Documented cases of malignant transformation of foot ulcer in a diabetic patient in medical literature are very few. This study presents 2 interesting cases of long-standing diabetic foot ulcer, which were subsequently diagnosed to have squamous cell carcinoma on histopathological examination.
Armstrong DG , Lavery LADiabetic foot ulcers: prevention, diagnosis and classification. Am Fam Physician. 1998 ;57:1325-1332, 1337-1338.
2.
Bowering CKDiabetic foot ulcers: pathophysiology, assessment and therapy. Can Fam Physician. 2001;47:1007-1016.
3.
Kong MF, Jogia R., Jackson S., Quinn M., McNally P., Davies M.Malignant melanoma presenting as a foot ulcer (case report). Lancet. 2005;366:1750.
4.
Kong MF, Jogia R., Jackson S., Quinn M., McNally P., Davies M.When to biopsy a foot ulcer? Seven cases of malignant melanoma presenting as foot ulcers. Practical Diabetes Int. 2008 ;25:5-8.
5.
Gregson CLAmelanotic malignant melanoma disguised as a diabetic foot ulcer. Diabet Med. 2004;21:924-927.
6.
Kong MF, Jogia R., Nayyar V., Berrington R., Jackson S.Squamous cell carcinoma in a heel ulcer in a patient with diabetes. Diabetes Care. 2008:31: e57.
7.
Cruickshank AH, Gaskell E.Jean-Nicolas Marjolin: destined to be forgotten . Med Hist. 1963;7:383-384.
8.
Ogawa B., Chen M., Margolis J., Schiller FJ, Schnall SBMarjolin’s ulcer arising at the elbow: a case report and literature review. Hand. 2006;1:89-93.
9.
Snyder RJ, Stillman RM, Weiss SDEpidermoid cancers that masquerade as venous ulcer disease. Ostomy Wound Manage. 2003;49(4):63-66.
10.
Visuthikosol V., Boonpucknavig V., Nitiquanant P.Squamous carcinoma in scars: clinicopathological correlations. Ann Plast Surg. 1986;16:42-48.
11.
Lauvin R., Miglianico L., Hellegouarc’h R. Skin cancer occurring 10 years after the extravasation of doxorubicin. N Engl J Med. 1995;332:754.
12.
Vishniavsky S.Squamous cell carcinoma in sinus tract of chronic osteomyelitis. Va Med Mon. 1970;97:645-650.
13.
Hammond J., Thomsen S., Ward G.Scar carcinoma arising acutely in a skin graft donor site. J Trauma. 1987;27: 681-683.
14.
Christopher JW, Li BD, Gonzalez E., Valiulis JP, Cunningham M., McCulloch J.Nonhealing ulcer in a diabetic foot. Wounds. 2004;16:212-217.
15.
Schöttler L., Körber A., Denisjuk N., Freise J., Dissemond J.Malignant melanoma masquerading as a neurotropic ulcer [in German]. Med Klin (Munich). 2009;104:723-726.
16.
Schnirring-Judge M., Belpedio D.Malignant transformation of a chronic venous stasis ulcer to basal cell carcinoma in a diabetic patient. Case study and review of the pathophysiology. J Foot Ankle Surg. 2010;49:75-79.
17.
Preston-Martin S., Pike MC, Ross RK, Jones PA, Henderson BEIncreased cell division as a cause of human cancer. Cancer Res. 1990;50:7415-7421.
