Clinical and Morphologic Assessment of Long-Term Human Umbilical Cord Vein Implants Employed as Vascular Conduits

Abstract

Clinical experience employing glutaraldehyde-stabilized human umbilical cord veins as vascular prostheses for popliteal, tibial, and peroneal recon structions continues to show promise and remarkable morphologic stability for periods exceeding 4 years. Cumulative graft patency rates are similar to those achieved with autologous saphenous vein. Angiographic studies as well as analysis of explant specimens by microscopy and biophysical techniques demonstrate the durability of these protheses. Although some changes do occur, such as lipid imbibition, these may reflect the metabolic status of the host more than the graft itself.