Continuous Subcutaneous Insulin Infusion in Adult Type 1 Diabetes Mellitus: Data from a Registry at the University Medical Centre Ljubljana,Slovenia

Abstract

OBJECTIVE: To evaluate the treatment indications, effectiveness and adverse events of continuous subcutaneous insulin infusion (CSII) in adults with type 1 diabetes mellitus using data from a registry at the University Medical Centre Ljubljana, Ljubljana, Slovenia. METHODS: The registry included patients with type 1 diabetes who had converted from multiple daily injection (MDI) to CSII. Patients with complete data sets covering a period of ≥ 3 years were included in the study (n = 184). Complications, glycaemic control and insulin dose during CSII were compared with data obtained during MDI. RESULTS: CSII resulted in significant reductions in glycosyated haemoglobin level and total daily insulin dose. The mean number of severe hypoglycaemic episodes during CSII was 0.17 per patient per year. CONCLUSIONS: Treatment of adults with type 1 diabetes mellitus by CSII can improve glycaemic control and reduce insulin requirements compared with MDI, however patient selection, education and continuous care are important parts of this therapy.