Publications are reviewed that identify factors during donor care and characteristics of the donor liver that may be associated with outcome following liver transplantation. The procurement coordinator has the opportunity to influence cold ischemia time, blood pressure, the serum sodium concentration and, perhaps, liver glycogen reserves. These variables may significantly affect postimplantation graft performance and graft or recipient survival. Summaries of those publications comprising this database are presented, and several limitations in their interpretation are discussed.
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References
1.
StrasbergSMHowardTKMolmentiEPHertlM. Selecting the donor liver: Risk factors for poor function after orthotopic liver transplantation. Hepatology.1994;20:829–838.
2.
MaringJKKlompmakerIJZwavelingJHKranenburgKTen VergertEMSlooffMJH. Poor initial graft function after orthotopic liver transplantation: Can it be predicted and does it affect outcome? An analysis of 125 adult primary transplantations. Clin Transplant.1997;11:373–379.
3.
TulliusSGVolkHDNeuhausP. Transplantation of organs from marginal donors. Transplantation.2001;72:1341–1349.
4.
Tuttle-NewhallJECollinsBHKuoPCSchoederR. Organ donation and treatment of the multi-organ donor. Curr Probl Surg.2003;40:266–310.
5.
ShakedANunesFAOlthoffKMLuceyMR. Assessment of liver function: Pre- and peritransplant evaluation. Clin Chem.1997;43:1539–1545.
6.
GreigPDForsterJSuperinaRA. Donor-specific factors predict graft function following liver transplantation. Transplant Proc.1990;22:2072–2073.
7.
BrokelmanWStelALPloegRJ. Risk factors for primary dysfunction after liver transplantation in the University of Wisconsin solution era. Transplant Proc.1999;31:2087–2090.
8.
MimeaultRGrantDGhentCDuffJWallW. Analysis of donor and recipient variables and early graft function after orthotopic liver transplantation. Transplant Proc.1989;21:3355.
9.
PloegRJD'AlessandroAMKnechtleSJ. Risk factors for primary dysfunction after liver transplantation: A multivariate analysis. Transplantation.1993;55:807–813.
10.
FiguerasJBusquetsJGrandeL. The deleterious effect of donor high plasma sodium and extended preservation in liver transplantation. Transplantation.1996;61:410–413.
11.
AlexanderJWVaugnWK. The use of “marginal” donors for organ transplantation. Transplantation.1991;51:135–141.
12.
BricenoJMarchalTPadilloJSolorzanoGPeraC. Influence of marginal donors on liver preservation injury. Transplantation.2002;74:522–526.
13.
YersizHShakedAOlthoffK. Correlation between donor age and the pattern of liver graft recovery after transplantation. Transplantation.1995;60:790–794.
14.
BusquetsJXiolXFiguerasJ. The impact of donor age on liver transplantation: Influence of donor age on early liver function and on subsequent patient and graft survival. Transplantation.2001;71:1765–1771.
15.
KizilisikTAAl-SebayelMRamierzCB. Analysis of donor criteria and its implications on the outcome of clinical liver transplants. Transplant Proc.1997;29:2836–2838.
16.
LeeYJLeeSGKwonTWParkKMKimSCMinPC. Donor characteristics for liver transplantation and risk factors for early poor graft function and survival. Transplant Proc.1996;28:1663–1664.
17.
JonasSBechsteinWOKeckHLemmensHPBlumhardtGNeuhausP. Donor criteria in hepatic transplantation. Langenbecks Arch Chir.1994;379:8–12.
18.
GonzalezFXRimolaAGrandeL. Predictive factors of early postoperative graft function in human liver transplantation. Hepatology.1994;20:565–573.
19.
AvolioAWAgnesSMagaliniSCFocoMCastagnetoM. Importance of donor blood chemistry data (AST, serum sodium) in predicting liver transplant outcome. Transplant Proc.1991;23:2451–2452.
20.
BricenoJLopez-CilleroPRufianS. Impact of marginal quality donors on the outcome of liver transplantation. Transplant Proc.1997;29:477–480.
21.
VerranDJGurkanADilworthP. Inferior liver allograft survival from cadaveric donors >50 years of age?Clin Transplant.2001;15:106–110.
22.
OhCKSanfeyHAPelletierSJSawyerRGMcCulloughCSPruettTL. Implication of advanced donor age on the outcome of liver transplantation. Clin Transplant.2000;14:386–390.
23.
GruenbergerTSteiningerRSautnerTMittlbockMMuhlbacherF. Influence of donor criteria on postoperative graft function after orthotopic liver transplantation. Transpl Int.1994;7(suppl 1):S672–S674.
24.
TotsukaEDodsonFUrakamiA. Influence of high donor serum sodium levels on early postoperative graft function in human liver transplantation: Effect of correction of donor hypernatremia. Liver Transplant Surg.1999;5:421–428.
25.
BrooksBKLevyMFJenningsLW. Influence of donor and recipient gender on the outcome of liver transplantation. Transplant Proc.1997;29:475–476.
26.
MakowkaLGordonRDTodoS. Analysis of donor criteria for the prediction of outcome in clinical liver transplantation. Transplant Proc.1987;19:2378–2382.
27.
delaTorreANKuoPCPlotkinJS. Influence of donor base deficit status on recipient outcomes in liver transplantation. Transplant Proc.1997;29:474.
28.
KahnDMakowkaLCavalerJStarzlTEVan ThielDH. The outcome after clinical liver transplantation is influenced by the gender of the donor. Hepatology.1988;8:1225.
29.
KoneruBDikdanG. Hepatic steatosis and liver transplantation current clinicals and experimental perspectives. Transplantation.2002;73:325–330.
30.
PillaySPMooreTDLynchSVWhitingRFBaldersonGAStrongRW. Endotoxin levels in adult liver donors. Aust N Z J Surg.1994;64:615–617.
31.
PalomboJDBurkePAMoldawerLLForseRALewisWDJenkinsRL. Assessment of the cytokine response in liver donors at the time of organ procurement and association with allograft function after orthotopic transplantation. J Am Coll Surg.1994;179:209–219.
32.
SingerPCohenJCynoberL. Effect of nutritional state of brain-dead organ donor on transplantation. Nutrition.2001;17:948–952.
33.
AdamRReynesMBaoYM. Impact of glycogen content of the donor liver in clinical liver transplantation. Transplant Proc.1993;25:1536–1537.
34.
BoudjemaKLindellSLSouthardJHBelzerFO. The effects of fasting on the quality of liver preservation by simple cold storage. Transplantation.1990;50:943–948.
35.
PalomboJDHirschbergYPomposelliJJBlackburnGLZeiselSHBistrianBR. Decreased loss of liver nucleotides and energy charge during hypothermic preservation by donor pretreatment with glucose: A preliminary report. Transplant Proc.1989;21:1299–1300.
36.
LanirAJenkinsRLCaldwellCLeeRGLKhettryUClouseME. Hepatic transplantation survival: Correlation with adenine nucleotide level in donor liver. Hepatology.1988;8:471–475.
37.
CywesRGreigPDSanabriaJR. Effect of intraportal glucose infusion on hepatic glycogen content and degradation, and outcome of liver transplantation. Ann Surg.1992;216:235–247.
38.
KamikeWBurdelskiMSteinhoffGRingeBLauchartWPichlmayrR. Adenine nucleotide metabolism and its relation to organ viability in human liver transplantation. Transplantation.1988;45:138–143.
39.
PownerDJDarbyJM. Management of variations in blood pressure during care of organ donors. Prog Transplant.2000;10:25–32.
40.
PownerDJDarbyJMKellumJA. Proposed treatment guidelines for donor care. Prog Transplant. March 2004;14:16–26.
41.
CariniRAlbanoE. Recent insights on the mechanism of liver preconditioning. Gastroenterology.2003;125:1480–1489.
42.
SerafinAFernandez-ZabaleguiLPratsN. Ischemic preconditioning: Tolerance to ischemia-reperfusion injury. Histol Histopathol.2004;19:281–289.
43.
TotsukaEFungJJUrakamiA. Influence of donor cardiopulmonary arrest in human liver transplantation: Possible role of ischemic preconditioning. Hepatology.2000;31:577–580.
44.
WilsonDJFisherADasK. Donors with cardiac arrest: Improved organ recovery but no preconditioning benefit in liver allografts. Transplantation.2003;75:1683–1687.
45.
BerrevoetFSchaferTVollmarBMengerMD. Ischemic preconditioning: Enough evidence to support clinical application in liver surgery and transplantation?Acta Chir Belg.2003;103:485–489.