This case study details the use of arginine vasopressin in a pediatric organ donor. Although arginine vasopressin is primarily administered for its antidiuretic effects in the treatment of diabetes insipidus, the study demonstrates the often overlooked vasoactive effect of arginine vasopressin and its use in a patient without diabetes insipidus.
Get full access to this article
View all access options for this article.
References
1.
KissoonNFrewenTCBlochMGayleMStillerC. Pediatric organ donor maintenance: Pathophysiologic derangements and nursing requirements. Pediatrics.1989;84:688–693.
2.
NovitskyD. Detrimental effect of brain death on the potential organ donor. Transplant Proc.1997;29:3770–3772.
3.
KlineELWintersRW. Disorders of ADH. In: WinterRL, ed. The Body Fluids in Pediatrics.Boston, Mass: Little, Brown; 1973:415–437.
4.
WheatleyCH, ed. Essentials of Human Anatomy and Physiology.5th ed.Boston, Mass: William C. Brown, Publishers; 1995.
5.
Academy of Pediatrics Task Force on Brain Death in Children. Report of special task force: Guidelines for the determination of brain death in children. Pediatrics.1987;80:298–300.
6.
LevinsonMMCopelandJG. The organ donor: Physiology, maintenance and procurement considerations. Contemp Anesth Pract.1989;10:31–45.
7.
ArgenzianoMChenJCullinaneS. Arginine vasopressin in the management of vasodilatory hypotension after cardiac transplantation. J Heart Lung Transplant.1999;18:814–817.
8.
GrammHMeinholdHBickelU. Acute endocrine failure after brain death. Transplantation.1992;54:851–857.
9.
LagiewskaBPacholczykMSzostekMWalaszewskiJRowinskiW. Hemodynamic and metabolic disturbances observed in brain-dead organ donors. Transplant Proc.1996;28:165–166.
10.
MarshallRAshanNDhillonS. Adverse effects of donor vasopressor support on immediate and one year kidney allograft function. Surgery.1996;120:663–665.
11.
YoshikaTSugimotoHUenishiM. Prolonged hemodynamic maintenance by the combined administration of vasopressin and epinephrine in brain death: A clinical study. Neurosurgery.1986;18:565–567.
12.
IwaiASakanoTUenishiMSugimotoHYoshiokaTSugimotoT. Effects of vasopressin and catecholamines on the maintenance of circulatory stability in brain-dead patients. Transplantation.1989;48:613–617.
13.
PennefatherSHBullockREMantleDDarkJ. Use of low dose arginine vasopressin to support brain-dead organ donors. Transplantation.1995;59:58–62.
14.
KinoshitaYKahataKYoshiokaTOnishiSSugimotoT. Long-term renal preservation after brain death maintained with vasopressin and epinephrine. Transplant Int.1990;1:15–18.