The possible healing effect of deferoxamine and pentoxifylline on persisting lower limb ulcers was studied in 51 patients with thalassemia major.
The results indicated that the regular use of deferoxamine at an intravenous dose of 20 mg/kg did not affect the healing progress and the recurrence rate of these ulcers significantly On the contrary, the oral administration of pentoxifylline at a dose of 1,200 mg daily during the ulcer's healing time and at a low long-term maintenance dose of 400 mg daily during the ulcer-free intervals improved their healing ability impressively and diminished their recurrence rate significantly
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References
1.
Pascher F., Keen R.: Ulcer of the legs in Cooley's anemia. N Engl J Med256:1220-1222, 1957.
2.
Samitz MH, Waldorf DS, Shrager J.: Leg ulcers in Mediterranean anemia. Arch Dermatol90:567-571, 1964.
3.
Stevens RM, Shupak JL, Javid J., et al: Ulcers of the leg in thalassemia. Arch Dermatol113:1558-1560, 1977.
4.
Angelkort B. , Maurin N., Boateng K.: Influence of pentoxifylline on erythrocyte deformability in peripheral occlusive arterial disease. Curr Med Res Opin6:255-258, 1979.
5.
Buchanan N., Moodley GP: The effect of pentoxifylline on human erythrocyte adenosine triphosphate . IRCS Med Sci5:43, 1977.
6.
Ehrly AM: The effect of pentoxifylline on the deformability of erythrocytes and on the muscular oxygen pressure in patients with chronic arterial disease . J Med10:331-338, 1979.
7.
Smud R., Sermukslis B., Kartin O.: Changes in blood viscosity induced by pentoxifylline. Pharmatherapeutica1:229-233, 1976.
8.
Weithermann KU: The influence of pentoxifylline on interactions between blood vessel wall and platelets. IRCS Med Sci8:293-294, 1980.
9.
Angelides NS : Continuous infusion treatment with pentoxifylline in patients with severe peripheral vascular occlusive disease. Angiology8:555-564, 1986.
10.
Seiffge D., Berthold R., Berthold F.: Effect of pentoxifylline on sickle cell thalassaemia: Haemorheological and clinical results. Klin Wochenschr61:1159-1160, 1983.
11.
Angelides NS , Weil von der Ahe CA: Effect of oral pentoxifylline therapy on venous lower extremity ulcers due to deep venous incompetence. Angiology40:752-763, 1989.
12.
Muller R.: On therapy of disturbances of blood fluidity. Angiology36:226-234, 1985.
13.
Schröer R.: Antithrombotic potential of pentoxifylline—a haemorheologically active drug. Angiology36:387-398, 1985.
14.
Angelides NS , Weil von der Ahe CA, Themistocleus P.: Comparison of skin and muscle biopsies before and after pentoxifylline treatment in patients with leg ulcers due to deep venous incompetence. Int Angiology10:72-76, 1991.
