Maggot debridement therapy (MDT) has been used for years in the treatment of chronic wounds and necrotic tissues. We report a case of subtotally amputated third toe that was treated with MDT after reattachment and developing complete necrosis. The necrotic toe was replaced with viable tissue and the wound healed completely after 2 weeks of MDT application. This case points out the regenerative effects of MDT besides its mechanical debridement effect on the necrotic tissue.
ShermanRAHallMJRThomasS.Medicinal maggots: an ancient remedy for some contemporary afflictions. Annu Rev Entomol. 2000;45:55-81.
2.
DavydovL.Maggot therapy in wound management in modern era and a review of published literature. J Pharm Pract. 2011;24:89-93.
3.
RaposioEBortoliniSMaistrelloLGrassoDA.Larval therapy for chronic cutaneous ulcers: historical review and future perspectives. Wounds. 2017;29:367-373.
4.
AbelaG.Benefits of maggot debridement therapy on leg ulcers: a literature review. Br J Community Nurs. 2017;22(suppl 6):S14-S19.
5.
PretePE.Growth effects of Phaenicia sericata larval extracts on fibroblasts: mechanism for wound healing by maggot therapy. Life Sci. 1997;60:505-510.
6.
GrassbergerMFleischmannW.The biobag—a new device for the application of medicinal maggots. Dermatology. 2002;204:306.
7.
ShermanRA.Maggot therapy for foot and leg wounds. Int J Low Extrem Wounds. 2002;1:135-142.
8.
CarlsonB.Crawling through the millennia: maggots and leeches come full circle. Biotechnol Healthc. 2006;3:14-17.
9.
DumvilleJCWorthyGBlandJM, et al. Larval therapy for leg ulcers (VenUS II): randomised controlled trial. BMJ. 2009;338:1047-1049.
10.
CourtenayMChurchJCTRyanTJ. Larva therapy in wound management. J R Soc Med. 2000;93:72-74.
11.
SteenvoordePJacobiCEVan DoornLOskamJ.Maggot debridement therapy of infected ulcers: patient and wound factors influencing outcome—a study on 101 patients with 117 wounds. Ann R Coll Surg Engl. 2007;89:596-602.
12.
OpletalováKBlaizotXMourgeonB, et al. Maggot therapy for wound debridement: a randomized multicenter trial. Arch Dermatol. 2012;148:432-438.
13.
CourtneyGWPapeTSkevingtonJHSinclairBJ. Biodiversity of diptera. In: FoottitRGAdlerPH, eds. Insect Biodiversity: Science and Society. Wiley-Blackwell; 2009:185-222.
14.
LiPNLiHZhongLX, et al. Molecular events underlying maggot extract promoted rat in vivo and human in vitro skin wound healing. Wound Repair Regen. 2015;23:65-73.
VistnesLLeeRKsanderG.Proteolytic activity of blowfly larvae secretions in experimental burns. Surgery. 1981;90:835-841.
17.
ShermanRA.A new dressing design for use with maggot therapy. Plast Reconstr Surg. 1997;100:451-456.
18.
TelfordGBrownAPSeabraRAM, et al. Degradation of eschar from venous leg ulcers using a recombinant chymotrypsin fromLucilia sericata. Br J Dermatol. 2010;163:523-531.
19.
KerridgeALappin-ScottHStevensJR.Antibacterial properties of larval secretions of the blowfly, Lucilia sericata. Med Vet Entomol. 2005;19:333-337.
20.
HorobinAJShakesheffKMPritchardDI.Maggots and wound healing: an investigation of the effects of secretions from Lucilia sericata larvae upon the migration of human dermal fibroblasts over a fibronectin-coated surface. Wound Repair Regen. 2005;13:422-433.
21.
TamuraTCazanderGRooijakkersSHMTrouwLANibberingPH.Excretions/secretions from medicinal larvae (Lucilia sericata) inhibit complement activation by two mechanisms. Wound Repair Regen. 2017;25:41-50.
22.
CazanderGSchreursMWJRenwarinLDorresteijnCHamannDJukemaGN.Maggot excretions affect the human complement system. Wound Repair Regen. 2012;20:879-886.
23.
ZhangZWangSTianXZhaoZZhangJLvD.A new effective scaffold to facilitate peripheral nerve regeneration: chitosan tube coated with maggot homogenate product. Med Hypotheses. 2010;74:12-14.
24.
BexfieldABondAEMorganC, et al. Amino acid derivatives from Lucilia sericata excretions/secretions may contribute to the beneficial effects of maggot therapy via increased angiogenesis. Br J Dermatol. 2010;162:554-562.
25.
AlipourHShahriari-NamadiMEbrahimiSMoemenbellah-FardMD.Wound healing potential: evaluation of molecular profiling and amplification of Lucilia sericata angiopoietin-1 mRNA mid-part. BMC Res Notes. 2020;13:308.
26.
NaikGHardingK.Maggot debridement therapy: the current perspectives. Chronic Wound Care Manag Res. 2017;4:121-128.
27.
ShermanRA.Maggot versus conservative debridement therapy for the treatment of pressure ulcers. Wound Repair Regen. 2002;10:208-214.
