A simple standardization of esophageal photodynamic therapy light dosimetry is proposed. Calculations of the effect on local treatment dose of using non-centered diffusing fibers have been made and the methods of calculating light energy dose to the treatment area within a centering balloon are discussed. A requirement for centering devices and standard units of Joules per cm2 of treatment area are indicated.
BarrH., KendallC., StoneN., Photodynamic Therapy for Esophageal Cancer: A Useful and Realistic Option. Technol. Cancer Res. Treat.2, 65–75 (2003).
2.
AckroydR., KeltyC., BrownmN., ReedM.The History of Photodetection and Photodynamic Therapy. Photochem. Photobiol.74, 656–669 (2000).
3.
Clinical Guidelines for Performing Photodynamic Therapy (PDT) on Patients with Bronchopulmonary or Esophageal Cancer. The UK Clinical PDT Study Group. Eurocommunica Publications (2002).
4.
RipleyP. M., MacRobertA. J., MillsT. N., BownS. G.A Comparative Optical Analysis of Cylindrical Diffuser Fibers for Laser Therapy Using Fluorescence Imaging. Lasers Med. Sci.14, 257–268 (1999).
5.
MurrerL. H. P., MarijnissenJ. P. A., StarW. M.Light Distribution by Linear Diffusing Sources for Photodynamic Therapy. Phys. Med. Biol.41, 951–961 (1996).
6.
MurrerL. H. P., MarijnissenJ. P. A., StarW. M.Improvements in the Design of Linear Diffusers for Photodynamic Therapy. Phys. Med. Biol.42, 1461–1464 (1997).
7.
GossnerEndoscopy31, 370–376 (1999).
8.
OverholtB. F., PanjehpourM., HaydekJ. M.Photodynamic Therapy for Barrett's Esophagus: Follow-up in 100 Patients. Gastrointestinal Endoscopy49, 1–7 (1999).
9.
PanjehpourM., OverholtB. F., PhanM. N., HaydekJ. M., RobinsonA. R.Photodynamic Therapy for Barrett's Esophagus using a 20 mm Diameter Light Delivery Balloon. SPIE 4612 (2002).
10.
PanjehpourM., OverholtB. F., DeNovoR. C., SneedR. E., PetersenM. G.Centering Balloon to Improve Esophageal Photodynamic Therapy. Lasers Surg. Med.12, 631–638 (1992).
11.
Van den BerghH.On the Evolution of Some Endoscopic Light Delivery Systems for Photodynamic Therapy. Endoscopy30, 392–407 (1998).
12.
OverholtB. F., LighdaleC. J., WangK., CantoC., BurdickS., BarrH., MarconN., HaggittR. C., BronnerM., TaylorS. L., DepotM.International Multicewntre, Partially Blinded, Randomised Sudy of the Efficacy of Photodynamic Therapy (PDT) Using Porfimer Sodium (POR) for the Ablation of High-Grade Dysplasia (HGD) in Barrett's Esophagus (BE): Results of 24-Month Follow-Up. Gastroenterology124, Suppl 1, A20, 151 (2003).
13.
StarW. M.Light Dosimetry In Vivo. Phys. Med. Biol.42, 763–787 (1997).
14.
MurrerL. H. P., HebedaK. M., MarijnissenJ. P. A., StarW. M.Short-and Long-term Normal Tissue Damage with Photodynamic Therapy in Pig Trachea: A Fluence-response Pilot Study Comparing Photofrin and mTHPC. British Journal of Cancer80, 744–755 (1999).
15.
VulcanT. G., ZhuT. C., RodrigezC. E.Comparison Between Isotropic and Nonisotropic Dosimetry Systems During Intraperitoneal Photodynamic Therapy. Lasers in Surgery and Medicine26, 292–301 (2000).
16.
MurrerL. H. P., MarijnissenJ. P. A., BaasP., Van ZandwijkN., StarW. M.Applicator for Light Delivery and In Situ Light Dosimetry During Endobroncial Photodynamic Therapy: First Measurements in Humans. Lasers Med. Sci.12, 253–259 (1997).
