StevensonIHSAMSalemShepherdAMM.Studies on drug absorption and metabolism in the elderly. In: Crooks J, Stevenson IH, editors. Drugs and the elderly. Vol. 6. London: Macmillan; 1979; 51-63.
2.
BianchineJRLRCalimlimMorganJP Metabolism and absorption of L-3, 4 dihydroxyphenylalanine in patients with Parkinson’s disease. Ann N Y Acad Sci 1971; 179: 126-40.
3.
OchsHRDJGreenblattAllenMDEffect of age and Billroth gastrectomy on absorption of desmethyldiazepam from clorazepate. Clin Pharmacol Ther1979; 26:449-56.
4.
ForbesGBReinaJC.Adult lean body mass declines with age: some longitudinal observations. Metabolism 1970; 19(9):653-63.
5.
ShockNWDMWatkin,Yiengst MJ Age differences in water content of the body as related to basal oxygen consumption in males. J Gerontol1963; 18:1-8.
6.
CusackBJKellyO'MalleyKDigoxin in the elderly: pharmacokinetic consequences of old age. Clin Pharmacol Ther1979; 25:772-6.
7.
VestalREEAMcGuireTobinJDAging and ethanol metabolism. Clin Pharmacol Ther1977; 21:343-54.
Nation RL,Triggs EJ, Selig M. Lignocaine kinetics in cardiac patients and aged subjects. Br J Clin Pharmacol1977; 4:439-48.
11.
Christensen JH,Andreason S, Jansen JA. Pharmacokinetics and pharmacodynamics of thiopentone. Anaesthesia1982; 37:398-404.
12.
OchsHRDJGreenblattDivollMDiazepam kinetics in relation to age and sex. Pharmacology1981; 23:24-30.
13.
GreenblattDJ.Reduced serum albumin concentration in the elderly: a report from Boston Collaborative Drug Surveillance Program. J Am Geriatr Soc1979; 27:20-2.
14.
Miller AK,Adir J, Vestal RE. Tolbutamide binding to plasma proteins of young and old human subjects. J Pharm Sci 1978; 67: 1192-3.
15.
NationRLBLearoydBarberJThe pharmacokinetics of chlormethiazole following intravenous administration in the aged. Eur J Clin Pharmacol1976; 10:407-15.
16.
UptonRARLWilliamsKellyJNaproxen pharmacokinetics in the elderly. Br J Clin Pharmacol1984; 18:207-14.
17.
MatherLEGTTuckerPflugAEMeperidine kinetics in man: intravenous injection in surgical patients and volunteers. Clin Pharmacol Ther1975; 17:21-30.
18.
HayesMJMJSLangmanShortAH.Changes in drug metabolism with increasing age. II. Phenytoin clearance and protein binding. Br J Pharmacol1975; 2:73-9.
19.
NetterPGFaureRegentMCSalicylate kinetics in old age. Clin Pharmacol Ther1985; 38:6-11.
20.
AbernethyDRKerznerL.Age effects on alpha-1 -acid glycoprotein concentration and imipramine plasma protein binding. J Am Geriatr Soc1984; 32:705-8.
21.
Montamat SC, Cusack BJ, Vestal RE. Management of drug therapy in the elderly. N Engl J Med1989; 321:303-9.
22.
CallowayNOCFFoleyLagerbloomP. Uncertainties in geriatric data: organ size. J Am Geriatr Soc 1965; 13:20.
23.
GeokasMCHaverbackBH.The ageing gastrointestinal tract. Am J Surg1969; 117:881-92.
24.
WhittakerJAEvansDDP.Genetic control of phenylbutazone metabolism in man. Br Med J1970; 4:323-8.
25.
SalemSAMRajjaybun P ShepherdAMMReduced induction of drug metabolism in the elderly. Age Ageing1978; 7:68-73.
26.
CastledonCMGeorgeCF.The effect of aging on the hepatic clearance of propranolol. Br J Pharmacol I979; 7X49-54.
27.
IrvineREJGroveToselandPAEffect of age on the hydroxylation of amylobarbitone sodium in man. Br J Clin Pharmacol1975; 2:303-6.
28.
Wood AJ,Vestal RE,Wilkinson GR Effect of aging and cigarette smoking on antipyrine and indocyanine green elimination. Clin Pharmacol Ther 1979; 26: 16-20.
29.
RobertsRKGRWilkinsonBranchRAEffect of age and parenchymal liver disease on the disposition and elimination of chlordiazepoxide (Librium). Gastroenterology1978; 75:479-85.
30.
CrooksJKOmalleyStevensonIH.Pharmacokinetics in the elderly. Clin Pharmacokinet1976; 1:280-96.
31.
DivollMDRAbernathyAmeerB Acetaminophen kinetics in the elderly. Clin Pharmacol Ther 1982; 31: 151-6.
32.
MayersohnM.Drug disposition. In: Conrad KA, Bressler R, editors. Drug therapy in the elderly. St Louis: CV Mosby; 1982; 31-63.
33.
ShullHJGRWilkinsonJohnsonRNormal disposition of oxazepam in acute viral hepatitis and cirrhosis. Ann Intern Med1976; 84:420-5.
34.
PaulsenONilssonLG.Distribution of acetylator phenotype in relation to age and sex in Swedish patients. Eur J Clin Pharmacol1985; 28:311-15.
35.
RobertCASaint-AubinHouinGMetabolisme de l’isomazide chez le vieillard, consequences pratiques. Revue Geriatr1980; 5:211-6.
36.
RoweJWRAndres,Tobin JD Age-adjusted standards for creatinine clearance. Ann Intern Med1976; 84:567-9.
37.
DaviesDFAge changes in glomerular filtration rateShock NWfloweffective renal plasmaexcretorytubular capacity in adult males. J Clin Invest 1950; 29:496.
38.
HollenbergNKDFAdamsSolomonHSSenescence and the renal vasculature in normal man. Circ Res1974; 34:309-16.
39.
CockcroftDWGaultMH.Prediction of creatinine clearance from serum creatinine. Nephron 1976; 16:31 -41.
40.
ChaudhryAYRFBingCastledenCMThe effect of aging on the response to furosemide in normal subjects. Eur J Clin Pharmacol1984; 27:303-6.
41.
EpsteinMHollenbergNK.Age as a determinant of renal sodium conservation in normal man. J Lab Clin Med 1976; 87(3):411-17.
42.
PhillipsPABJRollsLedinghamJG Reduced thirst after water deprivation in healthy elderly men. N Engl J Med 1984; 311(12):753-9.
43.
CairdFIJRAndrewsKennedyRD.Effect of posture on blood pressure in the elderly. Br Heart J1973; 35:527-30.
44.
KlausnerSCSchwartzAB.The aging heart. Clin Geriatr Med 1985; 1(1):119-41.
45.
HarperCMPANewtonWalshJR.Drug-induced illness in the elderly. Postgrad Med 1989; 86(2):245-56.
46.
RayWAMRGriffinShorrRI.Adverse drug reactions and the elderly. Health Affairs 1990; 9: 114-22.
47.
SchwartzJBAbernethyDR.Cardiac drugs: adjusting their use in aging patients. Geriatrics 1987;42(8):31-40.
48.
BendF.Clinical aspects of the aging heart. Z Kardiol 1985; 74(Suppl 1):49-54.
49.
DochertyJR.Ageing and the cardiovascular system. J Auton Pharmacol1986; 6:77-84.
50.
LakattaEGGGerstenblithAngellCS Diminished inotropic response of the aged myocardium to catecholamines. Circ Res 1975; 36(2):262-9.
51.
VestalREAJWoodShandDG.Reduced β-adrenoceptor sensitivity in the elderly. Clin Pharmacol Ther 1979; 26: 181-6.
52.
StrattonJRMDCerqueiraScwartzRSDifferences in cardiovascular responses to isoproterenol in relation to age and exercise training in healthy men. Circulation1992; 86:504-12.
53.
FeldmanRDLELimbirdNadeauJL.Alterations in leucocyte beta-receptor affinity with ageing: A potential explanation for altered beta-adrenergic sensitivity in the elderly. N Engl J Med1984; 310:815-9.
54.
BertelOFRBuhlerKiowskiW Decreased beta-adrenoreceptor responsiveness as related to age, blood pressure, and plasma catecholamines in patients with essential hypertension. Hypertension 1980; 2: 130-8.
55.
PanHYMBBHoffmanPersheRADecline in beta adrenergic receptor-mediated vascular relaxation with aging in man. J Pharmacol Exp Ther1986; 239:802-7.
56.
UllahMIGBNewmanSaundersKB.Influence of age on response to ipratropium and salbutamol in asthma. Thorax 1981; 36(7):523-9.
57.
BuehlerFRFBurkartLutoldB Antihypertensive beta blocking action is related to renin and age: a pharmacologic tool to identify pathogenic mechanisms in essential hypertension. Am J Cardiol 1975; 36(5):653-69.
58.
KrallJFMConnellyWeisbartR Age-related elevation of plasma catecholamine concentrations and reduced responsiveness of lymphocyte adenylate cyclase. J Clin Endocrinol Metab 1981; 52(5):863-7.
59.
FeldmanRDLELimbirdNadeauJAlterations in leukocyte beta-receptor affinity with aging: a potential explanation for altered beta-adrenergic sensitivity in the elderly. N Engl J Med1984; 310:815-19.
60.
MeredithPAHLElliottAhmedJD Age and the antihypertensive efficacy of verapamil - integrated pharmacokinetic - pharmacodynamic approach. J Hypertension 1987; 5(Suppl 5):S219-21.
61.
AbernethyDRJBSchwartzToddELVerapamil pharmacodynamics and disposition in young and elderly hypertensive patients. Ann Intern Med1986; 105:329-36.
62.
MontamatSCAbernethyDR.Calcium antagonists in geriatric patients: diltiazem in elderly patients with hypertension. Clin Pharmacol Ther1989; 45:682-91.
63.
SchwartzJBAbernethyD. Responses to intravenous and oral diltiazem in elderly and younger patients with systemic hypertension. Am J Cardiol 1987; 59: 1111-7.
64.
LyonsDSRoyPatelM Impaired nitric oxide mediated vasodilation and total body nitric oxide production in healthy old age. Clin Sci 1997; 93(6):519-25.
65.
McGeerPLEGMcGeerSuzukiJ Aging, Alzheimer’s disease, and the cholinergic system of the basal forebrain. Neurology I984; 34(6):741-5.
66.
RinneJO.Muscarinic and dopaminergic receptors in aging human brain. Brain Res 1987; 404: 161-8.
67.
DauchotPGravensteinJS.Effects of atropine on the electrocardiogram in different age groups. Clin Pharmacol Ther1971; 12:274-80.
68.
RayPGKJMeadorLoringDW Central anticholinergic hypersensitivity in aging. J Geriatr Psych Neurol 1992; 5(2):72-7.
69.
JosephJAREBergerEngleBTAge-related changes in the nigrostriatum: a behavioral and biochemical analysis. J Gerontol1978; 33:643-9.
70.
MorganDGPCMayDopamineFinch CE.systemsserotoninin human and rodent brain: Effects of age and neurodegenerative disease. J Am Geriat Soc1987; 35:334-45.
71.
Mackay AVP Iversen LL, Rossor M Increased brain dopamine and dopamine receptors in schizophrenia. Arch Gen Psychiatry1982; 39:991-7.
72.
PalmerAMDeKoskyST.Neurochemistry. In: Pathy MSJ, editor. Principles and practice of geriatric medicine. Chichester:John Wiley &Sons Ltd; 1998.
RobinsonDSANiesDavisJMAging monoamines and monoamin oxidase. Lancet1972; 1:290-1.
75.
DeKoskySTPalmerAM.Neurochemistry of aging. In: Albert ML and Knoefel JE, editors. Clinical neurology of aging New York: Oxford University Press; 1994; 79-101.
76.
BertlerA.Occurrence and localization of catecholamines in the human brain. Acta Physiol Scand1961; 51:97-107.
77.
ArranzBAErikssonMellerupE Effect of aging in human pre- and postsynaptic serotonin binding sites. Brain Research 1993; 620(1): 163-6.
78.
Cutler NR,Zavadil III AP, Eisdorfer C Concentrations of desipramine in elderly women. Am J Psychiat 1981; 138(9): 1235-7.
79.
SalzmanC.Neuropsychopharmacology. In: Katzman R, Rowe JW, editors. Principles of geriatric neurology. Philadelphia: FA Davis; 1992; 59-72.
80.
SpokesEGSNJGarrettRossorMNDistribution of GABA in post-mortem brain tissue from control, psychotic and Huntington’s chorea subjects. J Neurol Sci1980; 48:303-13.
81.
BowenDMJASpillaneCursonG Accelerated ageing or selective neuronal loss as an important cause of dementia. Lancet 1979; i:11-14.
82.
SuharaTOInoueKobayashiK No age-related changes in human benzodiazepine receptor binding measured by PET with [IIC]Ro 15-4513. Neurosci Lett 1993; 159(1-2):207-10.
83.
EvansJGNitrazepamJarvis EH. and the elderly. Br Med J 1972; 4(838):487.
84.
KaikoRFSLWallensteinRogersAG Narcotics in the elderly. Med Clin North Am 1982; 66: 1079-89.
85.
ScottJCStanskiDR.Decreased fentanyl and alfentanil dose requirements with age: a simultaneous pharmacokinetic and pharmacodynamic evaluation. J Pharmacol Exp Ther 1987; 240(1):237-9.
86.
MeyerBRMLevinDrayerDEOptimising metoclopramide control of cisplatin-induced emesis. Ann Intern Med1984; 100:393-5.
87.
PortenoyRK.Optimal pain control in elderly cancer patients. Geriatrics 1987; 42(5):33-44.
88.
BenderAD.Pharmacologic aspects of aging: a survey of the effect of increasing age on drug activity in adults. J Am Geriatr Soc 1964; 12: 114-34.
89.
ShepherdAMMDSHewickMorelandTAAge as a determinant of sensitivity to warfarin. Br J Clin Pharmacol1977; 4:315-20.
90.
LamyPP.Drug therapy in the elderly. Pharmacy Int1986; 7:46-59.
91.
CollinsKJCDoreExton-SmithANAccidental hypothermia and impaired temperature homeostasis in the elderly. BMJ1977; 1:353-6.
92.
PowellSPSchwartzRaymentC Pharmacy-based adverse drug reaction surveillance program. Am J Hosp Pharmacy 1982; 39(11): 1963-4.
93.
FoxRHRMacGibbonDaviesLProblems of the old and the cold. BMJ1973; 1:21-4.