Osteopontin (OPN) plays a role in T cell-mediated immunity, but its involvement in Th2-associated allergic responses, especially asthma, has not been investigated. This cross-sectional case— control study was designed to determine whether serum OPN levels are elevated in asthma patients and whether these correlated with disease severity. Serum samples were obtained from patients with mild (n = 42), moderate (n = 48) and severe (n = 39) asthma, and 41 healthy control subjects. OPN protein concentrations were measured by enzyme-linked immunosorbent assay and were found to be significantly higher in all three asthma patient groups compared with healthy controls. There was no significant association between OPN concentration and disease severity. The data suggest a role for OPN in the pathogenesis of asthma. Further studies are needed to clarify the involvement of OPN in various aspects of asthma.
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