Advances in wound healing have been slow—from the realization of a concept through to its adoption into clinical practice. There are well-known and understood reasons for this conservative approach. One less well-tried thought is to stratify the patient’s physiological status with regard to the wound. This may be the key to quantify changes in wound milieu and therefore to progress.
Bird CE, McKay EM.Healing of wounds. Experimental study to show influence of body dehydration. Surg Gynecol Obstet1932;54:872.
2.
Faunholt A.An account of the ravages of scurvy in Lord Anson’s fleet during a voyage around the world, 1740-44, and some notes concerning British naval hygiene at the time. Mil Surgeon1909;25:38.
Crandon JH, Lund CC.Vitamin C deficiency in an otherwise normal adult. N Engl J Med1940;222:748.
5.
Du Nouy PL.Cicatrization of wounds II. Mathematical expression of the curve representing cicatrization. J Exp Med1916;24:451.
6.
Du Nouy PL.Cicatrization of wounds III. The relation between the age of the patient, the area of the wound, and the index of cicatrization. J Exp Med1916;24:461.
7.
Schulze S, Andersen J, Overgaard H, et al.Effect of prednisolone on the systemic response and wound healing after colonic surgery. Arch Surg1997;132(2):129-135.
8.
Jorgensen LN, Kallehave F, Christensen E, Siana JE, Gottrup F.Less collagen production in smokers. Surgery1998;123(4):450-455.
9.
Hunt TK, Hopf HW.Wound healing and wound infection. What surgeons and anesthesiologists can do. Surg Clin N Am1997;77:587-606.
10.
Kurtz A.Mild perioperative hypothermia. N Engl J Med1997; 336:1730-1737.
11.
Jorgensen LN, Kallehave F, Karlsmark T, Gottrup F.Reduced collagen accumulation after major surgery. Br J Surg1996;83(11):1591-1594.
12.
Jorgensen LN, Sorensen LT, Kallehave F, Schulze S, Gottrup F.Increased collagen deposition in an uncomplicated surgical wound compared to a minimal subcutaneous test wound. Wound Rep Regen2001;9(3):194-199.
13.
Pajulo OT, Pulkki KJ, Viljanto JA, et al.Hyaluronic acid in incision wound fluid: a clinical study with the Cellstick® device in children. Wound Rep Reg2001;9:200-204.
