Allergic reactions to beta-lactams, such as penicillin, can be life-threatening. Due to
the large number of individuals allergic to beta-lactams, a method for their inactivation
was explored such that a contaminated area could be treated and re-used. The goal was to
validate a cycle that could be used to treat a pharmaceutical manufacturer's beta-lactam
manufacturing equipment for the future production of non-beta-lactam compounds. Testing
was conducted using chlorine dioxide gas at various concentrations and exposure times in
an effort to achieve the pharmaceutical manufacturer's required 3-log (99.9%) reduction of
eight different beta-lactams on various surfaces. After a period of cycle development,
multiple chlorine dioxide gas cycles at various concentrations and exposure lengths were
shown effective in inactivating the eight beta-lactam compounds to a successful
degree.
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