The present study compares the efficacy of various disinfectants against Bacillus
anthracis spores. While Bleach Rite® and 10% bleach reduce spore numbers by 90% within 10
minutes, a long contact time is required for complete disinfection. By contrast, although
SporGon® did not initially reduce the number of spores as quickly as Bleach Rite or 10%
bleach, shorter contact times were required for complete eradication of viable spores.
References
1.
ButtnerM. P., CruzP., StetzenbachL. D., Klima-CombaA. K., StevensV. L., & CroninT.
D. (2004). Determination
of the efficacy of two building decontamination strategies by surface sampling with
culture and quantitative PCR analysis. Applied and Environmental
Microbiology, 70(8), 4740–4747.
2.
CanterD. A., GunningD., RodgersP., O'ConnorL., TrauneroC., & KempterC.
J. (2005). Remediation
of Bacillus anthracis contamination in the U.S. Department of Justice mail
facility. Biosecurity and Bioterrorism, 3(2), 119–127.
3.
Current Technologies, Inc.. Bleach Rite Disinfecting Spray with bleach. Material Safety Data Sheet (pp.
1–3).
4.
Current Technologies, Inc. (2006). Bleach Rite Disinfecting Spray. Caledonia, MI: Market
Labs.
5.
Decon Laboratories, Inc. (2006). SporGon high level disinfectant sterilizing
solution. Technical Data Sheet.
6.
Decon Laboratories, Inc. (2001). Sporgon, sporicidal disinfectant. Material Safety Data Sheet.
7.
DyasA., & DasB.
C. (1985). The
activity of glutaraldehyde against Clostridium difficile. The
Journal of Hospital Infection, 6(1), 41–45.
8.
HeningerS., DrysdaleM., LovchikJ., HuttJ., LipscombM. F. & KoehlerT.
M. (2006).
Toxin-deficient mutants of Bacillus anthracis are lethal in a murine
model for pulmonary anthrax. Infection and Immunity, 74(11), 6067–6074.
9.
KenarL., OrtatatliM., YarenH., KarayilanogluT., & AydoganH. (2007). Comparative sporicidal effects of disinfectants
after release of a biological agent. Military Medicine, 172(6), 616–621.
10.
KolbR.
W., & SchneiterR. (1950). The germicidal and sporicidal efficacy of methyl
bromide for Bacillus anthracis. Journal of
Bacteriology, 59(3), 401–412.
11.
MajcherM. R., BernardK. A., & SattarS.
A. (2008).
Identification by quantitative carrier test of surrogate spore-forming
bacteria to assess sporicidal chemicals for use against Bacillus
anthracis. Applied and Environmental Microbiology, 74(3), 676–681.
12.
MancheeR. J., BrosterM. G., AndersonI. S., HenstridgeR.
M., & MellingJ. (1983). Decontamination of Bacillus anthracis on Gruinard
Island?. Nature, 303, 239–240.
MoranG.
J. (1999). Update on
emerging infections from the Centers for Disease Control and Prevention. Bioterrorism
alleging use of anthrax and interim guidelines for management–United States,
1998. Annals of Emergency Medicine, 34(2), 229–232.
15.
PerezJ., SpringthorpeV.
S., & SattarS.
A. (2005). Activity of
selected oxidizing microbicides against the spores of Clostridium difficile: Relevance
to environmental control. American Journal of Infection
Control, 33(6), 320–325.
16.
RogersJ. V., ChoiY. W., RichterW. R., RudnickiD. C., JosephD. W. & SabourinC.
L. (2007).
Formaldehyde gas inactivation of Bacillus anthracis, Bacillus subtilis,
and Geobacillus stearothermophilus spores on indoor surface materials. Journal of Applied Microbiology, 103(4), 1104–1112.
17.
RogersJ. V., SabourinC. L., ChoiY. W., RichterW. R., RudnickiD. C. & RiggsK.
B. (2005).
Decontamination assessment of Bacillus anthracis, Bacillus subtilis, and
Geobacillus stearothermophilus spores on indoor surfaces using a hydrogen peroxide gas
generator. Journal of Applied Microbiology, 99(4), 739–748.
18.
RutalaW. A., ColeE. C., ThomannC. A., & WeberD.
J. (1998). Stability and
bactericidal activity of chlorine solutions. Infection Control
and Hospital Epidemiology, 19(5), 323–327.
19.
SagripantiJ. L., CarreraM., InsalacoJ., ZiemskiM., RogersJ., & ZandomeniR. (2007). Virulent spores of Bacillus anthracis and other
Bacillus species deposited on solid surfaces have similar sensitivity to chemical
decontaminants. Journal of Applied Microbiology, 102(1), 11–21.