The growth arrest and DNA damage 45 (GADD45) family genes regulate DNA repair,
cell cycle, cell survival, apoptosis, senescence, and DNA demethylation in the
cells under various stress stimuli, such as oxidative stress, UV radiation, and
oncogenic stress. Recent studies have provided important insights regarding how
different oncogenic stresses activate GADD45 signaling pathway and lead to
disparate influences on tumor initiation. In this review, we discuss the
deregulation and cellular function of GADD45 proteins in the context of cancer
development. We also highlight recent advances in exploring the tumor
suppressive function of GADD45 proteins-triggered cellular senescence.
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