The incidence and impact of implantable cardioverter defibrillator shocks in the last phase of life: An integrated review

Abstract

Background:

Although the implantable cardioverter defibrillator is successful in terminating life threatening arrhythmias, it might give unwanted shocks in the last phase of life if not deactivated in a timely manner.

Aims:

This integrated review aimed to provide an overview of studies reporting on implantable cardioverter defibrillator shock incidence and impact in the last phase of life.

Methods and results:

We systematically searched five electronic databases. Studies reporting on the incidence and/or impact of implantable cardioverter defibrillator shocks in the last month of life were included. Fifteen studies were included. Two American studies published in 1996 and 1998 reported on the incidence of shocks in patients who died non-suddenly: incidences were 24% and 33%, respectively, in the last 24 hours, and 7% and 14%, respectively, in the last hour of life. Six American studies and one Danish study published between 1991–1999 reported on patients dying suddenly: incidences were 41% and 68% in the last 24 hours and 22–66% in the last hour. Four American studies and two Swedish studies published between 2004–2015 did not distinguish the cause of death: incidences were 17–32% in the last month, 3–32% in the last 24 hours, and 8% and 31% in the last hour of life. Three American studies published between 2004–2011 reported that shocks in dying patients are painful and distressing for patients, and distressing for relatives and professional caregivers.

Conclusion:

If the implantable cardioverter defibrillator is not deactivated in a timely manner, a potentially significant proportion of implantable cardioverter defibrillator patients experience painful and distressing shocks in their last phase of life.

Keywords

Implantable cardioverter defibrillator shock end-of-life care impact integrated review

Introduction

During the last phase of life, goals of care usually shift from prolonging life to maintaining quality of life.¹ Many patients with heart failure eventually die due to progression of their underlying heart condition, despite the many treatments that are currently available.² Whether certain life-sustaining treatments are still appropriate in this last phase of life is an important topic of discussion. The implantable cardioverter defibrillator (ICD) is one of these life prolonging treatments that may pose difficult dilemmas in the last phase of life. The ICD is currently the treatment of choice in patients who are at risk of sudden cardiac death because of ventricular arrhythmias.³ In Europe, more than 85.000 ICDs were implanted in 2013, based on 46 countries, mainly in Western Europe.⁴ The number of new implants is still increasing, due to both an ageing population and expanding of the indication for ICD implantation, shifting from secondary prevention (implantation in patients that already have experienced life-threatening arrhythmias or aborted cardiac death) to primary prevention (implantation in patients with an elevated risk of arrhythmias or cardiac death who have not yet experienced such an episode).⁵

Although the ICD is effective in prolonging life, it poses challenges to the patient, such as (fear of) experiencing painful shocks and feelings of helplessness, because of the unpredictable nature of the arrhythmia and subsequent shocks.⁶ During the last phase of life, the benefits of the ICD may no longer outweigh these challenges and it may be important to discuss whether or not to deactivate the device.¹ However, such discussions can be challenging and complex for healthcare professionals, patients, and their relatives.

It is however unclear to what extend ICD patients experience shocks in the last phase of life, and what the impact of these shocks is, specifically at the end of life, on the patient, the patient’s relatives and the professional caregivers. Therefore, the following research questions will be addressed: (a) what is the incidence of appropriate and inappropriate ICD shocks in the last phase of life?; and (b) what is the impact of ICD shocks in the last phase of life on patients, their relatives, and their professional caregivers?

Methods

Data sources and search strategy

Research questions, search strategy and inclusion criteria were specified in advance and documented in a protocol. A search query was developed to identify relevant papers. In August 2016, we systematically searched five electronic scientific databases: Embase, Medline, Cochrane Central, Web of Science and Google Scholar. In order to find all relevant literature, we did not place a limitation on year of publication, all articles up to August 2016 were considered for inclusion. Studies were identified with the following keywords: defibrillator, defibrillator pacemaker, implantable cardioverter defibrillator, internal defibrillator, ICD, AICD; and shock, electric shock, electroshock, countershock, cardioversion, convulsive therapy; and terminal care, terminally ill patient, EOL, death, dying, palliative, hospice, last phase, last year, last month, last week, last day. Boolean operators were used in between key words. The detailed search queries can be found in Supplementary Material Appendix 1.

Study selection and eligibility criteria

Articles were reviewed by RS and AB via a stepwise procedure according to the PRISMA guidelines.⁷ First, studies were screened on title and abstract. Selected studies were subsequently reviewed on full text and either included or excluded. In case of disagreement, consensus was sought and achieved. Table 1 describes the inclusion and exclusion criteria. Studies were included when they reported on deceased patients with an active ICD in the last phase of life, either on the incidence of ICD shocks or on the impact of shocks on patients, relatives or professional caregivers. The last phase of life was operationalised as the last month preceding death. This was based on a study that reported on shocks one month before death.⁸ Relatives were not limited to family members but could also include others, such as close friends or other loved ones. Studies had to be written in English, and the full-text of the article had to be available. Studies were excluded when they reported on minors or were case reports. References lists from the included studies were examined to identify additional relevant studies.

Table 1.

Inclusion and exclusion criteria.

Inclusion criteria
1. Studies are empirical (both quantitative and qualitative) and report on deceased ICD patients that had an active ICD in the last month preceding death.
2. Studies report on the incidence and/or impact of ICD shocks in the last month preceding death.
3. Studies are in English.
Exclusion criteria
1. Studies in minors (<18 years of age).
2. Study is a case report.
3. Full text unavailable.

ICD: implantable cardioverter defibrillator.

Data extraction

Data of the studies that were included in the review were extracted via an extraction form. This form was developed by RS, AB and JR and piloted by RS and AB. The eventual data extraction was completed by RS.

The following data were extracted:

Shock incidence, where possible stratified by type of death. Type of death could be non-sudden death (NSD), defined as death occurring more than one hour after the onset of new symptoms, or sudden death (SD), defined as death that occurs less than one hour after the onset of new symptoms.⁹ Shock incidence was calculated by dividing the number of patients in a specific group receiving shocks by the total number of patients in that group.

Timing of shocks, categorised in three time periods: the last month, the last 24 hours and the last hour preceding death. When a study reported on multiple time periods, patients who experienced shocks during the last hour or last 24 hours preceding death were also included in the incidence in the last 24 hours and last month before death.

Appropriateness of shocks. An appropriate shock was defined as a shock for ventricular tachycardia (VT) or ventricular fibrillation (VF). An inappropriate shock was defined as any shock not delivered for VT or VF.

Impact of shocks on either patients, relatives, or professional caregivers. All available data were extracted.

Characteristics of the study, such as year of publication, study design, aim, year of implantation, year of death, and characteristics of the participants.

Quality assessment

Methodological quality was assessed with the Quality Assessment Tool.¹⁰ Via this tool, studies were evaluated regarding nine items: abstract and title, introduction and aims, methods and data, sampling, data analyses, ethics and bias, results, generalisability, and implications. Each criterion was scored on a four-point Likert scale, ranging from one (very poor) to four (good). In total, a summed score of 9–36 was calculated (9=very poor, 36=good). Studies with scores between 30–36 were assessed as high quality, studies with scores between 24–29 were assessed as moderate quality, and scores lower than 23 were assessed as low quality. Studies were not excluded based on their methodological quality.

Results

The search yielded a total of 4246 studies. We removed 1875 duplicates. All titles and abstracts were reviewed, after which 82 articles were available for full text assessment. Eventually, we included 15 studies (see Figure 1), comprising a total population of 1362 (range 4–558) patients. All studies were observational. The majority of the studies were conducted in the USA (12), the remainder in Europe (three). A total of 12 studies reported solely on shock incidence (80%), two solely on the impact of shocks (13%) and one on both the incidence and impact of shocks (7%) (see Table 2). Studies scored moderate to high on methodological quality (Tables 3 and 4). No additional studies were identified after examination of the reference lists of the included articles.

Figure 1.

Flow diagram of literature search to identify articles reporting on the incidence and/or the impact of implantable cardioverter defibrillator (ICD) shocks in the last phase of life.

Table 2.

Characteristics of the included studies (n=15).

Study characteristics		n (%)
Type of study	Quantitative	15	(100%)
Country	USA	12	(80%)
	Sweden	2	(13%)
	Canada	1	(7%)
	Denmark	1	(7%)
	New Zealand	1	(7%)
Study on	Shock incidence	13	(87%)
	Impact	3	(20%)
Number of patients in study	0–50	7	(47%)
	50–100	7	(47%)
	>100	1	(7%)

Table 3.

Information on studies reporting on implantable cardioverter defibrillator (ICD) shock incidence at the end of life.

Author	Year of publication	Year of implantation	Year of death	Country	Study design	Grade^a	Patient population (n)	Shock incidence^b			Shock type
Author	Year of publication	Year of implantation	Year of death	Country	Study design	Grade^a	Patient population (n)	30d	24h	1h	Shock type
Pratt et al.¹¹	1996	^c	1990–1994	USA	Observational Longitudinal Prospective	31	NSD (51) SD (17) NCD (40)	– – –	24% 41% 20%	14% 29% 8%	–
Grubman et al.¹²	1998	1989–1993	1989–1995	USA	Observational Cross-sectional Retrospective	32	NSD (55) SD (28) NCD (36)	– – –	33% 68% –	7%^d 22%^d 3%	Appropriate
Lehmann et al.¹³	1994	1982–1988	^c	USA	Observational Cross-sectional Retrospective	27	SD (32)	–	–	66%	–
Mosteller et al.¹⁴	1991	1982–1988	1982–1988	USA	Observational Cross-sectional Retrospective	29	SD (5)	–	–	60%	–
Pires et al.¹⁵	1999	1990–1996	^c	USA	Observational Cross-sectional Retrospective	33	SD (60)	–	–	62%^d	–
Nielsen et al.¹⁶	1997	1989–1996	^c	Denmark	Observational Longitudinal Prospective	28	SD (4)	–	–	50%^d	Appropriate
Gross et al.¹⁷	1991	1982–1990	1982–1990	USA	Observational Longitudinal Retrospective	31	SD (5)	–	–	40%^d	–
Westerdahl et al.¹⁸	2015	1998–2010	2003–2010	Sweden	Observational Cross-sectional Prospective	34	All deaths (42)	–	24%	–	–
Sherazi et al.¹⁹	2013	1997–2001	1997–2001	USA	Observational Longitudinal Retrospective	31	All deaths (83)	17–32%	3–19%	–	–
Westerdahl et al.²⁰	2014	1998–2010	2003–2010	Sweden	Observational Cross-sectional Prospective	33	All deaths (97)	–	32%	31%^e	13% Inappropriate in last 24 h
Lewis et al.²¹	2006	^c	1994–2004	USA	Observational Longitudinal Retrospective	28	All deaths (43)	21%	–	–	–
Goldstein et al.⁸	2004	^c	1997–2002	USA	Observational Cross-sectional Retrospective	31	All deaths (100)	27%	–	8%^d	–
Poole et al.²²	2008	1997–2001	^c	USA/ Canada/ New Zealand	Observational Longitudinal Retrospective	29	All deaths (64)	–	31%	–	Appropriate

1h: last hour before death; 24h: last 24 hours before death; 30d: last month before death; NSD: nonsudden death; SD: sudden death; NCD: noncardiac death.

Score classification on Quality Assessment Tool:¹⁰ 30–36=high quality; 24–29=moderate quality; <23=low quality.

Reported as time period before death.

Unknown.

Shocks were actually in the last minutes before death.

n=87.

Table 4.

Information on studies reporting on implantable cardioverter defibrillator (ICD) shock impact at the end of life.

Author	Year of publication	Country	Study design	Grade^a	Respondents	Reporting impact on	Number of patients	Outcome
Kelley et al.²³	2009	USA	Observational Cross-sectional Retrospective	33	Physicians	Patient and relatives (loved ones)	558^b	Seventy-six per cent of physicians believed that shocks at the end of life are distressing for both patient and their loved ones
Fromme et al.²⁴	2011	USA	Observational Cross-sectional Retrospective	32	Hospice administrator	Patient, relatives (family members) and professional caregivers	42^c	In 96% of cases, shocks were distressing to the patient and/or relatives. Also, present professional caregivers were distressed by shocks
Goldstein et al.⁸	2004	USA	Observational Cross-sectional Retrospective	31	Relatives	Relatives (next of kin)	100	Shocks were distressing to witness for the next of kin.

Score classification on Quality Assessment Tool:¹⁰ 30–36=high quality; 24–29=moderate quality; <23=low quality.

These are the number of physicians reporting on patients, not the actual number of patients.

These are the numbers of hospices who participated in the study, not the actual number of patients.

Incidence of ICD shocks

A total of 13 studies reported on shock incidence (Table 3). The year of publication ranged from 1991–2015. A prospective and a retrospective study, both high quality studies published in 1996 and 1998, reported on shock incidence in NSD patients.^11,12 All deaths were of cardiac origin. In these studies, 24% and 33% of patients respectively experienced one or more shocks in the last 24 hours, and 14% and 7% experienced one or more shocks in the last hour preceding death. One study reported on the appropriateness of the shocks,¹² and found that all shocks were appropriate.

Seven studies reported on shock incidence in SD patients.^11–17 Year of publication ranged from 1991–1999. Studies scored moderate to high on methodological quality. All deaths were cardiac of origin. Two studies reported on shock incidence in the last 24 hours preceding death,^11,12 one prospective study showed an incidence of 41%, a retrospective study showed an incidence of 68%. All seven studies reported on shock incidence in the final hour of life, showing an incidence ranging from 22–66%. One study reported on the appropriateness of the shocks,¹⁶ and found that all shocks were appropriate.

Two studies from 1996 and 1998 specifically reported on patients dying of noncardiac causes.^11,12 The first study showed that 20% of patients dying of a noncardiac cause experienced shocks in the last 24 hours, and 8% experienced a shock in the last hour preceding death.¹¹ The second study showed that one out of 36 patients (3%) experienced a shock in the final hour of life.¹²

In six studies, the type of death was not specified.^8,18–22 Year of publication ranged from 2004–2015 and all studies scored moderate to high on methodological quality. Three of these studies reported that 17–32% of patients experienced shocks in the last month of life.^8,19,21 Four studies showed that in the last 24 hours of life, 3–32% of patients experienced shocks.^18–20,22 Two studies showed that in the last hour of life, 8% and 31% of patients experienced shocks.^8,20 Two studies reported on the appropriateness of the shocks.^20,22 In one study, all shocks were appropriate.²² In the other study,²⁰ four of the 31 patients (13%) receiving shocks in the last 24 h were shocked inappropriately.

Impact of ICD shocks

A total of three studies reported on the impact of shocks in the last phase of life (Table 4). Date of publication ranged from 2004–2011. All studies were quantitative.^8,23,24

Impact of shocks on patients

Two studies reported on the impact of shocks on patients in the last phase of life.^23,24 In these studies, physicians and hospice administrators were surveyed. In the first study, physicians were asked whether they thought shocks are distressing to the patient. Seventy-six per cent agreed with this statement.²³ In the second study, hospice administrators reported that 74% of patients receiving shocks in the last phase of life were distressed by these shocks.²⁴

Impact of shocks on relatives

Three studies reported on the impact of shocks on relatives.^8,23,24 In one study,⁸ 100 next of kin were surveyed. The next of kin who witnessed the patient being shocked at the end of life reported that this was distressing to see. One relative reported in an interview that the patient experienced shocks every 20 minutes at the end of life, and reported it was like seeing the patient wake up from a ‘really bad dream type of thing’, after which the patient lost consciousness again. In a survey study, 76% of physicians agreed with the statement that shocks in patients at the end of their lives are distressing for the patients’ loved ones.²³ A study in hospices reported that 92% of family members of patients receiving shocks found this distressing to witness. In one case, a patient experienced shocks during the dying process and, immediately after, the nurse had to wrap her body around the patient to stop the flailing of the body, which was distressing to witness.²⁴

Impact of shocks on professional caregivers

One survey study reported on the impact of shocks on professional caregivers.²⁴ Shocks were not only distressing for the hospice team to witness, but they must also deal with pain and panic induced by the shocks and loss of control in the patient and family. In the study, a situation was reported by a hospice administrator in which a patient was shocked multiple times during dying. The body was lifted off the bed due to the force of the shocks, which was disturbing for the nurse to witness.²⁴

Discussion

This review suggests that shocks in the last month of life are common in patients with active ICDs. An important finding of this review is that of patients dying non-suddenly, a quarter to a third experienced shocks in the last 24 hours of life. In patients dying suddenly, this was a third up to nearly 70%. The number of studies on the impact of shocks in the last month of life on patients, relatives and professional caregivers was limited, but they suggest that shocks are painful for the patient and distressing for patients, relatives and professional caregivers.

While the shock incidences found in this review are rather high, we found some variation between studies. There are several possible explanations for this variation. First, studies reporting on SD patients seem to report higher shock incidences than studies reporting on NSD patients.^11–17 This is because patients in these studies mostly died of sudden cardiac causes, predominantly due to VT¹⁴ or VF,¹⁶ resulting in the ICD delivering shocks. In patients dying non-suddenly, death is less often the direct result of a tachyarrhythmia, but rather of the underlying heart disease or bleeding, resulting in the ICD intervening less often. Second, the indication for ICD implantation has shifted over time. Seven studies reported on patients who had their ICD implanted before the year 2000. In this period, ICDs were mainly implanted in patients for secondary prevention. These patients have a higher risk of recurrent VTs than patients with ICDs for primary prevention, leading to higher shock incidences.²⁰ From 2006 onwards, primary prevention was more often the indication for implantation than secondary prevention.²⁵ Only one study solely reported on patients with ICDs for primary prevention, showing that in the last 24 hours of life, 31% of patients experienced a shock.²² This is still high, which might be due to the fact that in this particular study, patients with known sustained VT were excluded from the study, and only a single zone of therapy was used, so no antitachycardia pacing (ATP) was allowed. Third, in recent years, advances have been made to further optimise ICD programming to minimise inappropriate and appropriate therapy.²⁶ Developments such as ATP, longer detection times and high rate cut-offs all contribute to a reduction in shock therapy, by allowing more time for the arrhythmia to terminate spontaneously.^26,27 These improvements in programming the ICD could mean that the current incidence of shocks might be lower than reported in the studies in this review. Fourth, studies we found were mainly concerned with patients dying of cardiac diseases, which might be an explanation for the high incidences as well. Only two studies specifically reported shock incidences on patients dying of noncardiac causes. Incidence in these populations seem to be lower than in the populations of NSD and SD patients.

Few studies were conducted on the impact of ICD shocks on patients in the last phase of life, their relatives and professional caregivers. From the literature on patients in earlier stages in their disease, it is known that shocks are painful and are associated with a diminished self-reported physical, emotional and social functioning, and symptoms of anxiety.²⁸ Although we found little detailed information on the impact of shocks in the last phase of life, this could also be the case in dying patients. In order to promote a peaceful death, quality of life should be pursued and the risk of developing symptoms of anxiety and depression should be reduced to a minimum. Timely deactivation of the ICD could help in promoting this peaceful death.

Communication between the professional caregiver and patient might be an important factor in preventing unwanted shocks at the end of life by deactivating the ICD. It has been shown that, when deactivation is discussed, a large proportion of patients decide to do so.⁸ However, these conversations are rare.^29,30 Professional caregivers often struggle with these conversations, because they feel they have insufficient knowledge about end of life care,³¹ they feel uncomfortable discussing the topic,³² or because they think talking about deactivation would take away hope from the patient.³³ A stronger collaboration with palliative care professionals might help professional caregivers to feel less uncomfortable initiating discussions about end of life.^34,35 Also, policies can be developed for caregivers who do not frequently attend ICD patients, explaining the importance of discussing and deactivating the ICD, with specific opening questions to address the topic.^1,36,37

More attention should be paid to inform the patient about the possibility of ICD deactivation, preferably starting before implantation of the device. Such discussions should be tailored to the patients’ health literacy, communication style and personal values. Physicians and nurses should be trained to obtain the necessary skills to discuss delicate end-of-life issues, such as possible deactivation of ICDs.³⁸

This study has some limitations. As with any review, it is possible that relevant studies were missed in conducting the search. In addition, publication bias is a possible limitation as well, leading to finding only articles which show notable results.⁷ Also, included studies had relatively small study populations, only three included more than 100 participants.^11,12,23 Further, seven of the 13 included studies on shock incidence were conducted 20 years or longer ago. Shock incidences might currently be lower than reported in this review, as described above. Finally, the majority of the studies were conducted in the USA, which might reduce the generalisability to a European population.

Future research on ICD management in the last phase of life should focus on determining shock incidences in both patients dying of noncardiac causes and patients dying with ICDs implanted for primary prevention, since these are not well known. Also, few studies are conducted on the impact of shocks at the end of life on patients, relatives and professional caregivers. This is a topic to be further examined. Also, it should be further examined what can be done to promote discussions before implantation and in early stages of the disease.

Conclusions

This is the first integrated review on the incidence and impact of ICD shocks in the last phase of life, providing a thorough overview of all the available evidence on these topics. Shocks were found to occur commonly, both in patients dying non-suddenly and patients dying suddenly. Shocks are painful and distressing for patients, but also distressing to witness for relatives and professional caregivers. The evidence summarised in this review should raise awareness among healthcare professionals of the negative consequences of having an active ICD at the end of life. Our findings emphasise that it is important for healthcare professionals to discuss ICD deactivation with the patient in an early stage of the disease. This can contribute to a timely deactivation of the ICD, and therefore can minimise possible suffering due to shocks and help promote a calm and peaceful death.

Supplementary Material

Supplementary_Material, Supplementary_Material – The incidence and impact of implantable cardioverter defibrillator shocks in the last phase of life: An integrated review

Supplementary_Material, Supplementary_Material for The incidence and impact of implantable cardioverter defibrillator shocks in the last phase of life: An integrated review by Rik Stoevelaar, Arianne Brinkman-Stoppelenburg, Rohit E Bhagwandien, Rozemarijn L van Bruchem-Visser, Dominic AMJ Theuns, Agnes van der Heide and Judith AC Rietjens in European Journal of Cardiovascular Nursing

Footnotes

Acknowledgements

The authors would like to thank GB de Jonge, biomedical information specialist at the Erasmus MC University Medical Center Rotterdam, for helping with developing and conducting the search strategy for this review.

Implications for practice

At the end of life, a potentially significant proportion of implantable cardioverter defibrillator (ICD) patients experience shocks.

ICD shocks are painful and distressing for patients.

ICD shocks are distressing to witness for bystanders.

The topic of deactivation should be discussed in a timely manner, and frequently, to promote a calm and peaceful death.

Current incidence of shocks needs further study.

Declaration of conflicting interests

The authors declare that there is no conflict of interest.

Funding

This work was supported by the Netherlands Organization for Health Research and Development (grant number 80-84400-98-076).

References

Lampert

Hayes

Annas

et al . HRS expert consensus statement on the management of cardiovascular implantable electronic devices (CIEDs) in patients nearing end of life or requesting withdrawal of therapy. Heart Rhythm 2010; 7: 1008–1026.

McIlvennan

Allen

. Palliative care in patients with heart failure. BMJ 2016; 353: i1010.

Padeletti

Arnar

Boncinelli

et al . EHRA expert consensus statement on the management of cardiovascular implantable electronic devices in patients nearing end of life or requesting withdrawal of therapy. Europace 2010; 12: 1480–1489.

Raatikainen

Arnar

Zeppenfeld

et al . Statistics on the use of cardiac electronic devices and electrophysiological procedures in the European Society of Cardiology countries: 2014 Report from the European Heart Rhythm Association. Europace 2015; 17: i1–i75.

Priori

Blomstrom-Lundqvist

Mazzanti

et al . 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: The Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC). Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC). Eur Heart J 2015; 36: 2793–2867.

Thylen

Moser

Stromberg

et al . Concerns about implantable cardioverter-defibrillator shocks mediate the relationship between actual shocks and psychological distress. Europace 2016; 18: 828–835.

Moher

Liberati

Tetzlaff

et al . Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Med 2009; 6: e1000097.

Goldstein

Lampert

Bradley

et al . Management of implantable cardioverter defibrillators in end-of-life care. Ann Intern Med 2004; 141: 835–838.

Epstein

Carlson

Fogoros

et al . Classification of death in antiarrhythmia trials. J Am Coll Cardiol 1996; 27: 433–442.

10.

Hawker

Payne

Kerr

et al . Appraising the evidence: Reviewing disparate data systematically. Qual Health Res 2002; 12: 1284–1299.

11.

Pratt

Greenway

Schoenfeld

et al . Exploration of the precision of classifying sudden cardiac death: Implications for the interpretation of clinical trials. Circulation 1996; 93: 519–524.

12.

Grubman

Pavri

Shipman

et al . Cardiac death and stored electrograms in patients with third-generation implantable cardioverter-defibrillators. J Am Coll Cardiol 1998; 32: 1056–1062.

13.

Lehmann

Thomas

Nabih

et al . Sudden death in recipients of first-generation implantable cardioverter defibrillators: Analysis of terminal events. Participating investigators. J Interv Cardiol 1994; 7: 487–503.

14.

Mosteller

Lehmann

Thomas

et al . Operative mortality with implantation of the automatic cardioverter-defibrillator. Am J Cardiol 1991; 68: 1340–1345.

15.

Pires

Hull

Nino

et al . Sudden death in recipients of transvenous implantable cardioverter defibrillator systems: Terminal events, predictors, and potential mechanisms. J Cardiovasc Electrophysiol 1999; 10: 1049–1056.

16.

Nielsen

Mortensen

Pedersen

. Long-term follow-up of patients treated with implantable cardioverter defibrillators in a Danish centre: Occurrence of ICD therapy and patient survival. Scand Cardiovasc J 1997; 31: 151–156.

17.

Gross

Zilo

Ferrick

et al . Sudden death mortality in implantable cardioverter defibrillator patients. Pacing Clin Electrophysiol 1991; 14: 250–254.

18.

Westerdahl

Sutton

Frykman

. Defibrillator patients should not be denied a peaceful death. Int J Cardiol 2015; 182: 440–446.

19.

Sherazi

McNitt

Aktas

et al . End-of-life care in patients with implantable cardioverter defibrillators: A MADIT-II substudy. PACE Pacing Clin Electrophysiol 2013; 36: 1273–1279.

20.

Westerdahl

Sjöblom

Mattiasson

et al . Implantable cardioverter-defibrillator therapy before death: High risk for painful shocks at end of life. Circulation 2014; 129: 422–429.

21.

Lewis

Luebke

Johnson

et al . Withdrawing implantable defibrillator shock therapy in terminally ill patients. Am J Med 2006; 119: 892–896.

22.

Poole

Johnson

Hellkamp

et al . Prognostic importance of defibrillator shocks in patients with heart failure. N Engl J Med 2008; 359: 1009–1017.

23.

Kelley

Reid

Miller

et al . Implantable cardioverter-defibrillator deactivation at the end of life: A physician survey. Am Heart J 2009; 157: 702–8.e1.

24.

Fromme

Stewart

Jeppesen

et al . Adverse experiences with implantable defibrillators in Oregon hospices. Am J Hospice Palliative Med 2011; 28: 304–309.

25.

European Heart Rhythm Association, Heart Rhythm Society, Zipes

et al . ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: A report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death). J Am Coll Cardiol 2006; 48: e247–e346.

26.

Kloppe

Proclemer

Arenal

et al . Efficacy of long detection interval implantable cardioverter-defibrillator settings in secondary prevention population: Data from the Avoid Delivering Therapies for Nonsustained Arrhythmias in ICD Patients III (ADVANCE III) trial. Circulation 2014; 130: 308–314.

27.

Gasparini

Proclemer

Klersy

et al . Effect of long-detection interval vs standard-detection interval for implantable cardioverter-defibrillators on antitachycardia pacing and shock delivery: The ADVANCE III randomized clinical trial. JAMA 2013; 309: 1903–1911.

28.

Mark

Anstrom

Sun

et al . Quality of life with defibrillator therapy or amiodarone in heart failure. N Engl J Med 2008; 359: 999–1008.

29.

Hill

McIlfatrick

Taylor

et al . Implantable cardioverter defibrillator (ICD) deactivation discussions: Reality versus recommendations. Eur J Cardiovasc Nurs 2016; 15: 20–29.

30.

Marinskis

van Erven

Deactivation of implanted cardioverter-defibrillators at the end of life: Results of the EHRA survey. Europace 2010; 12: 1176–1177.

31.

Hjelmfors

Stromberg

Friedrichsen

et al . Communicating prognosis and end-of-life care to heart failure patients: A survey of heart failure nurses’ perspectives. Eur J Cardiovasc Nurs 2014; 13: 152–161.

32.

Sherazi

Daubert

Block

. Physicians’ preferences and attitudes about end-of-life care in patients with an implantable cardioverter-defibrillator. Mayo Clin Proc 2008; 83: 1139–1141.

33.

Goldstein

Mehta

Teitelbaum

et al . ‘It’s like crossing a bridge’ complexities preventing physicians from discussing deactivation of implantable defibrillators at the end of life. J Gen Intern Med 2008; 23: S2–S6.

34.

Hauptman

Swindle

Hussain

et al . Physician attitudes toward end-stage heart failure: A national survey. Am J Med 2008; 121: 127–135.

35.

Russo

. Original research: Deactivation of ICDs at the end of life: A systematic review of clinical practices and provider and patient attitudes. Am J Nurs 2011; 111: 26–35.

36.

Goldstein

Carlson

Livote

et al . Brief communication: Management of implantable cardioverter-defibrillators in hospice: A nationwide survey. Ann Intern Med 2010; 152: 296–209.

37.

Pedersen

Chaitsing

Szili-Torok

et al . Patients’ perspective on deactivation of the implantable cardioverter-defibrillator near the end of life. Am J Cardiol 2013; 111: 1443–1447.

38.

Rietjens

JAC

Sudore

Connolly

et al . Definition and recommendations for advance care planning: An international consensus supported by the European Association for Palliative Care. Lancet Oncol 2017; 18: e543–e551.

Supplementary Material

Please find the following supplemental material available below.

For Open Access articles published under a Creative Commons License, all supplemental material carries the same license as the article it is associated with.

For non-Open Access articles published, all supplemental material carries a non-exclusive license, and permission requests for re-use of supplemental material or any part of supplemental material shall be sent directly to the copyright owner as specified in the copyright notice associated with the article.

0.00 MB

0.01 MB