Effect of losartan on insulin sensitivity and serum lipids in hypertensive type 2 diabetic patients

Abstract

Background Insulin resistance and hypertension are common co-existing conditions. Antihypertensive agents have differing effects on insulin sensitivity (SI). We studied 11 mildly hypertensive insulin-resistant type 2 diabetic patients to observe any changes in SI, glucose effectiveness (SG), serum total cholesterol, serum triglycerides and blood pressure (BP) with the introduction of the angiotensin II inhibitor, losartan.

Methods To assess SI and SG, we used the frequently sampled, intravenous glucose tolerance test with minimal model analysis prior to and after three months treatment with losartan potassium 50—100 mg daily. BP was assessed using a Space Labs 24-hour BP recording device before, during and after treatment with losartan.

Results There were no significant differences in SI and SG pre-and post-treatment, however, there was a non-significant reduction in mean BP, total cholesterol and triglyceride concentrations.

Conclusion There were no adverse effects of losartan on SI or SG. The lower but non-significant serum total cholesterol and triglyceride concentrations warrant further study.