Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely used medication worldwide. Clinicians prescribing these drugs are aware of the contraindications and potentially serious side-effects on the upper gastrointestinal (GI) tract but there is a need for increased awareness and understanding of the effects of NSAIDs on the GI tract distal to the small bowel. Two cases of NSAID-related adverse effects on the colon are reported with a review of the literature. These patients suffered significant morbidity and an avoidable delay in the diagnosis of the condition.
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