Wolfram syndrome: DIDMOAD

Wolfram DJ Diabetes mellitus and simple optic atrophy among siblings. Proc Mayo Clinic 1938;13:715-18.

Simsek E. , Simsek T. , Tekgul S. , Hosal S. , Seyrantepe V. , Aktan G. Wolfram (DIDMOAD) syndrome: a multidisciplinary clinical study in nine Turkish patients and review of the literature. Acta Paediatr 2003;92:55-61.

Peden NR , Gay JD , Jung RT , Kuwayti K. Wolfram (DIDMOAD) syndrome: a complex long-term problem in management . Q J Med 1986;58:167-80.

Strom TM , Hortnagel K. , Hofmann S. et al. Diabetes insipidus, diabetes mellitus, optic atrophy and deafness (DIDMOAD) caused by mutations in a novel gene (wolframin) coding for a predicted transmembrane protein. Hum Mol Genet 1998;7:2021-8.

Inoue H. , Tanizawa Y. , Wasson J. et al. A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome). Nat Genet 1998;20: 143-8.

Smith CJ , Crock PA , King BR , Meldrum CJ , Scott RJ Phenotype-genotype correlations in a series of wolfram syndrome families . Diabetes Care 2004;27:2003-09.

Kodo K. , Koks S. , D Nikopensius T. et al. Polymorphisms in wolfram (WFS1) gene are possibly related to increased risk for mood disorders. Int J Neuropsychopharmacy 2004; 11:1-10. Neuropsychopharmacol 2004;11:1-10.

Domenech E. , Kruyer H. , Gomez C. , Calvo MT , Nunes V. First prenatal diagnosis for Wolfram syndrome by molecular analysis of the WFS1 gene. Prenatal Diagn 2004;24:787-9.