The development of diabetes after solid organ transplantation is a known complication, and many published studies have examined prevalence rates and risk factors for specific categories of transplant recipients. However, fewer articles have compared rates of posttransplant diabetes and risk factors among different types of transplant recipients. This article provides an overview of the literature on this subject and compares similarities and differences related to posttransplant diabetes for different categories of organ transplant recipients. Awareness of the various risk factors for different organ transplant recipients will enhance transplant clinicians' knowledge related to this complication so that appropriate monitoring can be started.
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References
1.
WilkinsonADavidsonJDottaF. Guidelines for the treatment and management of new-onset diabetes after transplantation. Clin Transplant.2005;19(3):291–298.
2.
DavidsonJWilkinsonADantalJ. New-onset diabetes after transplantation: 2003 international consensus guidelines. Transplantation.2003;75(10 suppl):SS3–SS24.
3.
KnoblerHStagnaro-GreenAWallensteinSSchwartzMRomanSH. Higher incidence of diabetes in liver transplant recipients with hepatitis C. J Clin Gastroenterol.1998;26(1):30–33.
4.
AldosaryAARamjiASElliottTG. Post-liver transplantation diabetes mellitus: An association with hepatitis C. Liver Transpl.2002;8(4):356–361.
5.
HjelmesaethJHartmannALeivestadT. The impact of early-diagnosed new-onset post-transplantation diabetes mellitus on survival and major cardiac events. Kidney Int.2006;69(3):588–595.
JohnPRThuluvathPJ. Outcome of patients with new-onset diabetes mellitus after liver transplantation compared with those without diabetes mellitus. Liver Transpl.2002;8(8):708–713.
8.
TrailKCMcCashlandTMLarsenJL. Morbidity in patients with posttransplant diabetes mellitus following orthotopic liver transplantation. Liver Transpl Surg.1996;2(4):276–283.
9.
DriscollCCashionAHathawayDK. Posttransplant diabetes mellitus in liver transplant recipients. Prog Transplant.2006;16(2):110–116.
10.
Report of the expert committee on the diagnosis and classification of diabetes mellitus.Diabetes Care.2003;26(suppl 1):S5–S20.
11.
MarkellM. New-onset diabetes mellitus in transplant patients: Pathogenesis, complications, and management. Am J Kidney Dis.2004;43(6):953–965.
12.
KrentzAJWheelerDC. New-onset diabetes after transplantation: A threat to graft and patient survival. Lancet.2005;365(9460):640–642.
13.
SouleJLOlyaeiAJBoslaughTA. Hepatitis C infection increases the risk of new-onset diabetes after transplantation in liver allograft recipients. Am J Surg.2005;189(5):552–557.
14.
CosioFGPesaventoTEOseiKHenryMLFergusonRM. Post-transplant diabetes mellitus: Increasing incidence in renal allograft recipients transplanted in recent years. Kidney Int.2001;59(2):732–737.
15.
HertzMITaylorDOTrulockEP. The registry of the International Society for Heart and Lung Transplantation: Nineteenth official report, 2002. J Heart Lung Transplant.2002;21(9):950–970.
16.
KasiskeBLSnyderJJGilbertsonDMatasAJ. Diabetes mellitus after kidney transplantation in the United States. Am J Transplant.2003;3(2):178–185.
17.
van HooffJPChristiaansMHvan DuijnhovenEM. Evaluating mechanisms of post-transplant diabetes mellitus. Nephrol Dial Transplant.2004;19(suppl 6):vi8–vi12.
18.
MontoriVMBasuAErwinPJVelosaJAGabrielSEKudvaYC. Posttransplantation diabetes: A systematic review of the literature. Diabetes Care.2002;25(3):583–592.
19.
Martinez-DolzLAlmenarLMartinez-OrtizL. Predictive factors for development of diabetes mellitus post-heart transplant. Transplant Proc.2005;37(9):4064–4066.
20.
TuecheSG. Diabetes mellitus after liver transplant new etiologic clues and cornerstones for understanding. Transplant Proc.2003;35(4):1466–1468.
21.
WalczakDACalvertDJarzembowskiTM. Increased risk of post-transplant diabetes mellitus despite early steroid discontinuation in Hispanic kidney transplant recipients. Clin Transplant.2005;19(4):527–531.
22.
KhaliliMLimJWBassNAscherNLRobertsJPTerraultNA. New onset diabetes mellitus after liver transplantation: The critical role of hepatitis C infection. Liver Transpl.2004;10(3):349–355.
23.
SalibaFLakehalMPageauxGP. Risk factors for new-onset diabetes mellitus following liver transplantation and impact of hepatitis C infection: An observational multicenter study. Liver Transpl.2007;13(1):136–144.
24.
DepczynskiBDalyBCampbellLVChisholmDJKeoghA. Predicting the occurrence of diabetes mellitus in recipients of heart transplants. Diabet Med.2000;17(1):15–19.
25.
BloomRDRaoVWengFGrossmanRACohenDMangeKC. Association of hepatitis C with posttransplant diabetes in renal transplant patients on tacrolimus. J Am Soc Nephrol.2002;13(5):1374–1380.
26.
ArnerPGunnarssonRBlomdahlSGrothCG. Some characteristics of steroid diabetes: A study in renal-transplant recipients receiving high-dose corticosteroid therapy. Diabetes Care.1983;6(1):23–25.
27.
ArakiMFlechnerSMIsmailHR. Posttransplant diabetes mellitus in kidney transplant recipients receiving calcineurin or mTOR inhibitor drugs. Transplantation.2006;81(3):335–341.
28.
FriedmanEAShyhTPBeyerMMManisTButtKM. Post-transplant diabetes in kidney transplant recipients. Am J Nephrol.1985;5(3):196–202.
29.
HjelmesaethJSagedalSHartmannA. Asymptomatic cytomegalovirus infection is associated with increased risk of new-onset diabetes mellitus and impaired insulin release after renal transplantation. Diabetologia.2004;47(9):1550–1556.
30.
HjelmesaethJMullerFJenssenTRollagHSagedalSHartmannA. Is there a link between cytomegalovirus infection and new-onset posttransplantation diabetes mellitus? Potential mechanisms of virus induced beta-cell damage. Nephrol Dial Transplant.2005;20(11):2311–2315.
