Necrobiotic xanthogranuloma is a progressive histiocytic granulomatous disease with frequent extracutaneous involvement. We have documented an unusual case of necrobiotic xanthogranuloma in a 58-year-old man with a history of recalcitrant and chronic arm and leg ulcerations in the absence of characteristic periorbital involvement. Our patient demonstrates a therapeutic challenge and may display a new necrobiotic inflammatory disorder not previously characterized.
SpicknallKEMehreganDA. Necrobiotic xanthogranuloma. Int J Dermatol. 2009;48:1-10.
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McGregorJMMillerJSmithNPHayRJ. Necrobiotic xanthogranuloma without periorbital lesions. J Am Acad Dermatol. 1993;29:466-469.
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SabetLMWexlerDSalamaSGanBS. An unusual cause of refractive chronic bilateral leg ulceration. J Cutan Med Surg. 2004;8:432-437.
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EfeberaYBlanchardEAllamCHanALeeSMunshiN. Complete response to thalidomide and dexamethasone in a patient with necrobiotic xanthogranuloma associated with monoclonal gammopathy: a case report and review of the literature. Clin Lymphoma Myeloma Leuk. 2011;11:298-302.
