KennedyGC. The role of depot fat in the hypothalamic control of food intake in the rat. Proc Royal Soc London1953; 140B:579–92.
2.
ColemanDL. Effects of parabiosis of obese with diabetes and normal mice. Diabetologia1973; 9:294–8.
3.
ZhangY, ProencaR, MaffeiM. Positional cloning of the mouse obese gene and its human homologue. Nature1994; 372:425–32.
4.
CintiS, FrederickRC, ZingarettiMC. Immunohistochemical localisation of leptin and uncoupling protein in white and brown adipose tissue. Endocrinology1997; 138:797–804.
5.
MasuzakiH, OgawaY, SagawaN. Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nat Med1997; 3:1029–33.
6.
BaumannH, MorellaKK, WhiteDW. The full-length leptin receptor has signalling capabilities of interleukin 6–type cytokine receptors. Proc Natl Acad Sci USA1996; 93:8374–8.
7.
AlWoods, MlStock. Leptin activation in hypothalamus. Nature1996; 381:745.
8.
KiefferTJ, HellerRS, HabenerJF. Leptin receptors expressed on pancreatic b-cells. Biochem Biophys Res Commun1996; 224:522–7.
9.
CuminF, BaumHP, LevensN. Leptin is cleared from the circulation primarily by the kidney. Int J Obes Relat Metab Disord1996; 20:l120–6.
10.
ClementK, VaissC, LahlouN. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature1998; 392:398–401.
11.
HubeF, LietzU, IgelM. Difference in leptin mRNA levels between omental and subcutaneous abdominal adipose tissue from obese humans. Horm Res1996; 28:690–3.
12.
TrayhurnP, ThomasMEA, DuncanJS. Effects of fasting and refeeding on ob gene expression in white adipose tissue of lean and obese (ob/Ob) mice. FEBS Lett1995; 368:488–90.
13.
MaffeiM, HalaasJ, RavussinE. Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med1995; 1:1155–61.
MantzorosCS, LioliosAD, TritosNA. Circulating insulin concentrations, smoking and alcohol intake are important independent predictors of leptin in young healthy men. Obesity Res1998; 6:179–85.
16.
HickeyMS, HoumardJA, ConsidineRV. Gender-dependent effects of exercise training on serum leptin levels in humans. Am J Physiol1997; 272:E562–6.
17.
RosenbaumM, NicolsonM, HirschJ. Effects of gender, body composition, and menopause on plasma concentrations of leptin. J Clin Endocrinol Metab1996; 81:3424–7.
18.
DemerathEW, TowneB, WisemandleW. Serum leptin concentration, body composition, and gonadal hormones during puberty. Int J Obes Relat Metab Disord1999; 23(7):678–85.
19.
SchwartzMW, PeskindE, RaskindM. Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nat Med1996; 2:589–93.
20.
ClaphamJC, SmithSA, MooreGBT. Plasma leptin concentrations and ob gene expression in subcutaneous adipose tissue are not regulated acutely by physiological hyperinsulinaemia in lean and obese humans. Int J Obes Relat Metab Disord1997; 21:179–83.
21.
CaroJF, SinhaMK, KolaczynskiJW. Leptin: the tale of an obesity gene. Diabetes1996; 45:1455–62.
22.
De VosP, SaladinR, AuwerxJ. Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake. J Biol Chem1995; 270:15958–61.
23.
ZakrzewskaKE, SainsburyCA, Rohner-JeanrenaudF. Glucocorticoids as counterregulatory hormones of leptin. Toward an understanding of leptin resistance. Diabetes1997; 46:717–19.
24.
UeharaY, ShimizuH, OhtaniK. Hypothalamic corticotropin-releasing hormone is a mediator of the anorexigenic effect of leptin. Diabetes1998; 47:890–3.
25.
DonahooWT, JensenTR, YostTJ. Isoproterenol and somatostatin decrease plasma leptin in humans: a novel mechanism regulating leptin secretion. J Clin Endocrinol Metab1997; 82:4139–43.
26.
MantzorosCS, QuD, FrederichRC. Activation of beta(3) adrenergic receptors suppresses leptin expression and mediates a leptin-independent inhibition of food intake in mice. Diabetes1996; 45:909–14.
27.
TrayhurnP, DuncanJS, RaynerDV. Acute cold-induced suppression on ob gene expression in white adipose tissue of mice: mediation by the sympathetic system. Biochem J1995; 311:729–33.
28.
ElmquistJK, AhimaRS, EliasCF. Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei. Proc Natl Acad Sci USA1998; 95:741–6.
29.
WolfG. Neuropeptides responding to leptin. Nutr Rev1997; 55:85–8.
30.
YuWH, KimuraM, WalczewskaA. Role of leptin in hypothalamic-pituitary function. Proc Natl Acad Sci USA1997; 94:1023–8.
31.
DalImanMF, AkanaSF, StrackAM. The neural network that regulates energy balance is responsive at a site proximal to CRF neurons. Ann NY Acad Sci1995; 771:730–42.
32.
FlierJS, Maratos-FlierE. Obesity and the hypothalamus: novel peptides for new pathways. Cell1998; 92:437–40.
33.
ThHorvath, DianoS, van den PolAN. Synaptic interaction between hypocretin (orexin) and neuropeptide Y cells in the rodent and primate hypothalamus: a novel circuit implicated in metabolic and endocrine regulations. J Neurosci1999; 19(3):1072–87.
34.
HakanssonM, de LeceaL, SutcliffeJO. Leptin receptor- and STAT3–immunoreactivities in hypocretin/orexin neurones of the lateral hypothalamus. J Neuroendocrinol1999; 11(8):653–63.
35.
BeckB, RichyS. Hypothalamic hypocretin/orexin and neuropeptide Y: divergent interaction with energy depletion and leptin. Biochem Biophys Res Commun1999; 258(1):119–22.
36.
SahuA. Evidence suggesting that galanin, melanin-concentrating hormone (MCH), neurotensin (NT), proopiomelanocortin (POMC) and neuropeptide Y (NPY) are targets of leptin signalling in the hypothalamus. Endocrinology1998; 139(2):795–8.
37.
ShimadaM, TritosNA, LowellBB. Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature1998; 396:670–4.
JanikJE, CutriBD, ConsidineRV. Interleukin la increases serum leptin concentrations in humans. Diabetologia1997; 40:348–51.
40.
BjorbaekC, ElmquistJK, FrantzJD. Identification of SOCS-3 as a potential mediator of leptin resistance. Molecular Cell1998; 1:619–25.
41.
PelleymounterMA, MlCullen, BakerMB. Effects of the obese gene product on bodyweight regulation in ob/ob mice. Science1996; 269:540–3.
42.
KiefferTJ, HellerRS, LeechCA. Suppression of insulin secretion by the activation of ATP-sensitive K channels in pancreatic b-cells. Diabetes1997; 46:1087–93.
43.
CohenB, NovickD, RubinsteinM. Modulation of insulin activities by leptin. Science1996; 274:1185–8.
44.
HanleyAJO, HarrisSB, GaoXJ. Serum immunoreactive leptin concentrations in a Canadian aboriginal population with high rates of NIDDM. Diabetes Care1997; 20(9):1408–15.
45.
McoregorOP, DesagaJF, EhlenzK. Radioimmnunological measurement of leptin in plasma of obese and diabetic human subjects. Endocrinology1996; 137:1501–4.
46.
TuominenJA, EbelingP, StenmanUH. Leptin synthesis is resistant to acute effects of insulin in insulin-dependent diabetes mellitus patients. J Clin Endocrinol Metab1997; 82:381–2.
47.
Garcia-MayorRV, AndradeMA, RiosM. Serum leptin levels in normal children: relationship to age, gender, body mass index, pituitary-gonadal hormones, and pubertal stage. J Clin Endocrinol Metab1997; 82:2849–55.
48.
MantzorosCS, FlierJS, RogolAD. A longitudinal assessment of hormonal and physical alterations during normal puberty in boys. V: Rising leptin levels may signal the onset of puberty. J Clin Endocrinol Metab1997; 82:1065–70.
49.
AhimaR, DushayJ, FlierS. Leptin accelerates the timing of puberty in normal female mice. J Clin Invest1997; 99:391–5.
50.
RouruJ, AnttilaL, KoskinenP. Serum leptin concentrations in women with polycystic ovary syndrome. J Clin Endocrinol Metab1997; 82:1697–700.
51.
LaughlinOA, AlMorales, YenSSC. Serum leptin levels in women with polycystic ovary syndrome: the role of insulin resistance / hyperinsulinemia. J Clin Endocrinol Metab1997; 82:1692–6.
52.
BrzechffaPR, JakimiukJ, AgarwalSK. Serum immunoreactive leptin concentrations women with polycystic ovary syndrome. J Clin Endocrinol Metab1996; 81:4166–9.
53.
YorkDA, OttoW, TaylorTO. Thyroid status of obese (ob/ob) mice and its relationship to adipose tissue metabolism. Comp Biochem Physiol1078; 590:59–65.
54.
MontagneCT, FarooqiIS, WhiteheadJP. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature1997; 387:903–8.
GrinspoonS, GulickT, AskariH. Serum leptin levels in women with anorexia nervosa. J Clin Endocrinol Metab1996; 81:3861–3.
57.
MantzorosCS, FlierJS, LesemMD. Cerebrospinal fluid in anorexia nervosa: correlation with nutritional status and potential role in resistance to weight gain. J Clin Endocrinol Metab1997; 82:1845–51.
58.
StouthardJM, Oude-ElferinkRP, SauerweinHP. Interleukin-6 enhances glucose transport in 3T3–L1 adipocytes. Biochem Biophys Res Commun1996; 220:241–5.
59.
WangCN, O'BrienL, BrindleyDN. Effects of cell-permeable ceramides and tumor necrosis factor-α on insulin signaling and glucose uptake in 3T3–L1 adipocytes. Diabetes1998; 47:24–31.
60.
HaunerH, PetruschkeT, RussM. Effects of tumour necrosis factor alpha (TNFα) on glucose transport and lipid metabolism of newly-differentiated human fat cells in cell culture. Diabetologia1995; 38:764–71.
61.
RitchieDG. Interleukin-6 stimulates hepatic glucose release from prelabeled glycogen pools. Am J Physiol1990; 258:E57–64.
62.
StouthardJM, RomijnJA, Van-der-PollT. Endocrinologic and metabolic effects of interleukin-6 in humans. Am J Physiol1995; 268:E813–9.
63.
KernPA, SaghizadehM, OngJM. The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. J Clin Invest1995; 95:2111–9.
64.
HotamisligilGS, ArnerP, CaroJF. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest1995; 95:2409–15.
65.
HotamisligilGS, PeraldiP, BudavariA. IRS-1 mediated inhibition of insulin receptor tyrosine kinase activity in TNF- alpha- and obesity-induced insulin resistance. Science1996; 271:665–8.
66.
StephensJM, LeeJ, PilchPF. Tumor necrosis factor-alpha-induced insulin resistance in 3T3–L1 adipocytes is accompanied by a loss of insulin-receptor substrate 1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction. J Biol Chem1997; 272:971–6.
67.
MorohoshiM, FujisawaK, UchimuraI. Glucose-dependent interleukin 6 and tumor necrosis factor production by human peripheral blood monocytes in vitro. Diabetes1996; 45:954–9.
68.
SayeedMM. Alterations in calcium signaling and cellular responses in septic injury. New Horiz1996; 4:72–86.
69.
del AguilaLF, ClaffeyKP, KirwanJP. TNF-alpha impairs insulin signaling and insulinstimulation of glucose uptake in C2C12 muscle cells. Am J Physiol1999; 276(5 Pt 1):E849–55.
70.
HansenLL, IkedaY, OlsenGS. Insulin signaling is inhibited by micromolar concentrations of H(2)O(2). Evidence for a role of H(2)O(2) in tumor necrosis factor alpha-mediated insulin resistance. J Biol Chem1999; 274(35):25078–84.
71.
BruysekL, HoustekJ. Beta-adrenergic stimulation of interleukin-1 alpha and interleukin-6 expression in mouse brown adipocytes. FEBS Lett1997; 41:83–6.
72.
van-der-PollT, JansenJ, EndertE. Noradrenaline inhibits lipopolysaccharide-induced tumor necrosis factor and interleukin-6 production in human whole blood. Infect Immun1994; 62:2046–50.
73.
GreenbergAS, NordonRP, McIntoshJ. Interleukin-6 reduces lipoprotein lipase activity in adipose tissue of mice in vivo and in 3T3–L1 adipocytes: a possible role for interleukin-6 in cancer cachexia. Cancer Res1992; 52:4113–6.
74.
MatthysP, BilliauA. Cytokines and cachexia. Nutrition1997; 13:763–70.
75.
GrunfeldC, ZhaoC, FullerJ. Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters. J Clin Invest1996; 97:2152–7.
76.
MedinaEA, StanhopeKL, MizunoTM. Effect of tumor necrosis factor alpha on leptin secretion and gene expression: relationship to changes of glucose metabolism in isolated rat adipocytes. Int J Obes Relat Metab Disord1999; 23(8):896–903.
77.
JonesTH, KennedyRL. Cytokines and hypothalamic-pituitary function. Cytokine1993; 5:531–8.
78.
RothwellNJ. CNS regulation of thermogenesis. Crit Rev Neurobiol1994; 8: 1–10.
79.
Navarra P, Tsagarakis S, Faria MS et al. Interleukins-1 and -6 stimulate the release of corticotropin-releasing hormone-41 from rat hypothalamus in vitro via the eicosanoid cyclooxygenase pathway. Endocrinology1991; 128:37–44.
80.
LysonK, McCannSM. Induction of adrenocorticotropic hormone release by interleukin-6 in vivo and in vitro. Ann NY Acad Sci1992; 650:182–5.
81.
EbisuiO, FukataJ, MurakamiN. Effect of interleukin-1 receptor antagonist and antiserum to TNF-α on LPS-induced plasma ACTH and corticosterone rise in rats. Am J Physiol1994; 266:E986–92.
82.
KageyamaK, WatanobeH, TakebeK. In vivo evidence that arginine vasopressin is involved in the adrenocorticotropin response induced by interleukin-6 but not by tumor necrosis factor-alpha in the rat. Neuroimmunomodulation1995; 2:137–40.
TsigosC, PapanicolaouDA, DefensorR. Dose effects of recombinant human interleukin-6 on pituitary hormone secretion and energy expenditure. Neuroimmunology1997; 66:54–62.
85.
KennedyJA, WellbyML, ZottiR. Effect of interleukin-1 beta, tumour necrosis factor-alpha and interleukin-6 on the control of thyrotropin secretion. Life Sci1995; 57:487–501.
86.
OzawaM, SatoK, HanDC. Effects of tumor necrosis factor-α/cachectin on thyroid hormone metabolism in mice. Endocrinology1988; 123:1461–7.
87.
SatoK, SatohT, ShizumeK, OzawaM. Inhibition of I125 organification and thyroid hormone release by interleukin-1, tumor necrosis factor-1, tumor necrosis factor-α and interferon-γ in human thyrocytes in suspension cultures. J Clin Endocrinol Metab1990; 70:1735–43.
88.
RandlePJ, GarlandPB, HalesCN. The glucose fatty acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet1963; 1:785–9.
89.
FraynKN. Role of non-esterified fatty acids in the metabolic changes of obesity. Int J Obes1996; 20(Suppl 4):7–10.
90.
AmriEZ, TeboulL, VannierC. Fatty acids regulate the expression of lipoprotein lipase gene and activity in preadipose and adipose cells. Biochem J1996; 314:541–6.
91.
RadeauT, RobbM, McDonnellM. Preferential expression of Cholesteryl ester transfer protein mRNA by stromal-vascular cells of human adipose tissue. Biochimica et Biophysica Acta1998; 1392(2–3):245–53.
92.
ShenGX, CaiW, AngelA. Increased secretion of Cholesteryl ester transfer protein from hamster adipose tissue: stimulation by beta-adrenergic agents. Atherosclerosis1998; 140(1):113–20.
93.
AlessiMC, PeirettiF, MorangeP. Production of plasminogen activator inhibitor 1 by human adipose tissue: possible link between visceral fat accumulation and vascular disease. Diabetes1997; 46(5):860–7.
94.
MorangePE, AubertJ, PeirettiF. Glucocorticoids and insulin promote plasminogen activator inhibitor 1 production by human adipose tissue. Diabetes1999; 48(4):890–5.
95.
Juhan-VagueI, AlessiMC. PAI-1, obesity, insulin resistance and risk of cardiovascular events. Thromb Haemost1997; 78:656–60.
96.
De MitrioV, De PergolaG, VettorR. Plasma plasminogen activator inhibitor-1 is associated with plasma leptin irrespective of body mass index, body fat mass, and plasma insulin and metabolic parameters in premenopausal women. Metabolism: clinical and experimental1999; 48(8):960–4.
97.
CigoliniM, TonoliM, FrigottoL. Expression of plasminogen activator inhibitor-1 in human adipose tissue: a role for TNF- alpha?Atherosclerosis1999; 143(1):81–90.
98.
SakamotoT, Woodcock-MitchellJ, MarutsukaK. TNF-alpha and insulin, alone and synergistically, induce plasminogen activator inhibitor-1 expression in adipocytes. Am J Physiol1999; 276(6 Pt 1):C1391–7.
99.
SawdeyMS, LoskutoffDJ. Regulation of murine type1 plasminogen activator inhibitor gene expression in vivo: tissue specificity and induction by lipopolysaccharide, tumor necrosis factor-α, and transforming growth factor-βJ Clin Invest1991; 88:1346–53.
100.
JonesBH, StandridgeMK, TaylorJW. Angiotensinogen gene expression in adipose tissue: analysis of obese models and hormonal and nutritional control. Am J Physiol1997; 273(1 Pt 2):R236–42.
101.
PedersenSB, FuglsigS, SjogrenP. Identification of steroid receptors in human adipose tissue. Eur J Clin Invest1996; 26:1051–6.
102.
TchernofA, DespresJP, BelangerA. Reduced testosterone and adrenal C19 steroid levels in obese men. Metab: Clin Exp1995; 44:513–9.
103.
BjörntorpP. The regulation of adipose tissue distribution in humans. Int J Obes1996; 20:291–302.
104.
PriceTM, O'BrienSN. Determination of estrogen messenger ribonucleic acid (mRNA) and cytochrome P450 aromatase mRNA levels in adipocytes and adipose stromal cells by competitive polymerase chain reaction amplification. J Clin Endocrinol Metab1993; 77(4):1941–5.
105.
MakoverA, SopranoDR, WyattML. Localization of retinol-binding protein messenger RNA in the rat kidney and in the perinephric fat tissue. J Lipid Res1992; 267(3):1805–10.
106.
OkunoM, CaraveoVE, GoodmanDS. Regulation of adipocyte gene expression by retinoic acid and hormones: effects on the gene encoding cellular retinol-binding protein. J Lipid Res1995; 36(1):137–47.
107.
SamadF, YamamotoK, LoskutoffDJ. Elevated expression of transforming growth factor-beta in adipose tissue from obese mice. J Mol Med1997; 3(1):37–48.
108.
YamashitaH, SatoN, KizakiT. Norepinephrine stimulates the expression of fibroblast growth factor-2 in rat brown adipocyte primary culture. Cell Growth Differ1995; 6(11):1457–62.
109.
DarimontC, VassauxG, AilhaudG. Differentiation of preadipose cells: paracrine role of prostacyclin upon stimulation of adipose cells by angiotensin-II. Endocrinology1994; 135(5):2030–6.