Reliable assessment of change from previous cognitive functioning is a prerequisite for determining the possible presence of neurodegenerative diseases such as Alzheimer's disease (AD). We investigated whether standardized change scores on the German version of the Consortium to Establish a Registry for Alzheimer's Disease-Neuropsychological Assessment Battery (CERAD-NAB) could be used for early diagnosis of AD and whether change scores on the CERAD-NAB are superior in this respect to scores recorded on 1 occasion only. Three hundred seventy-four normal control subjects were assessed twice. Data from 95 patients with mostly mild probable AD were collected at their first entry to a memory clinic and an average of 1.1 ± 0.24 years later. It is concluded that repeated testing with the CERAD-NAB does not generally add to improved diagnostic accuracy for mild and very mild AD and cannot, therefore, be recommended as a routine clinical procedure.
Ott A., Breteler MM, van Harskamp F., et al. Prevalence oF Alzheimer's disease and vascular dementia: association with education: the Rotterdam study. BMJ.1995; 310:970-973.
2.
Katzman R., Kawas C.The epidemiology oF dementia and Alzheimer disease. In Terry RD, Katzman R, Bick KL, eds. Alzheimer Disease. New York, NY: Raven Press; 1994:105-122.
3.
Bäckman L., Jones S., Berger A-K., Laukka EJ, Small BJMultiple cognitive deFicits during transition to Alzheimer's disease. J Intern Med.2004:256:195-204.
4.
Small BJ, Mobly JL, Jonsson Laukka E., Jones S., Bäckman L.Cognitive deFicits in preclinical Alzheimer's disease. Acta Neurol Scand.2003;107:29-33.
5.
Howieson DB, Dame A., Camicioli R., Sexton G., Payami H., Kaye JACognitive markers preceding Alzheimer's dementia in the healthy oldest old . J Am Geriatr Soc.1997;45:584-589.
6.
Chen P., RatcliFF G., Belle SH, et al. Patterns oF decline in pre-symptomatic Alzheimer's Disease: a prospective community study. Arch Genet Psychiatry.2001;58:853-858.
7.
Collie A., MaruFF P, ShaFiq-Antonacci R, et al. Memory decline in healthy older people . Neurology. 2001;56: 1533-1538.
8.
Winblad B., Palmer K., Kivipelto M., et al. Mild cognitive impairment: beyond controversies, towards a consensus: report oF the International Working Group on Mild Cognitive Impairment. J Intern Med.2004;256:240-246.
9.
Lezak MD, Howieson D-B., Loring D-W., Hannay H-J., Fischer J-S.Neuropsychological Assessment. 4th ed. New York, NY: OxFord University Press; 2004:Xiv, 1016.
10.
Longstreth LE, Alcorn MBSusceptibility oF Wechsler Spatial Ability to experience with related games. Educ Psychol Meas. 1990;50:1-6.
Rabbitt P., Diggle P., Smith D., Holland F., McInnes L.IdentiFying and separating the eFFects oF practice and oF cognitive ageing during a large longitudinal study oF elderly community residents. Neuropsychologia.2001;39: 532-543.
13.
Frank R., Wiederholt WC, Kritz-Silverstein D., Salmon DP, Barrett-Connor E.EFFects oF sequential neuropsychological testing oF an elderly community-based sample. Neuroepidemiology. 1996;15:257-268.
14.
Lowe C., Rabbitt P.Test/re-test reliability oF the CANTAB and ISPOCD neuropsychological batteries: theoretical and practical issues. Neuropsychologia. 1998;36:915-923.
15.
Mitrushina M., Satz P.EFFect oF repeated administration oF a neuropsychological battery in the elderly. J Clin Psychol.1991 ;47:790-801.
16.
Basso MR, Bornstein RA, Lang JMPractice eFFects on commonly used measures oF executive Function across twelve months. Clin Neuropsychol.1999;13:283-292.
17.
Anastasi A.Coaching, test sophistication, and developed abilities. Am Psychol.1981;36:1086-1093.
18.
Temkin NR, Heaton RK, Grant I., Dikmen SSDetecting signiFicant change in neuropsychological test perFormance: a comparison oF Four models. J Int Neuropsychol Soc. 1999 ;5:357-369.
19.
Monsch AU, Thalmann B., Schneitter M., et al. The Basel study on the elderly's search For preclinical cognitive markers oF Alzheimer's disease. Neurobiol Aging. 2000;21:31.
20.
Widmer LK, Stähelin HB, Nissen C., da Silva A.Venen-, Arterien-Krankheiten, koronare Herzkrankheit bei Berufstätigen: Prospektiv-epidemiologische Untersuchung. Basler StudieI-III1959-1978. Bern, Switzerland: Hans Huber; 1981.
21.
Thalmann B., Monsch AU, Schneitter M., et al. The CERAD neuropsychological assessment battery (CERAD-NAB): a minimal dataset as a common tool For German-speaking Europe. Neurobiol Aging. 2000;21:30.
22.
Thalmann B., Spiegel R., Stähelin HB, et al. Dementia screening in general practice: simpliFied scoring For the Clock Drawing Test. BrainAging. 2002;2:36-43.
23.
Kühner C.Fragebogen zur Depressionsdiagnostik Nach DSM-IV (FDD-DSM-IV). Göttingen, Germany: HogreFe; 1997 .
24.
American Psychiatric Association.Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington DC: American Psychiatric Association; 1994.
25.
McKhann G., Drachman D., Folstein M., Katzman R., Price D., Stadlan EMClinical diagnosis oF Alzheimer's disease: report oF the NINCDS-ADRDA work group under the auspices oF department oF health and human services task Force on Alzheimer's disease. Neurology. 1984;34:939-944.
26.
Monsch AU, Foldi NS, Ermini-FünFschilling DE, et al. Improving the diagnostic accuracy oF the Mini-Mental State Examination . Acta Neurol Scand.1995;92:145-150.
27.
Sheikh JI, Yesavage JAGeriatric Depression Scale (GDS): Recent Evidence and Development of a Shorter Version: Clinical Gerontology: A Guide to Assessment and Intervention, NY : The Haworth Press; 1986:165-173.
28.
Ermini-FünFschilling D., Meier D.Gedächtnistraining: Wichtiger Bestandteil der Milieutherapie bei seniler Demenz. Zeitschrift Gerontol Geriatrie.1995;28:190-194.
29.
Folstein MF , Folstein SE, McHugh PR “Mini-Mental State”: a practical method For grading the cognitive state oF patients For the clinician. J Psychiatr Res.1975;12: 189-198.
30.
Morris JC, Heyman A., Mohs RC, et al. The Consortium to Establish a Registry For Alzheimer's Disease (CERAD): I: clinical and neuropsychological assessment oF Alzheimer's disease . Neurology. 1989;39:1159-1165.
31.
Welsh KA, Butters N., Hughes J, Mohs R, Heyman A. Detection oF abnormal memory decline in mild cases oF Alzheimer's disease using CERAD neuropsychological measures . Arch Neurol.1991;48:278-281.
32.
Welsh KA, Butters N., Hughes J, Mohs RC, Heyman A. Detection and staging oF dementia in Alzheimer's disease. Arch Neurol.1992;49:448-452.
33.
Aebi C.Validierung der neuropsychologischen Testbatterie CERAD-NP: Eine Multi-Center Studie [PhD thesis]. Basel, Switzerland: University oF Basel; 2002.
34.
Berres M., Monsch AU, Bernasconi F., Thalmann B., Stähelin HBNormal ranges oF neuropsychological tests For the diagnosis oF Alzheimer's disease. Stud Health Technol Inform.2000;77:195-199.
35.
Hosmer DW, Lemeshow S.Binary Logistic Regression. 2nd ed. New York, NY: Wiley; 2000.
36.
Armitage P., Berry G.Statistical Methods in Medical Research. 3rd ed. Boston, Mass: Blackwell ScientiFic; 1994.
