In an effort to decrease operative morbidity, energy based ablative procedures have triggered considerable interest in the treatment of select, small (<3 cm) renal tumors. Renal cryoablation for small renal tumors is a well-studied energy based ablative procedure that shows considerable promise as an alternative to partial nephrectomy. Cryoablation is minimally invasive and has demonstrated acceptable intermediate-term results. In this article we review key laboratory research and current clinical series of renal cryoablation.
LucianiL. G.CestariR.TallarigoC.Incidental Renal Cell Carcinoma-age and Stage Characterization and Clinical Implications: Study of 1092 Patients (1982–1997). Urology56, 58–62 (2000).
2.
FerganyA. F.HafezK. S.NovickA. C.Long-term Results of Nephron-sparing Surgery for Localized Renal Cell Carcinoma: 10-year Follow-up. J. Urol.163, 442–445 (2000).
BischofJ. C.SmithD.PazhayannurP. V.ManivelC.HulbertJ.RobertsK. P.Cryosurgery of Dunning AT-1 Rat Prostate Tumor: Thermal, Biophysical, and Viability Response at the Cellular and Tissue Level. Cryobiology34, 42–69 (1997).
5.
NinomiyaT.YosimuraH.MoriM.Identification of Vascular System in Experimental Carcinoma for Cryosurgery-Histochemical Observations of Lectin UEA-1 and Alkaline Phosphatase Activity in Vascular Endothelium. Cryobiology22, 331–335 (1985).
6.
AblinR. J.FontanaG.HelpapB.Cryoimmunotherapy: A Conference Report. Eur. Surg. Res.14, 309–316 (1982).
7.
SindelarW. F.JavadpourN.BagleyD. H.Histological and Ultrastructural Changes in Rat Kidney after Cryosurgery. J. Surg. Oncol.18, 363–379 (1981).
8.
OnikG. M.ReyesG.CohenJ. K.PorterfieldB.Ultrasound Characteristics of Renal Cryosurgery. Urology42, 212–215 (1993).
9.
CozziP. J.LynchW. J.CollinsS.VonthethoffL.MorrisD. L.Renal Cryotherapy in a Sheep Model; A Feasibility Study. J. Urol.157, 710–712 (1997).
10.
NakadaS. Y.LeeF. T.Jr.WarnerT. F.ChosyS. G.MoonT. D.Laparoscopic Renal Cryotherapy in Swine: Comparison of Puncture Cryotherapy Preceded by Arterial Embolization and Contact Cryotherapy. J. Endourol.12, 567–573 (1998).
11.
NeelH. B.3rdKetchamA. S.HammondW. G.Requisites for Successful Cryogenic Surgery of Cancer. Arch Surg102, 45–48 (1971).
12.
ChosyS. G.NakadaS. Y.LeeF. T.Jr.WarnerT. F.Monitoring Renal Cryosurgery: Predictors of Tissue Necrosis in Swine. J. Urol.159, 1370–1374 (1998).
SungG. T.GillI. S.HsuT. H.MeraneyA. M.SkacelM.BrainardJ. A.RemerE. M.Effect of Intentional Cryo-injury to the Renal Collecting System. J. Urol.170, 619–622 (2003).
17.
DerweeshI. H.NovickA. C.Small Renal Tumors: Natural History, Observation Strategies and Emerging Modalities of Energy Based Tumor Ablation. Can. J. Urol.10, 1871–1879 (2003).
GillI. S.RemerE. M.HasanW. A.StrzempkowskiB.SteinbergA. P.KaoukJ. H.NovickA. C.DesaiM. M.Renal Cryoablation: Outcome at 3 Years. Submitted.
26.
CarvalhalE. F.GillI. S.AnoopM.Laparoscopic Renal Cryoablation: Impact on Renal Function and Blood Pressure. Urology58, 357–361 (2001).
27.
BishoffJ. T.ChenR. B.LeeB.Laparoscopic Renal Cryoablation: Acute and Long-term Clinical, Radiographic an Pathologic Effects in an Animal Model and Application in a Clinical Trial. J. Endourol.13, 233–239 (1999).
28.
RodriguezR.ChanD. Y.BishoffJ. T.Renal Ablative Cryosurgery in Selected Patients with Peripheral Renal Masses. Urology55, 25–30 (2000).
29.
LeeD. I.McGinnisD. E.FeldR.StrupS. E.Retroperitoneal Laparoscopic Cryoablation of Small Renal Tumors: Intermediate Results. Urology61, 83–88 (2003).
30.
ColonI.FuchsG. J.Early Experience with Laparoscopic Cryoablation in Patients with Small Renal Tumors and Severe Comorbidities. J. Endourol.17, 415–423 (2003).
