MYASTHENIA GRAVIS

1 Drachman DB. Myasthenia gravis. N Engl J Med 1994; 330:1797-810.

2 Simpson JA. Myasthenia gravis: a new hypothesis. Scott Med J 1960; 5:419-39.

3 Toyka KV DB Brachman Pestronk A Myasthenia gravis: passive Transfer from man to mouse. Science 1975; 190:397-9.

4 Drachman DB RN Adams Josifek LF Functional activities of autoantibodies to acetylcholine receptors and the clinical severity of myasthenia gravis. N Engl J Med 1982; 307:769-74.

5 Newsom-Davis J AJ Pinching Vincent A Function of circulating antibody to acetylcholine receptor in myasthenia gravis: investigation by plasma exchange. Neurology 1978; 28:266-72.

6 Buckley C D Douek Newsom-Davis J Mature, longlived CD4+ and CD8+ T cells are generated by the thymoma in myasthenia gravis. Ann Neurol 2001; 50(1):64-72.

7 Matej H B Nowakowska Kalamarz M HLA antigens and susceptibility to myasthenia gravis. Arch Immunol Ther Exp (Warsz) 1987; 35:795-801.

8 Spurkland A NE Gilhus Ronningen KS Myasthenia gravis patients with thymus hyperplasia and myasthenia gravis patients with thymoma display different HLA associations. Tissue Antigens 1991; 37:90-3.

9 Kida K M Hayashi Yamada I Heterogeneity in myasthenia gravis: HLA phenotypes and autoantibody responses in ocular and generalized types. Ann Neurol 1987; 21:274-8.

10 Evoli A AP Batocchi Lo Monaco M Clinical heterogeneity of seronegative myasthenia gravis. Neuromuscul Disord 1996; 6:155-61.

11 Matsui M H Wada Ohta M Potential role of thymoma and other mediastinal tumours in the pathogenesis of myasthenia gravis. J Neuroimmunol 1993; 44:171-6.

12 Newsom-Davis J N Willcox Schluep M Immunological heterogeneity and cellular mechanisms in myasthenia gravis. Ann NY Acad Sci 1987; 505:12-26.

13 Birmanns B T Brenner Abramsky O Seronegative myasthenia gravis: clinical features, response to therapy and synthesis of acetylcholine receptor antibodies in vitro. J Neurol Sci 1991; 102:184-9.

14 Verma PK Oger JJ. Seronegative generalized myasthenia gravis: low frequency of thymic pathology. Neurology 1992; 42:586-9.

15 Burges J A Vincent Molenaar PC Passive transfer of seronegative myasthenia gravis to mice. Muscle &Nerve 1994; 17:1393-400.

16 Mossman S A Vincent Newsom-Davis J. Myasthenia gravis without acetylcholine–receptor antibody: a distinct disease entity. Lancet 1986; 1:116-9.

17 Drachman DB S de Silva Ramsay D Humoral pathogenesis of myasthenia gravis. Ann NY Acad Sci 1987; 505:90-105.

18 Karni A E Zisman Katz-Levy Y Reactivity of T cells from seronegative patients with myasthenia gravis to T cell epitopes of the human acetylcholine receptor. Neurology 1997; 48:1638-42.

19 Sharshar T S Lacroix-Desmazes Mouthon L Selective impairment of serum antibody repertoires toward muscle and thymus antigens in patients with seronegative and seropositive myasthenia gravis. Eur J Immunol 1998; 28:2344-54.

20 Blaes F D Beeson Plested P IgG from ‘seronegative’ myasthenia gravis patients binds to a muscle cell line, TE671, but not to human acetylcholine receptor. Ann Neurol 2000; 47:504-10.

21 Barrett-Jolley R N Byrne Vincent A Plasma from patients with seronegative myasthenia gravis inhibit nAChR responses in the TE671/RD cell line. Pflugers Arch 1994; 428:492-8.

22 Li Z N Forester Vincent A. Modulation of acetyl-choline receptor function in TE671 (rhabdomyosarcoma) cells by non-AChR ligands: possible relevance to seronegative myasthenia gravis. J Neuroimmunol 1996; 64:179-83.

23 Hoch W J McConville Helms S Autoantibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies. Nat Med 2001; 7:365-8.

24 Valenzuela DM TN Stitt DiStefano PS Receptor tyrosine kinase specific for the skeletal muscle lineage: expression in embryonic muscle, at the neuromuscular junction, and after injury. Neuron 1995; 15:573-84.

25 Hopf C Hoch W. Dimerisation of the muscle-specific kinase induces tyrosine phophorylation of acetylcholine receptors and their aggregation on the surface of myotubes. J Biol Chem 1998; 273:6467-73.

26 Bowen DC JS Park Bodine S Localisation and regulation of MuSK at the neuromuscular junction. Dev Biol 1998; 199:309-19.

27 Apel ED DJ Glass Moscoso LM Rapsyn is required for MuSK signaling and recruits synaptic components to a MuSK – containing scaffold. Neuron 1997; 18:623-35.