research, 21, 230–258.
20.
BurtonL. M.JarrettR. L. (2000). In the mix, yet on the margins: The place of families in urban neighborhood and child development research. Journal of Marriage and Family, 63, 114–135.
21.
CarverC. S.JohnsonS. L.JoormannJ. (2008). Serotonergic function: Two-mode models of self-regulation, and vulnerability to depression: What depression has in common with impulsive aggression. Psychological Bulletin, 134, 912–943.
22.
CaoL.AdamsA.JensenV. J. (1997). A test of the black subculture of violence thesis: A research note. Criminology, 35, 367–379.
23.
CaspiA.McLayJ.MoffittT. E.MillJ.MartinJ.CraigI. W.PoultonR. (2002). Role of genotype in the cycle of violence in maltreated children. Science, 297, 851–854.
24.
CaspiA.SugdenK.MoffittT. E.TaylorA.CraigL. W.HarringtonH.PoultonR. (2003). Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science, 301, 386–389.
25.
ChampouxM.BennettA.ShannonC.HigleyJ. D.LeschK. P.SuomiS. J. (2002). Serotonin transporter gene polymorphism, differential early rearing, and behavior in rhesus monkey neonates. Molecular Psychiatry, 7, 1058–1063.
26.
CourtwrightD. T. (1996). Violent land: Single men and social disorder from the frontier to the inner city. Cambridge, MA: Harvard University Press.
27.
DeYoungC. G.PetersonJ. B.SequinJ. R.JejiaJ. M.PihlR. O.BeitchmanJ. H.PalmourR. M. (2006). The dopamine D4 receptor gene and moderation of the association between externalizing behavior and IQ. Archives of General Psychiatry, 63, 1410–1416.
28.
DreberA.ApicellaC. L.EisenbergD. T. A.GarciaJ. R.ZamoreR. S. (2009). The 7R polymorphism in the dopamine receptor D4 gene (DRD4) is associated with financial risk-taking in men. Evolution and Human Behavior, 30, 85–92.
29.
DucciF.EnochM. A.HodgkinsonC.XuK.CatenaM.RobinR. W.GoldmanD. (2008). Interaction between a functional MAOA locus and childhood sexual abuse predicts alcoholism and antisocial personality disorder in adult women. Molecular Psychiatry, 13, 334–347.
30.
EbsteinR. P. (2006). The molecular genetic architecture of human personality: Beyond self-report questionnaires. Molecular Psychiatry, 11, 427–445.
31.
EfronB.TibshiraniR. (1991). Statistical data analysis in the computer age. Science, 253, 390–395.
32.
ElliottD. S.HuizingaD.MenardS. (1989). Multiple problem youth: Delinquency, substance use, and mental health problems. New York, NY: Springer–Verlag.
33.
ElliottD. S.HuizingaD.Suzanne AgetonS. (1985). Delinquency and drug use. Beverly Hills, CA: SAGE.
34.
GibbonsF. X.GerrardM.ClevelandM. J.WillsT. A.BrodyG. (2004). Perceived discrimination and substance use in African American parents and their children: A panel study. Journal of Personality and Social Psychology, 86, 517–529.
35.
GuoG.RoettgerM. E.CaiT. (2008). The integration of genetic propensities into social-control models of delinquency and violence among male youths. American Sociological Review, 73, 569–588.
36.
FaganJ.WilkinsonD. L. (1997). Firearms and youth violence. In StoffD.BrielingJ.MaserJ. D. (Eds.), Handbook of antisocial behavior (pp. 551–567). New York: Wiley.
37.
FoleyD. L.EavesL. J.WormleyB.SibergJ. L.MaesH. H.KuhnJ.RileyB. (2004). Childhood adversity, monamine oxidase a genotype, and risk for conduct disorder. Archives of General Psychiatry, 61, 738–744.
38.
FrankM. J.MoustafaA. A.HaugheyH. M.CurranT.HutchisonK. E. (2007). Genetic triple dissociation reveals multiple roles for dopamine in reinforcement learning. Proceedings of the National Academy of Sciences of the United States of America, 104, 16311–16316.
39.
FreeseJ. (2008). Genetics and the social science explanation of outcomes. American Journal of Sociology, 114, S1–S35.
40.
FurstenbergF. F.CookT. D.EcclesJ.ElderG. H.Jr.SameroffA. (1999). Managing to make it: Urban families and adolescent success. Chicago: University of Chicago Press.
41.
HayesA. F.MatthesJ. (2009). Computational procedures for probing interactions in OLS and logistic regression: SPSS and SAS implementations. Behavior Research Methods, 41, 924–936.
42.
HeckmanJ. (1979). Sample selection bias as a specification error. Econometrica, 47, 153–161.
43.
HohmannS.BeckerK.FellingerJ.BanaschewskiT.SchmidtM. H.EsserG.LauchtM. (2009). Evidence for epistasis between the 5-HTTLPR and the dopamine D4 receptor polymorphisms in externalizing behavior among 15-year-olds. Journal of Neural Transmission, 116, 1621–1629.
44.
JarrettR. L. (1997). African American children, families, and neighborhoods: Qualitative contributions to understanding developmental pathways. Qualitative Sociology, 20, 275–288.
45.
JohnsonP. O.NeymanJ. (1936). Tests of certain linear hypotheses and their applications to some educational problems. Statistical Research Memoirs, 1, 57–93.
46.
KesslerR. C. (1991). UM-CIDI training guide for the National Survey of Health and Stress (pp. 1991–1992). Ann Arbor, MI: University of Michigan, Institute for Social Research.
47.
Kim-CohenJ.CaspiA.TaylorA.WilliamsB.NewcombeR.CraigI. W.MoffittT. E. (2006). MAOA, maltreatment, and gene–environment interaction predicting children’s mental health: New evidence and a meta-analysis. Molecular Psychiatry, 11, 903–913.
48.
LaFreeG.BaumerE. P.O’BrienR. (2010). Still separate and unequal? A city-level analysis of the black-white gap in homicide arrests since 1960. American Sociological Review, 75, 75–100.
49.
LandrineH.KlonoffE. A. (1996). Schedule of racial events: A measure of racial discrimination and a study of its negative physical and mental health consequences. Journal of Black Psychology, 22, 144–168.
50.
LeschK. P.BengelD.HeilsA.SabolS. Z.GreenbergB. D.PetriS.MurphyD. L. (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science, 274, 1527–1531.
51.
LichterJ. B.BarrC. L.KennedyJ. L.van TolH. H. M.KiddK. K.LivakK. J. (1993). A hypervariable segment in the human dopamine receptor D4 (DRD4) gene. Human Molecular Genetics, 2, 767–773.
52.
LittleT. D.CardN. A.BovairdJ. A.PreacherK. J.CrandallC. S. (2007). Structural equation modeling of mediation and moderation with contextual factors. In LittleT. D.BovairdJ. A.CardN. A. (Eds.), Modeling contextual effects in longitudinal studies (pp. 207–230). Mahwah, NJ: Lawrence Erlbaum.
53.
LuckenbillD. F.DoyleD. P. (1989). Structural position and violence: Developing a cultural explanation. Criminology, 27, 801–818.
54.
MoffittT. E.CaspiA.RutterM. (2006). Measured gene–environment interactions in psychopathology. Perspectives in Psychological Science, 1, 5–27.
55.
Morgan-LopezA. A.MacKinnonD. P. (2006). Demonstration and evaluation of a method to assess mediated moderation. Behavior Research Methods, 38, 77–87.
56.
MurphyD. L.LernerA.RudnickG.LeschK. P. (2004). Serotonin transporter: gene, genetic disorders, and pharmacogenetics. Molecular Interventions, 4, 109–123.
57.
MuthenL. K.MuthenB. O. (2010). Mplus 6.0 user’s guide. Los Angeles, CA: Muthen and Muthen.
58.
NilssonK. W.SjobergR. L.DambergM.LeppertJ.OhrvikJ.AlmP. O.OrelandL. (2006). Role of monamine oxidase A genotype and psychosocial factors in male adolescent criminal activity. Biological Psychiatry, 59, 121–127.
59.
OakJ. N.OldenhofJ.van TolH. H. M. (2000). The dopamine D4 receptor: one decade of research. European Journal of Pharmacology, 405, 303–327.
60.
OliverW. (1994). The violent social world of black men. New York, NY: Lexington Books.
61.
OliverW. (2006). The streets: An alternative black male socialization institution. Journal of Black Studies, 36, 918–937.
62.
OuseyG.WilcoxP. (2005). Subcultural values and violent delinquency: A multilevel analysis in middle schools. Youth Violence and Juvenile Justice, 3, 1–20.
63.
Pauli-PottU.FriedlS.HinneyA.HebebrandJ. (2009). Serotonin transporter gene polymorphism (5-HTTLPR) environmental conditions, and developing negative emotionality and fear in early childhood. Journal of Neural Transmission, 116, 503–512.
64.
PetersonR. D.KrivoL. J.HaganJ. (2006). The many colors of crime. New York: New York University Press.
65.
PreacherK. J.CurranP. J.BauerD. J. (2006). Computational tools for probing interaction effects in multiple linear regression, multilevel modeling, and latent curve analysis. Journal of Educational and Behavioral Statistics, 31, 437–448.
66.
PropperC.WilloughbyM.HalpernC. T.CarboneM. A.CoxM. (2007). Parenting quality, DRD4, and the prediction of externalizing and internalizing behaviors in early childhood. Developmental Psychobiology, 49, 619–632.
67.
ReifA.RoslerM.FreitagC. M.SchneiderM.EujenA.KisslingC.RetzW. (2007). Nature and nurture predispose to violent behavior: Serotonergic genes and adverse childhood environment. Neuropsychopharmacology, 32, 2375–2383.
68.
RetzW. G.FreitagC. M.Retz-JungingerP.WenzlerD.SchneiderM.KisslingC.RöslerM. (2008). A functional serotonin transporter promoter gene polymorphism increases ADHD symptoms in delinquents: Interaction with adverse childhood environment. Psychiatry Research, 158, 123–131.
69.
RobbinsT. W.EverittB. J. (1999). Motivation and reward. In ZigmondM. J.BloomF. E.LandisC.RobertsJ. L.SquireL. R. (Eds.), Fundamental neuroscience (pp. 1246–1260). San Diego, CA: Academic Press.
70.
RobinsL. N.RegierD. A. (1991). Psychiatric disorders in America: The epidemiologic catchment area study. New York: Free Press.
71.
RutterM.MoffittT. E.CaspiA. (2006). Gene-environment interplay and psychopathology: Multiple varieties but real effects. Journal of Child Psychology and Psychiatry, 47, 226–251.
72.
SabolS. Z.HuS.HamerD. (1998). A functional polymorphism in the monoamine oxidase A gene promoter. Human Genetics, 103, 273–279.
73.
SampsonR. J.MorenoffJ. D.RaudenbushS. W. (2005). Social anatomy of racial and ethnic disparities in violence. American Journal of Public Health, 95, 224–232.
74.
SampsonR. J.RaudenbushS. W.EarlsF. (1997). Neighborhoods and violent crime: A multilevel study of collective efficacy. Science, 277, 918–924.
75.
SchmidtL. A.FoxN. A.RubinK. H.HuS.HamerD. H. (2002). Molecular genetics of shyness and aggression in preschoolers. Personality and Individual Differences, 22, 227–238.
76.
SchwandtM.LindellS. G.SjobergR. L.ChisholmK. L.HigleyJ. D.SuomiS. J.BarrC. S. (2010). Gene–environment interactions and response to social intrusion in male and female rhesus macaques. Biological Psychiatry, 67, 323–330.
77.
ShanahanM.HoferS. M. (2005). Social context in gene–environment interactions: Retrospect and prospect. Journal of Gerontology B: Psychological and Social Science, 60, 65–76.
78.
ShanahanM.HoferS. M. (2011). Molecular genetics, aging, and well-being: Sensitive period, accumulation, and pathway models. In BinstockR. H.GeorgeL. K. (Eds.), Handbook of aging and the social sciences. (7th ed.)
New York: Elsevier.
79.
ShihJ. C.ChenK.RiddM. J. (1999). Monoamine oxidase: From genes to behavior. Annual Review of Neuroscience, 22, 197–217.
80.
SimonsR. L.BurtC. B. (2011). Learning to be bad: Adverse conditions, social schemas, and crime. Criminology, 49, 553–598.
81.
SimonsR. L.ChenY. F.StewartE. A.BrodyG. H. (2003). Incidents of discrimination and risk for delinquency: A longitudinal test of strain theory with an African American sample. Justice Quarterly, 20, 827–854.
82.
SimonsR. L.LeiM. K.BrodyG. H.BeachS. R. H.PhilibertR. A.GibbonsF. X. (in press). Social environmental variation, plasticity genes, and antisocial behavior: Evidence for the Differential Susceptibility Hypothesis. American Sociological Review.
83.
SimonsR. L.LinK. H.GordonL. C.BrodyG. H.MurryV.CongerR. D. (2002). Community contextual differences in the effect of parental behavior on child conduct problems: A multilevel analysis with an African American sample. Journal of Marriage and Family, 64, 331–345.
84.
SimonsR. L.SimonsL. G.BurtC. H.DrummundH.StewartE.BrodyG. H. (2006). Supportive parenting moderates the effect of discrimination upon anger, hostile view of relationships, and violence among African American boys. Journal of Health and Social Behavior, 47, 373–389.
85.
SimonsR. L.SimonsL. G.ChenY. F.BrodyG. H.LinK. H. (2007). Identifying the psychological factors that mediate association between parenting practices and delinquency. Criminology, 45, 481–517.
86.
StewartE. A.SimonsR. L. (2006). Structure and culture in African-American adolescent violence: A partial test of the code of the street thesis. Justice Quarterly, 23, 1–33.
87.
StewartE. A.SimonsR. L. (2010). Race, code of the street, and violent delinquency: A multilevel investigation of neighborhood street culture and individual norms of violence. Criminology, 48, 569–606.
88.
SullivanM. I. (1989). “Getting Paid”: Youth crime and work in the Inner City. Ithaca, NY: Cornell University.
89.
UnneverJ. D.CullenF. T.MathersS. A.McClureT. E.AllisonM. C. (2009). Racial discrimination and Hirschi’s criminological classic: A chapter in the sociology of knowledge. Justice Quarterly, 26, 377–409.
90.
VeronaE. J.JohnsonT. E.JohnsonF.BenderT. W. (2006). Gender specific gene–environment interactions on laboratory-assessed aggression. Biological Psychiatry, 71, 33–41.
91.
VélezM. B. (2001). The role of public social control in urban neighborhoods: A multilevel analysis of victimization risk. Criminology, 39, 837–864.
92.
WidomC. S.BrzusowiczL. M. (2006). MAOA and the “cycle of violence”: Childhood abuse and neglect, MAOA genotype, and risk for violent and antisocial behavior. Biological Psychiatry, 60, 684–689.
93.
WilkinsonD. L. (2003). Guns, violence, and identity among African American and Latino youth. New York: LFB Scholarly Publishing.
