Diabetic foot ulcer is a severe Diabetic Mellitus-associated complication. It is induced by poor glycemic control, which leads to peripheral neuropathy and vascular diseases. Platelet-rich plasma could be beneficial for healing processes due to its active biomolecules that promotes immunomodulation, angiogenesis, cell proliferation and analgesia.
SlesaczeckTPaetzoldHNanningT, et al.Autologous derived, platelet-rich plasma gel in the treatment of nonhealing diabetic foot ulcer: a case report. Ther Adv Endocrinol Metab. 2012;3(2):75‐78.
2.
LimJZNgNSThomasC. Prevention and treatment of diabetic foot ulcers. J R Soc Med. 2017;110(3):104‐109.
International Diabetes Federation. IDF Diabetes Atlas. 9th edn. Brussels: 2019. Accessed July 22, 2021. Available at: https://www.diabetesatlas.org
5.
MohammadiMHMolaviBMohammadiS, et al.Evaluation of wound healing in diabetic foot ulcer using platelet-rich plasma gel: a single-arm clinical trial. Transfus Apher Sci. 2017;56(2):160‐164.
6.
GraietHLokchineAFrancoisP, et al.Use of platelet-rich plasma in regenerative medicine: technical tools for correct quality control. BMJ Open Sport & Exercise Medicine. 2018;4(1):e000442. Published 2018 Nov 13.
7.
Ramaswamy ReddySHReddyRBabuNCAshokGN. Stem-cell therapy and platelet-rich plasma in regenerative medicines: a review on pros and cons of the technologies. J Oral Maxillofac Pathol. 2018;22(3):367‐374.
8.
ChoJWKimSALeeKS. Platelet-rich plasma induces increased expression of G1 cell cycle regulators, type I collagen, and matrix metalloproteinase-1 in human skin fibroblasts. Int J Mol Med. 2012;29(1):32‐36.
9.
EtulainJ. Platelets in wound healing and regenerative medicine. Platelets. 2018;29(6):556‐568.
10.
EvertsPOnishiKJayaramPLanaJFMautnerK. Platelet-rich plasma: new performance understandings and therapeutic considerations in 2020. Int J Mol Sci. 2020;21(20):7794. Published 2020 Oct 21.
11.
KufflerDP. Platelet-Rich plasma promotes axon regeneration, wound healing, and pain reduction: fact or fiction. Mol Neurobiol. 2015;52(2):990‐1014.
12.
Chicharro-AlcántaraDRubio-ZaragozaMDamiá-GiménezE, et al.Platelet rich plasma: new insights for cutaneous wound healing management. J Funct Biomater. 2018;9(1):10. Published 2018 Jan 18.
13.
RodriguesMKosaricNBonhamCAGurtnerGC. Wound healing: a cellular perspective. Physiol Rev. 2019;99(1):665‐706.
14.
HongWXHuMSEsquivelM, et al.The role of hypoxia-inducible factor in wound healing. Adv Wound Care (New Rochelle. 2014;3(5):390‐399.
15.
BrownleeM. The pathobiology of diabetic complications: a unifying mechanism. Diabetes. 2005;54(6):1615‐1625.
16.
RosenbergerDCBlechschmidtVTimmermanHWolffATreedeRD. Challenges of neuropathic pain: focus on diabetic neuropathy. J Neural Transm (Vienna). 2020;127(4):589‐624.
17.
TsudaM. Microglia-Mediated regulation of neuropathic pain: molecular and cellular mechanisms. Biol Pharm Bull. 2019;42(12):1959‐1968.
18.
BouhlelMADerudasBRigamontiE, et al.PPARgamma activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties. Cell Metab. 2007;6(2):137‐143.
19.
SandireddyRYerraVGAretiAKomirishettyPKumarA. Neuroinflammation and oxidative stress in diabetic neuropathy: futuristic strategies based on these targets. Int J Endocrinol. 2014;2014:1‐10. doi:10.1155/2014/674987.
RahDKMinHJKimYWCheonYW. Effect of platelet-rich plasma on ischemia-reperfusion injury in a skin flap mouse model. Int J Med Sci. 2017;14(9):829‐839. Published 2017 Jul 19.
22.
LeADKEnwezeLDeBaunMRDragooJL. Current clinical recommendations for use of platelet-rich plasma. Curr Rev Musculoskelet Med. 2018;11(4):624‐634.
23.
LanaJFSDPuritaJPaulusC, et al.Contributions for classification of platelet rich plasma - proposal of a new classification: MARSPILL. Regen Med. 2017;12(5):565‐574. Epub 2017 Jul 31.
