This article considers data from the Steno-2 multifactorial intervention study in type 2 diabetes to which are applied the United Kingdom Prospective Diabetes Study (UKPDS) risk engine. Mathematical analyses support the use of a `polypill' to reduce cardiovascular risk in type 2 diabetes. It is suggested that the Polypill should include a statin, antihypertensive agents and aspirin.
Wald NJ, Law MRA strategy to reduce cardiovascular disease by more than 80%. BMJ2003;326:1419-23.
2.
Gæde P., Vedel P., Larsen N., Jensen GVH, Parving H-H., Pedersen O.Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes. N Engl J Med2003;348:383-93.
3.
UKPDS Cardiac Risk calculator at dtu@ox.ac.uk
4.
Dinneen SF, Gerstein HCThe association of microalbuminuria and mortality in non-insulin-dependant diabetes mellitus. A systematic overview of the literature. Arch Int Med1997;157:1413-18.
5.
Patel V., Morrissey J.The Alphabet Strategy: the ABC of reducing diabetes complications . Br J Diabetes Vasc Dis2002;2(1):58-9.
6.
Jaiveer K., Saraswathy J., Lee JD, Morrissey J., Patel V.Can Steno-2 multifactorial intervention study and UKPDS standards be achieved in a District General Hospital in the UK?Diabetologia2003;46:(suppl 2): A103.
7.
Jaiveer P., Sarawathy J., Lee JD, Morrissey J., Patel V.The Alphabet strategy - a tool to achieve clinical trial standards in routine practice?Br J Diabetes Vasc Dis2003;3:410-13.
