This short report describes a case of drug induced parkinsonism associated with the use of sodium valproate therapy as a mood stabiliser. The clinical utility of FP-CIT SPECT scanning in the differential diagnosis of parkinsonism and tremor disorders is briefly reviewed. The importance of early recognition of valproate-induced parkinsonism is emphasised since this clinical syndrome is largely reversible after drug withdrawal.
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References
1.
ArmonCCShinMillerP Reversible parkinsonism and cognitive impairment with chronic valproate use. Neurology 1996; 47:626–35.
2.
EasterfordKPCloughKellettM Reversible parkinsonism with normal Beta- CIT SPECT in patients exposed to sodium valproate. Neurology 2004; 62:1435–7
3.
BenamerHTSJPattersonDGGrosset and (123 I) FP-CIT Study Group. Accurate differentiation of parkinsonism and essential tremor using visual assessment of 123 I FP-CIT SPECT imaging. Mov Disord 2000; 15:503–10.
4.
BooijJJDSpeilmanMIMHorstink,Wolters SEC. The clinical benefit of imaging striatal dopamine transporters with 123 I FPCIT SPECT in differentiating patients with presynaptic parkinsonism from those with others forms of parkinsonism. Eur J Nucl Med 2001; 28:266–72.
5.
TolosaEStudyCUPS Group. Accuracy of 123 I – ioflupane (DaT SCAN) in the diagnosis of patients with clinically uncertain parkinsonism: A two year follow-up study. Mov Disord 2005; 20 (Suppl 10):S40; 136.
6.
OwensMJNemeroffCB.Pharmacology of valproate Psychopharmacol Bull 2003; 37(Suppl 2):17–24.