Enzymes and Cancer: A Look Toward the Past as We Move Forward

Klaschka F. Oral Enzymes: New Approach to Cancer Treatment. Gräfelfing , Germany: Forum Medizin; 1996.

Leipner J. , Saller R. Systemic enzyme therapy in oncology. Drugs. 2000;59:769-780.

Popiela T. , Kulig J. , Hanisch J. , Bock PR Influence of a complementary treatment with oral enzymes on patients with colorectal cancers-an epidemiological retrolective cohort study. Cancer Chemother Pharmacol. 2001;47(suppl):S55-S63.

Sakalová A. , Bock PR , Dedík L. , et al. Retrolective cohort study of an additive therapy with an oral enzyme preparation in patients with multiple myeloma. Cancer Chemother Pharmacol. 2001;47(suppl):S38-S44.

Anonymous. Chemotherapy with or without Wobe-Mugos E in treating patients with stage II or stage III multiple myeloma. http://www.clinicaltrials.gov/ct2/show/NCT00014339?/term=wobe&rank=1. Accessed September 17, 2008.

Kaul R. , Mishra BK , Sutradar P. , Choudhary V. , Gujral MS The role of Wobe-Mugos in reducing acute sequelae of radiation in head and neck cancers-a clinical phase-III randomized trial. Indian J Cancer. 1999;36:141-148.

Gujral MS , Patnaik PM , Kaul R. , et al. Efficacy of hydrolytic enzymes in preventing radiation therapy-induced side effects in patients with head and neck cancers. Cancer Chemother Pharmacol. 2001;47(suppl):S23-S28.

Dale PS , Tamhankar CP , George D. , Daftary GV Co-medication with hydrolytic enzymes in radiation therapy of uterine cervix: evidence of the reduction of acute side effects. Cancer Chemother Pharmacol. 2001;47(suppl):S29-S34.

Martin T. , Uhder K. , Kurek R. , et al. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial. Radiother Oncol. 2002;65:17-22.

Dörr W. , Herrmann T. ; Study Group. Efficacy of Wobe-Mugos E for reduction of oral mucositis after radiotherapy: results of a prospective, randomized, placebo-controlled, triple-blind phase III multicenter study. Strahlenther Onkol. 2007;183: 121-127.

Desser L. , Holomanova D. , Zavadova E. , Pavelka K. , Mohr T. , Herbacek I. Oral therapy with proteolytic enzymes decreases excessive TGF-beta levels in human blood. Cancer Chemother Pharmacol. 2001;47(suppl):S10-S15.

Jones S. , Zhang X. , Parsons DW , et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science. 2008;321:1801-1806.

McCarty MF , Block KI Multifocal angiostatic therapy: an update. Integr Cancer Ther . 2005;4:301-314.