Evaluation of Wound-Healing Potential of Pisonia grandis R.Br: A Preclinical Study in Wistar Rats

Abstract

Pisonia grandis R.Br (family: Nyctaginaceae) is a herb claimed to be used for treatment of inflammation, wound healing, algesia, and ulcer. The present study was done to evaluate the wound-healing potential of methanolic extract of its leaves. Following preliminary photochemical evaluation, the extract was incorporated in simple ointment base and evaluated using 2 types of wound models in Wistar rats—excision wound and incision wound. The results were significantly different ( p <0.05) when compared with control group for wound contraction, tensile strength, and histopathological and biological parameters. Antibacterial studies against different bacterial strains of the test samples were performed by the disk-diffusion method and were compared with standard ofloxacin and erythromycin. Test sample showed comparable zone of inhibition to the standards. It is hypothesized that the presence of phytoconstituents with the antibacterial effect helps in wound healing.

Keywords

Pisonia grandis wound healing incision excision antibacterial Wistar rat

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