Rupture of an aneurysm in a patient suffering from neurofibromatosis is a rare though documented complication. Presented here is the case of a 33-year-old woman with known neurofibromatosis who underwent repair of a symptomatic popliteal aneurysm. The presentation, diagnostic evaluation, and treatment are discussed, and the literature is reviewed on this rare entity.
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References
1.
Riccardi VM: von Recklinghausen neurofibromatosis. N Engl J Med305:1617-1627, 1991.
2.
Schievink WI, Michels VV, Piepgras DG: Neurovascular manifestations of heritable connective tissue disorders. A Review. Stroke25:8889-8903, 1994.
3.
Von Recklinghausen F: Ubre die multiplen fibrome der Aut. Und ihre beziehung zu den multiplen neuromen. Berlin, 9 Hirschwald, 1882.
4.
Riccardi VM: Neurofibromatosis: Phenotype, Natural History and Pathogenesis, ed. 2. Baltimore: The Johns Hopkins University Press, 1992.
5.
Hamilton SJ, Friedman JM: Insights into the pathogenesis of neurofibromatosis. 1. Vasculopathy. Clin Genet58:341-347, 2000.
6.
Gutmann DH, Collins FS: The neurofibromatosis type 1 gene and its protein product, neurofibromin. Neuron10:335-343, 1993.
7.
Reubi F: Neurofibromatose et lesions vasculaires. Schweiz Med Wschr75:463-465, 1945.
8.
Itzchak Y, Katznelson D, Boichis H, et al: Angiographic features of arterial lesions in neurofibromatosis. Am J Roentgenol122:643-647, 1974.
Salyer WR, Salyer DC: The vascular lesions of neurofibromatosis. Angiology25:510-519, 1974.
11.
Brasdield RD, Gupta TKD: Von Recklinghausen's disease: A clinicopathological study. Ann Surg175:86-86, 104-104, 1972.
12.
Feyrter F: Ubre die vasculare neurofibromatose, nach utersuchlungen am menschlichen magendarmschlauch. Virchow Arch Path Anat 317:221, 1949.
13.
Greene JF, Fitzwater JE, Burgess J: Arterial lesions associated with neurofibromatosis. Am J Clin Pathol62:481-487, 1974.
14.
Morello F, Shah P, Dowling K, et al: A hemorrhagic complication of neurofibromatosis. J Vasc Interv Radiol12:773-774, 2001.
15.
Wigger P, Stierli P, Satamm B: Replacement of the abdominal aorta in a young patient with neurofibromatosis and massive retroperitoneal haemorrhage. Eur J Vasc Endovasc Surg13:337-339, 1997.
16.
Kousseff BG, Gilbert-Barness EF: “Vascular neurofibromatosis” and infantile gangrene. Am J Med Genet34:221-226, 1989.
17.
Van Damme H, Deprez M, de Leval L, et al: Aneurysme femoral superficiel rompu dans le cadre d'une neurofibromatose. A propos d'un cas. J Mal Vasc 19: 62-65, 1994.
18.
Craddock GR, Challa VR, Dean HD: Neurofibromatosis and renal artery stenosis: A case of familiar incidence. J Vasc Surg8:489-494, 1988.
19.
Smith CJ, Hatch FE, Johson JG, et al: Renal artery dysplasia as a cause of hypertension in neurofibromatosis. Arch Intern Med125:1022-1026, 1970.
Zochodne DM: Von Recklinghausen's vasculopathy. Am J Med Sci287:64-65, 1984.
23.
Rowen M, Dorsey TJ, Kegel SM: Thoracic coarctation associated with neurofibromatosis. Am J Dis Child129:113-115, 1975.
24.
Bourke E, Gatenby PBB, Renal artery dysplasia with hypertension in neurofibromatosis. BMJ3:681-682, 1971.
25.
Halpern M, Currarino G: Vascular lesions causing hypertension in neurofibromatosis. N Engl J Med273: 248-252, 1965.
26.
Craddock GR, Challa VR, Dean RH: Neurofibromatosis and renal artery stenosis: A case of familial incidence. J Vasc Surg8:489-494, 1988.
27.
Debure C, Fiessinger JN, Bruneval P, et al: LÈsions artÈrielles multiples au cours de la maladie de von Recklinghausen. Une observation. Presse MÈd 13:1776-1778, 1984.
28.
Faggioli GL, Gargiulo M, Bertoni F, et al: Hypertension due to an aneurysm of the left renal artery in a patient with neurofibromatosis. Ann Vasc Surg6: 456-459, 1992.
29.
Bradley WG, Darhoff RB, Fernichel GM, et al: Diseases associated with autosomal inheritance. Neurofibromatosis 1 and neurofibromatosis 2. In: Neurology in Clinical Practice, vol. II. Stoneham, MA: Butterworths, 1991, pp 1324-1327, 1342-1342.
30.
Hassen-Khodja R, Declemy S, Batt M, et al: Visceral artery aneurysms in von Recklinghausen's neurofibromatosis. J Vasc Surg25:572-575, 1997.
31.
Huffman JL, Gahtan V, Bowers VD, et al: Neurofibromatosis and arterial aneurysms. Am Surg62:311-314, 1996.
32.
Fye KH, Jacobs RP, Roe RL: Vascular manifestations of von Relinghausen's disease. West J Med122:110-116, 1975.
33.
Sobata E, Ohkuma H, Suzuki S: Cerebrovascular disorders associated with von Recklinghausen's neurofibromatosis: A case report. Neurosurg22:544-549, 1988.
34.
Smith BL, Munschauer CE, Diamond N, et al: Ruptured internal carotid aneurysm resulting from neurofibromatosis: Treatment with intraluminal stent graft. J Vasc Surg32:824-828, 2000.
35.
Magara T, Onoe M, Yamamoto Y, et al: Massive mediastinal bleeding due to spontaneous rupture of the vertebral artery in von Recklinghausen's disease. Jpn J Torca Cardiovasc Surg46:906-909, 1998.
36.
Takahaschi K, Maruyama A, Ainai S, et al: A case of ruptured left subclavian artery associated with von Recklinghausen's disease. Kyobu Geka42:1036-1038, 1989.
37.
Shimizu Y, Tanaka T, Nakae A, et al: A case of spontaneous rupture of bilateral lumbar artery in a patient with von Recklinghausen disease. Nippon Geka Gakkai Zasshi94:420-423, 1993.
38.
Sayito S, Matsuda S: Aneurysm of the major vessels in neurofibromatosis. Arch Orthop Trauma Surg117:110-113, 1998.
39.
Tidwell C, Copas P: Brachial artery rupture complicating a pregnancy with neurofibromatosis: A case report. Am J Obstet Gynecol179:832-834, 1998.
40.
Grey AC, Vallelly SR: Spontaneous false aneurysm of the radial artery in neurofibromatosis. Clinical Radiology54:185-196, 1999.
41.
Myers JL, Losseff SV, gomes MN: Surgical repair of an aneurysm of the Arc of Buhler in a patient with von Recklinghausen's disease. Eur J Vasc Endovasc Surg16:540-542, 1998.
42.
Young LP, Stanley A, Menzoian JO: An anterior tibial artery aneurysm in a patient with neurofibromatosis. J Vasc Surg33:114-117, 2001.
43.
Kwong KL, Wong YC: Moyamoya disease in a child with neurofibromatosis type-1. J Paediatr Child Health35:108-109, 1999.
44.
Siquiera Neto JI, Silva GS, De Castro JD, et al: Neurofibromatosis associated with moyamoya arteriopathy and fusiform aneurysm: Case report. Arq Neuropsiquiatr56:819-823, 1998.
45.
Inoguchi H, Mii S, Sakata H, et al: Critical limb ischemia in a patient with von Recklinghausen's Neurofibromatosis. J Cardiovasc Surg41:627-629, 2000.
46.
Ilgit ET, Vural M, Oguz A, et al: Peripheral arterial involvement in neurofibromatosis type 1. A case report. Angiology50:955-958, 1999.
47.
Smith MAP, White JAM: Ruptured cervical aneurysm with neurofibromatosis. S Afr Med J48:945-946, 1974.
