PLANTS AGAINST MALARIA PART 2: ARTEMISIA ANNUA (QINGHAOSU OR THE SWEET WORMWOOD)

1 Lee MR. Plants against malaria. Part 1: Cinchona or the Peruvian bark. J R Coll Physicians Edinb 2002; 32:189–96.

2 Huang KC. The pharmacology of Chinese Herbs. 2nd edition Boca Raton: CRC Press; 1998; 1–14.

3Qinghaosu Antimalaria Coordinating Research Group. Antimalaria studies on qinghaosu. Chinese Med J 1979; 12:811–16.

4 Li GQ XB Guo Jin R Clinical studies on treatment of cerebral malaria with qinghaosu and its derivatives. J Trad Chinese Med 1982; 2:125–30.

5 Ying LI Yu-Lin WU. How Chinese scientists discovered Qinghaosu (Artemisinin) and developed its derivatives. What are the future perspectives? Medecine Tropicale 1998; 58(3S):45–7.

6 Hyam R Plants Pankhurst R. and their Names: A Concise Dictionary. Oxford: Oxford University Press; 1995; 40–1.

7‘Artemesis.’ In: The Concise Mythological Dictionary. London: Peerage Books; 1989; 20.

8 Vogt DD Montagne M. Absinthe: Behind the Emerald Mask. Int J of Addiction 1982; 17:1015–29.

9 Klayman DL. Qinghaosu (Artemisinin): An antimalarial drug from China. Science 1985; 228:1049–55.

10 Shwe T PT Myint Myint W Clinical studies on treatment of cerebral malaria with artemether and mefloquine. Trans R Soc Trop Med Hyg 1989; 83:489–90.

11Editorial. Rediscovering wormwood: qinghaosu for malaria. Lancet 1992; 339:649–51.

12 White NJ. Qinghaosu in Combinations. Medecine Tropicale 1998; 58:3S 85–8.

13De Vries PJ, Dien TK. Clinical pharmacology and therapeutic potential of artemisinin and its derivatives in the treatment of malaria. Drugs 1996; 52:818–36. See the section: Toxicity and Adverse Effects. 830–2.

14 Pandey AV BL Tekwani Singh RL Artemisinin, an endoperoxide antimalarial disrupts the hemoglobin catabolism and heme detoxification systems in malarial parasite. J BioI Chem 1999; 274:19383–8.

15Spillius, A. The cure the West ignored. Daily Telegraph Magazine. 1 September 2001; 50–5.

16 Utzinger J EK N’Goran N’Dri A Oral artemether for prevention of Schistosoma mansoni infection: randomised controlled trial. Lancet 2000; 355:1320–5.

17De Smet PAGM. The role of plant derived drugs and herbal medicines in health care. Drugs 1997; 54(6):808–40. See the section: New Antimalarial Agents. 811–15.

18 Hindley S SA Ward Storr RC Mechanism-based design of parasite targeted artemisinin derivatives: synthesis and antimalarial activity of new diamine containing analogues. J Med Chem 2002; 45:1052–63.