The potential efficacy of fresh turmeric (Curcuma longa) paste to heal wounds was tested in a preclinical study in an animal model. Turmeric paste was comparedwith honey as a topicalmedicament against a control on experimentally created full-thickness circular wounds in 18 rabbits (Oryctolagous cuniculus). Wound healing was assessed on the basis of physical, histomorphological, and histochemical parameters on treatment days 0, 3, 7, and 14. Only tensile strength was measured on day 14 of treatment. It was observed that the wound healing was statistically significantly faster (P < .01) in both treatment groups compared to the control group.
Myers KA, Marshall RD, Freid IN. Infection, prevention and control. Wound healing skin. In: Principles of pathology in surgery. 1st ed.Oxford: Blackwell Scientific Publications; 1980. p. 58-242.
2.
Probst WC, Bright MR. In: Douglas HS. Wound healing: the textbook of small animal surgery. Philadelphia: W. B. Saunders; 1985. p. 28-36.
3.
Araujo CAC, Leon LA. Biological activities of Curcuma longa L. Memorias-do Instituto-Oswaldo-Cruz 2001; 96(5):723-728.
4.
Jayaprakash GK, Negi PS, Anandharama krishnan C, et al. Chemical composition of turmeric oil—a byproduct from turmeric oleoresin industry and its inhibitory activity against different fungi. Z Naturforsch [C] 2001;56(1-2):40-44.
5.
Kapur A, Kapur A. Antifungal activities of fresh juice and aqueous extract of turmeric (Curcuma longa) and Ginger (Zingiber officinale). J Phytological Research1997;10(1-2):59-62.
6.
Gonda R, Tomoda M. Arabinogalactan core structure and immunological activities of Ikonan C, an acidic polysaccharide from rhizome of Curcuma longa. Biol Pharm Bull1993;16(3):235-238.
7.
Armon PJ. The use of honey in the treatment of infected wounds. Trop Doct1980;10:91-91.
8.
Braniki FJ. Surgery in Western Kenya. Ann R Coll Surg Engl1981;63:348-352.
9.
Willix DJ, Molan PC, Harfoot CJ. A comparison of the sensitivity of wound infecting species of bacteria to the antibacterial activity of manuka honey and other honey. Appl Bacterial1992;73:388-394.
10.
Molan PC. The antibacterial activity of honey: the nature of antibacterial activity. Bee World1992;73(1):5-28.
11.
Cooper RA, Molan PC, Harding KG. The effectiveness of the antibacterial activity of honey against strains of Staphylococcus aureus isolated from infected wounds. J Soc Med1999;92:283-285.
12.
Al-Jabri AA, Nzeako B. In vitro antibacterial activity if Omani and African honey. Br J Biomed Sci2003;60(1):1-4.
13.
Abenavoli FM, Corelli R. Honey cream. Ann Plast Surg2003;50(1):105-106.
14.
Miorin PL, Levy J. Antibacterial activity of honey and propolis from Apis mellifera and Tetragonisca angustula against Staphylococcus aureus. J Appl Microbiol2003;95(5):913-920.
15.
Suguna L, Chandrakasan G, Thomas Joseph K. Influence of honey in collagen metabolism during wound healing in rats. J Clin Biochem Nutrition1992;13:7-7.
16.
Betts JA, Molan PC. Apilot trial of honey as awounddressing has shown the importance of the way that honey is applied to wounds. Proceedings of the 11th conference of the European Wound Management Association; 2001; Dublin, Ireland.
17.
Phuapradit W, Sasopala N. Topical application of honey in treatment of abdominal wound disruption. Aust N Z J Obst Gynecol1992;32(4):381-384.
18.
Ahmed KAJ, Hoekstra MJ. Honey medicated dressing: transformation of an ancient remedy into modern therapy. Ann Plast Surg2003;50(2):143-148.
19.
Tripathi KD. In: Antiseptics, disinfectants and ectoparasiticides. In: Essentials of medical pharmacology. 2nd ed.New Delhi: Jaypee Brothers; 1995. p. 785-790.
20.
Biswas TK, Auddy B, Mukherjee B, et al. Wound healing activity of human placental extracts in rats. Acta Pharmacol Sin2001;22(12);1113-1116.
21.
Singh UB, Sulochana S. Special stain. In: Handbook of histological and histochemical techniques. 2nd ed.Hydarabad (India): Premier; 1996-1997. p. 42-43.
22.
Mallory FB. Pathological techniques. New York: Hafner; 1961. p. 154-155.
23.
Gridley MF. Amodification of the silver impregnationmethod of staining reticular fibers. Amer J Clin Path1951;21:897-899.
24.
Kumar A. Experimental evaluation of honey and an indigenous agent Canisep for their wound healing potential in goats [MVSc thesis]. Ranchi, Jharkhand, India: Birsha Agricultural University, 2002.
25.
Sen C, Khanna S, Gordillo G, et al. Oxygen, oxidants and anti-oxidants in wound healing: an emerging paradigm. Ann N Y Acad Sci2002;957:239-249.
26.
Vardi A, Barzilay Z, Linder N, et al. Local application of honey for the treatment of neonatal postoperative wound infection. Acta Paediatrica1998;87(4):429-432.
