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Abstract

The study was conducted to determine if ci'ostazol inhibits leukocyte MVac-i, leading to prevention of poststent restenosis. C lostazol inhibits platelet phosphodiesterase III as well as u-granule release of P-selection in platelets, which have a key role in the upregulation of leucocyte Mac1. The activation and upregulation of NMac-i .s key in the mechanism of restenosis after coronary stenting. Consecutive patients (n = 70) undergoing coronary stenting were randomly assigned to either cilostazol or ticlopidine before stent placement. The 34 patients in the cilostazol group had a lower rate of restenosis than tne 22 patients in the ticlopidire group. Cilostazol suppressed stent-induced increases .n platelet. P selection expression and an increase in neutrophil Mac-I expression. The authors concluded that cilostazol may reduce the rate of restenosis after coronary stent implantation.

Keywords

stent restenosis cilostazol platelets

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Cilostazol Inhibits Leukocyte Integrin Mac-1,Leading to a Potential Reduction in Restenosis After Coronary Stent Implantation

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