The smooth muscle contractile properties of 100 human saphenous veins derived from healthy tissue and organ donors were investigated. No significant changes in the contractile responses of saphenous veins to potassium chloride, serotonin, and norepinephrine were associated with age. In contrast, comparison of contractile responses between males and females demonstrated significantly less response to potassium chloride in female veins (P<0.05). Female contractile responses to serotonin (P=0.74) and norepinephrine (P= 0.29) did not differ significantly when compared with male responses. These observations support the conclusion that gender may be an important variable in saphenous vein biology.
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References
1.
1. Brockbank KGM, Harris SJ, Nardiello J, et al: Evaluation of a simplified saphenous vein procurement technique. J Transpl Coord3:39-43, 1993.
2.
2. Panetta TF, Marin ML, Veith FJ, et al: Unsuspected preexisting saphenous vein disease: An unrecognized cause of vein bypass failure. J Vasc Surgl5:102-112, 1992.
3.
3. Marin ML, Veith FJ, Panetta TF, et al: Saphenous vein biopsy: A predictor of vein graft failure. J Vasc Surg18:407-415, 1993.
4.
4. Schwartz LB, Radic ZS, O'Donohoe MK, et al: Saphenous vein endothelium-dependent relaxation in patients with peripheral vascular disease. Ann Vasc Surg6:425-432, 1992.
5.
5. Brockbank KGM, Bank HL, Schmehl M: Ischemia and saphenous vein endothelial integrity. Transpl Proc21:1384-1388, 1989.
6.
6. Harker CT, Ousley PJ, Harris J, et al: The effects of cooling on human saphenous vein reactivity to adrenergic agonists. J Vasc Surg12:45-49, 1990.
7.
7. Cross KS, Davies MG, El-Sanadiki MN, et al: Long-term vein graft contractility and morphology: A functional and histopathological study of retrieved coronary vein grafts. Br J Surg (in press), 1994.
8.
8. Park TC, Bowman C, Harker CT, et al: Human saphenous veins grafted into arterial circulation demonstrate altered smooth muscle and endothelial responses. J Vasc Surg15:1068-1068 (abstract), 1992.
9.
9. Torok J, Kristek F, Mokrasova M: Endothelium-de-pendent relaxation in rabbit aorta after cold storage. Eur J Pharmacol228:313-319, 1993.
10.
10. Karatapanis S, McCormick PA, Stansby J, et al: Effects of liver and kidney preservation solutions on vascular viability: Studies on contraction and relaxation of rat aorta in vitro. Transpl Proc25:2148-2152, 1993.
11.
11. Chan BBK, Kron IL, Flanagan TL, et al: Impairment of vascular endothelial function by high-potassium storage solutions. Ann Thorac Surg55:940-945, 1993.
12.
12. Davies MG, Brockbank KGM, Hagen P-O: The relationship of human saphenous vein intimal area to age and gender. Vasc Surg26:700-704, 1992.
13.
13. Cross KS, El-Sanadiki MN, Murray JJ, et al: Functional abnormalities of experimental autogenous vein graft neoendothelium. Ann Surg208:631-638, 1988.
