This special issue of Technology in Cancer Research and Treatment focuses on the versatility of electroporation. Contributed papers report on the basic mechanisms as well as the use of this procedure ex vivo and in vivo. In addition, recent studies utilizing in vivo electroporation for plasmid DNA and drug delivery are presented.
References
1.
NeumannE., Schafer-RidderM., WangY. and HofschneiderP. H.Gene transfer into mouse lyoma cells by electroporation in high electric fields. EMBO J.1, 841–845 (1982).
2.
CosterH. G. L.A quantitative analysis of the voltage-current relationships of fixed charge membranes and the associated property of “punch-through”. Biophys. J.5, 669–686 (1965).
3.
SaleA. J. H. and HamiltonW. A.Effects of high electric fields on microorganisms I. killing of bacteria and yeasts. Biochem. Biophys. Acta148, 781–788 (1967).
4.
PohlH. A. and CraneJ. S.Dielectrophoresis of cells. Biophys. J.11, 711–727 (1971).
5.
CrowleyJ. M.Electrical breakdown of bimolecular lipid membranes as an electromechanical instability. Biophys. J.13, 711–724 (1973).
6.
ZimmermannU., PilwatG., and FriemannF.Dielectric breakdown of cell membranes. Biophys. J.14, 881–899 (1974).
7.
OkinoM., MarumotoM., KanesadaH., KugaK. and MohriH.Electrical impulse chemotherapy for rat solid tumors. Proc. Jpn. Cancer Congress, 46, 420 (1987).
8.
MirL. M., BelehradekM., DomengeC., OrlowskiS., PoddevinJ.Jr., SchwabG., LuboinnskiB. and PaolettiC.Electrochemotherapy, a novel antitumor treatment: First clinical trial. C. R. Acad. Sci. Paris313, 613–618 (1991).
9.
SersaG.Electrochemotherapy: Animal model work review. In: Electrochemotherapy, electrogenetherapy and transdermal drug delivery, pp. 119–136. Eds., JaroszeskiM. J., HellerR., GilbertR., Humana Press, Totowa, NJ (2000).
10.
HellerR., GilbertR. and JaroszeskiM. J.Clinical trials for solid tumors using electrochemotherapy. In: Electrochemotherapy, electrogenetherapy and transdermal drug delivery, pp. 137–156. Eds., JaroszeskiM. J., HellerR., GilbertR., Humana Press, Totowa, NJ (2000).
11.
TitomirovA. V., SukharevS. and KistanovaE.In vivo electroporation and stable transformation of skin cells of newborn mice by plasmid DNA. Biochim. Biophys. Acta1088, 131–134 (1991).
12.
HellerR., JaroszeskiM., AtkinA., MoradpourD., GilbertR., WandsJ., and NicolauC.In Vivo Gene Electroinjection and Expression in Rat Liver Fed. Europ. Biochem. Soc. (FEBS) Letters389, 225–228 (1996).
13.
NishiT., YoshizatoK., YamashiroS., TakeshimaH., SatoK., HamadaK., KitamuraI., YoshimuraT., SayaH., KuratsuJ. and UshioY.High-efficiency in vivo gene transfer using intraarterial plasmid DNA injection following in vivo electroporation. Cancer Res.56, 1050–1055 (1996).
14.
LucasM. L., HellerL., CoppolaD. and HellerR.IL-12 Electrogene-therapy for the successful treatment of established subcutaneous B16F10 melanoma. Mol. Therapy5, 668–675 (2002).
15.
LiS., ZhangX. and XiaX.Regression of tumor growth and induction of long-term antitumor memory by interleukin 12 electro-gene therapy. J. Natl. Cancer Inst.94, 762–768 (2002).