Treatment with streptokinase followed by heparin was compared on a randomized basis with treatment with heparin alone in patients with acute pulmonary embolism. The diagnosis and results of treatment were established by pulmonary angiography. Fifteen patients received streptokinase and 16 received heparin alone. Complications included bleeding and pyrexia in both treatment groups and anaphylaxis in a patient receiving streptokinase. There were three deaths attributed to the disease its treatment. Patients in the strepto kinase group had significantly greater angiographic improvement (P = 0.0125) than those in the heparin group.
Tibbutt, D.A. , Davis, J.A., Anderson , J.A., et al: Comparison by control clinical trial of streptokinase and heparin in treatment of life-threatening pulmonary embolism . Br. Med. J.1: 343-347, 1974.
4.
Marder, V.J. , Soulen, R.L., Atichartakarn , V., et al.: Quantitative venographic assessment of deep vein thrombosis in the evaluation of streptokinase and heparin therapy. J Lab. Clin. Med., 89: 1018, 1977 .
5.
Seaman, A.J. : Evaluation of thrombolytic agents, in Principles and Techniques of Human Research and Therapeutics. Edited by F. A. McMahon. Mt. Kisco, NY , Futura Publishing Company, 1974 , pp. 155-166.
6.
Seaman, A.J. , Common, H.H., Rösch , J., et al.: Deep vein thrombosis treated with streptokinase or heparin: A randomized study. Angiology, 27: 549-556, 1976.
7.
Rösch, J., Dotter, C.T., Seaman, A.J., et al.: Healing of deep venous thrombosis: Venographic findings in a randomized streptokinase versus heparin study. Am. J. Roentgenol. Radium Ther. Nucl. Med., 127: 553-558, 1976.
