Restricted accessResearch articleFirst published online 2009-12
Successful Pharmacological Treatment and Treatment of Large Soft-Tissue Ulceration With Split-Thickness Skin Graft in a Chronically Critical Ischemic Leg
The authors present the results of preoperative and postoperative prostacyclin analog treatment with skin grafting in a large ulceration of a chronic critical ischemic leg in a man who had lost his contralateral extremity 5 years ago. Healing was uneventful at the 6-month follow-up.
Dean SM, Vaccaro PSSuccessful pharmacologic treatment of lower extremity ulcerations in 5 patients with chronic critical limb ischemia. J Am Board Fam Pract2002;15:55-62.
2.
Di Stefano R. , Barsotti MC, Melillo E., Iorio M., Santoni T., Armani C., et al. The prostacyclin analogue iloprost increases circulating endothelial progenitor cells in patients with critical limb ischemia. Thromb Haemost2008;100:871-7.
3.
Slovut DP, Sullivan TMCritical limb ischemia: medical and surgical management. Vasc Med2008;13:281-91.
4.
Belcher G.Effects of iloprost and factors affecting outcome in patients with severe inoperable lower limb ischemia: UK severe limb ischemia study group. Agents Actions Suppl1992; 37:354-60.
5.
Kummer O., Widmer MK, Plüss S., Willenberg T., Vögele J., Mahler F., et al. Does infection affect amputation rate in chronic leg ischemia?Vasa2003;32:18-21.
