Abstract
We thank Dr Jolobe for his comments. The association of colorectal metastasis from gastric cancer has been well known for many years and the occurrence of gastric metastasis from colonic cancer is less common. But the metastatic spread of dysplastic cells from polyps in one site to the other site has not been described. Further, to attribute the development of a frank cancer at one site to the metastatic seeding of dysplastic cells from a polyp at the other site, and subsequent progression to cancer, has also not been described. Most occurrences of cancer at one site and polyp at the other have therefore to be regarded as synchronous rather than metastatic.
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