Abstract
Eliminating environmental or other airborne contaminants in medical, biological research and production facuities is critical to the success of their mission (Sansone & Losikoff, 1977; Walters & Ryan, 2001). In situ measurement of environmental conations creates a potential for inhalation hazards. Use of computational fluid dynamics (CFD), allows for a non-intrusive way of determining the room air conditions without concern for operator safety. The goal of this study is to use CFD computer modeling to study a pharmaceutical clean-room environment in which there has been an accidental introduction of aerosolized contaminant. The concentration and distribution of the contaminant is determined throughout the room for a range of conations, by computation using three mathematical models and also experimentally field deter-mined. A comparison of best fit shows High Reynolds number k-∊ model calculations are most practical from a computational and prediction standpoint.