Clinical Observation of Diabetic Foot Treated by Mixed Probiotics Formulation Combined with Standard Care

Abstract

The aim of this study was to evaluate the efficacy and safety of a mixed probiotics formulation (MPF) combined with standard care for treating diabetic foot (DF), specifically targeting infection control, ulcer healing, and wound recovery. Seventy DF patients were randomly assigned to receive standard therapy alone or in combination with MPF. Following the treatment, ankle-brachial index (ABI), wound characteristics, inflammatory markers, ultrasound measurements, vascular endothelial markers, blood glucose levels, and recurrence rates were evaluated at 8-week and 12-week timepoints. Significant improvements were observed in the MPF-treated group after 12 weeks compared to the control group, including reductions in body mass index (BMI) and waist circumference (p < 0.05), as well as improvements in wound healing outcomes, ABI scores (p < 0.05), ultrasound parameters, and vascular endothelial markers (p < 0.05). While blood glucose levels decreased similarly in both groups (p > 0.05), the MPF group exhibited a lower recurrence rate (11.43%) compared to the control group (25.71%). Importantly, MPF was well-tolerated with no adverse events reported. In conclusion, MPF, when used alongside standard care, significantly improves BMI, waist circumference, ABI scores, wound healing, and vascular parameters in DF patients. These findings indicated the potential of MPF for clinical application in the management and prevention of diabetic foot complications.