We present the case of a middle-aged man with orbital and maxillary invasive aspergillosis on treatment with oral voriconazole, who presented with photosensitivity, cracked lips and dark-brown hyperpigmentation of face, upper chest and trunk after 4 months of treatment. Photosensitvity occurs in 10%–20% of patients on treatment with voriconazole, and may even lead to cutaneous malignancies. Patient education about the phototoxic effects of voriconazole is essential at the outset of therapy.
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HaylettAKFeltonSDenningDW, et al. Voriconazole-induced photosensitivity: photobiological assessment of a case series of 12 patients. Br J Dermatol2013; 168: 179–85.
