AleksunesLMReismanSAYeagerRLGoedkenMJKlaassenCD.Nuclear factor erythroid 2-related factor 2 deletion impairs glucose tolerance and exacerbates hyperglycemia in type 1 diabetic mice. J Pharmacol Exp Ther2010;
333:140–51
2.
CopleyKMcCowenKHilesRNielsenLLYoungAParkesDG.Investigation of exenatide elimination and its in vivo and in vitro degradation. Curr Drug Metab2006;
7:367–74
3.
JuangJHKuoCHWuCHJuangC.Exendin-4 treatment expands graft beta-cell mass in diabetic mice transplanted with a marginal number of fresh islets. Cell Transplant2008;
17:641–7
4.
LimYARheinVBaysangGMeierFPoljakARafteryMJGuilhausMIttnerLMEckertAGotzJ.Abeta and human amylin share a common toxicity pathway via mitochondrial dysfunction. Proteomics2010;
10:1621–33
5.
CurtinJFDonovanMCotterTG.Regulation and measurement of oxidative stress in apoptosis. J Immunol Methods2002;
265:49–72
6.
ZraikaSHullRLUdayasankarJAston-MourneyKSubramanianSLKisilevskyRSzarekWAKahnSE.Oxidative stress is induced by islet amyloid formation and time-dependently mediates amyloid-induced beta cell apoptosis. Diabetologia2009;
52:626–35
7.
HsiehCCPapaconstantinouJ.Thioredoxin-ASK1 complex levels regulate ROS-mediated p38 MAPK pathway activity in livers of aged and long-lived Snell dwarf mice. FASEB J2006;
20:259–68
8.
LiuYMinW.Thioredoxin promotes ASK1 ubiquitination and degradation to inhibit ASK1-mediated apoptosis in a redox activity-independent manner. Circ Res2002;
90:1259–66
ShenHMLiuZG.JNK signaling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species. Free Radic Biol Med2006;
40:928–39
ItohKIgarashiKHayashiNNishizawaMYamamotoM.Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins. Mol Cell Biol1995;
15:4184–93
13.
ItohKChibaTTakahashiSIshiiTIgarashiKKatohYOyakeTHayashiNSatohKHatayamaIYamamotoMNabeshimaY.An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem Biophys Res Commun1997;
236:313–22
14.
IshiiTItohKTakahashiSSatoHYanagawaTKatohYBannaiSYamamotoM.Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. J Biol Chem2000;
275:16023–9
15.
InnamoratoNGRojoAIGarcía-YagüeÁJYamamotoMde CeballosMLCuadradoA.The transcription factor Nrf2 is a therapeutic target against brain inflammation.J Immunol2008;
181:680–9
16.
HitchonCAEl-GabalawyHS.Oxidation in rheumatoid arthritis. Arthritis Res Ther2004;
6:265–78
17.
MatteucciEMalvaldiGFagnaniFEvangelistaIGiampietroO.Redox status and immune function in type I diabetes families. Clin Exp Immunol2004;
136:549–54
18.
Alexsandra da Silva Neto TrajanoLda SilvaCLde CarvalhoSNCortezEMencalhaALde Souza da FonsecaAStumboAC.Cell viability, reactive oxygen species, apoptosis, and necrosis in myoblast cultures exposed to low-level infrared laser. Lasers Med Sci2016;
31:841–8
19.
CircuMLAwTY.Reactive oxygen species, cellular redox systems and apoptosis. Free Radical Biol Med2010;
48:749–62
20.
HiguchiMHondaTProskeRJYehET.Regulation of reactive oxygen species-induced apoptosis and necrosis by caspase 3-like proteases. Oncogene1998;
17:2753–60
21.
ZhangAYYiFZhangGGulbinsELiPL.Lipid raft clustering and redox signaling platform formation in coronary arterial endothelial cells. Hypertension2006;
47:74–80
22.
ZhangAYYiFJinSXiaMChenQZGulbinsELiPL.Acid sphingomyelinase and its redox amplification in formation of lipid raft redox signaling platforms in endothelial cells. Antioxid Redox Signal2007;
9:817–28
23.
BarnhartBCAlappatECPeterME.The CD95 type I/type II model. Semin Immunol2003;
15:185–93
24.
KelekarAThompsonCB.Bcl-2-family proteins: the role of the BH3 domain in apoptosis. Trends Cell Biol1998;
8:324–30
25.
AshinoTYamamotoMNumazawaS.Nrf2/Keap1 system regulates vascular smooth muscle cell apoptosis for vascular homeostasis: role in neointimal formation after vascular injury. Sci Rep2016;
6:26291
26.
EnomotoAItohKNagayoshiEHarutaJKimuraTO'ConnorTHaradaTYamamotoM.High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes. Toxicol Sci2001;
59:169–77
27.
Ramos-GomezMKwakMKDolanPMItohKYamamotoMTalalayPKenslerTW.Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc Natl Acad Sci USA2001;
98:3410–5
28.
ChoHYJedlickaAEReddySPKenslerTWYamamotoMZhangLYKleebergerSR.Role of NRF2 in protection against hyperoxic lung injury in mice. Am J Respir Cell Mol Biol2002;
26:175–82
29.
BruntKRFenrichKKKianiGTseMYPangSCWardCAMeloLG.Protection of human vascular smooth muscle cells from H2O2-induced apoptosis through functional codependence between HO-1 and AKT. Arterioscler Thromb Vasc Biol2006;
26:2027–34
30.
TaguchiKFujikawaNKomatsuMIshiiTUnnoMAkaikeTMotohashiHYamamotoM.Keap1 degradation by autophagy for the maintenance of redox homeostasis. Proc Natl Acad Sci USA2012;
109:13561–6
31.
AshinoTYamamotoMNumazawaS.Nrf2/Keap1 system regulates vascular smooth muscle cell apoptosis for vascular homeostasis: role in neointimal formation after vascular injury. Sci Rep2016;
6:26291
32.
LeeJKangJSBa NamLYooOKKeumYS.Suppression of NRF2/ARE by convallatoxin sensitizes A549 cells to 5-FU-mediated apoptosis. Free Radic Res2018;10:1–8
33.
LiQLiBLiuCWangLTangJHongL.Protective role of Nrf2 against mechanical-stretch-induced apoptosis in mouse fibroblasts: a potential therapeutic target of mechanical-trauma-induced stress urinary incontinence. Int Urogynecol J2018;29:1469–77.
34.
YanLJFanXWYangHTWuJTWangSLQiuCG.MiR-93 inhibition ameliorates OGD/R induced cardiomyocyte apoptosis by targeting Nrf2. Eur Rev Med Pharmacol Sci2017;
21:5456–61
35.
HuangHCNguyenTPickettCB.Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription. J Biol Chem2002;
277:42769–74
36.
NitureSKJainAKJaiswalAK.Antioxidant-induced modification of INrf2 cysteine 151 and PKC-delta-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance. J Cell Sci2009;
122:4452–64
37.
ZhangHFormanHJ.Acrolein induces heme oxygenase-1 through PKC-delta and PI3K in human bronchial epithelial cells. Am J Respir Cell Mol Biol2008;
38:483–90
