This study compared changes in intragastric pressure (IGP) in response to a gastric distension stimulus caused by air insufflation in 25 patients with non-erosive gastro-oesophageal reflux disease (NERD) and 34 healthy volunteers (controls). In four NERD patients, IGP responses were also measured before and after oral treatment with 10 mg rabeprazole daily for 2 weeks. The rate of increase in IGP at the start of insufflation was significantly higher in NERD patients than in controls. The time to appearance of symptoms (i.e. time to threshold) was significantly shorter in NERD patients than in controls. Direct measurement of IGP showed that visceral hypersensitivity and impaired fundal relaxation are both characteristic of NERD. Administration of rabeprazole led to a marked prolonging of time to threshold, indicating that treatment could alleviate this hypersensitivity.
SuzukiTHiranoMYamamotoY: Examination of visceral perception and gastric tone by gastric stimulation using air inflation during endoscopy. J Int Med Res2005; 33: 160–169.
2.
SuzukiTHiranoM: Measurement of changes in intragastric pressure during stimulation of the stomach by air inflation in case of functional dyspepsia and gastroesophageal disease: Trial of a new method of assessing gastric function. Can J Gastroenterol2005; 19 (suppl C): R168.
3.
SuzukiTKiraFNishimuraS: Intragastric pressure (IGP) measurement following air insufflation in patients with functional dyspepsia (FD)–Assessment of gastric function by administration of itopride hydrochloride. Ther Res2007; 28: 1717–1722 [in Japanese].
4.
SuzukiTHiranoMYamamotoY: Co-relationship between initial intragastric pressure gradient and symptom threshold during intragastric pressure measurement under air inflation. Jpn J Clin Exp Med2008; 85: 103–104 [in Japanese].
5.
SuzukiTNishimuraSSuyamaY: Efficacy of mosapride citrate in patients with functional dyspepsia assessed by intragastric pressure measurement under air inflation. Diagnosis and Treatment2008; 96: 989–991 [in Japanese].
6.
LindTHavelundTLundellL: On demand therapy with omeprazole for the long-term management of patients with heartburn without oesophagitis–a placebo-controlled randomized trial. Aliment Pharmacol Ther1999; 13: 907–914.
7.
CarlssonRDentJWattsR: Gastro-oesophageal reflux disease in primary care: An international study of different treatment strategies with omeprazole. Eur J Gastroenterol Hepatol1998; 10: 119–124.
8.
FassR: Epidemiology and pathophysiology of symptomatic gastroesophageal reflux disease. Am J Gastroenterol2003; 98 (3 suppl): S2–S7.
9.
IshizakiTHoraiY: Review article: Cytochrome P450 and the metabolism of proton pump inhibitors–emphasis on rabeprazole. Aliment Pharmacol Ther1999; 13 (suppl 3): 27–36.
10.
CaosAMoskovitzMDayalY: Rabeprazole for the prevention of pathologic and symptomatic relapse of erosive or ulcerative gastroesophageal reflux disease. Am J Gastroenterol2000; 95: 3081–3088.
11.
ThjodleifssonBRindiGFioccaR: A randomized double-blind trial of the efficacy and safety of 10 or 20 mg rabeprazole compared with 20 mg omeprazole in the maintenance of gastro-oesophageal reflux disease over 5 years. Aliment Pharmacol Ther2003; 17: 343–351.
12.
NaganoKKuboMGotoM: The diagnosis of GERD: A study of a questionnaire (QUEST) for patients complaining of upper gastrointestinal symptoms. J New Remedies Clinics1998; 47: 841–851 [in Japanese].
13.
CarlssonRDentJBolling-SternevaldE: The usefulness of a structured questionnaire in the assessment of symptomatic gastroesophageal reflux disease. Scand J Gastroenterol1998; 33: 1023–1029.
14.
KusanoMShimoyamaYSugimotoS: Development and evaluation of FSSG: Frequency scale for the symptoms of GERD. J Gastroenterol2004; 39: 888–891.
15.
TackJCaenepeelPFischlerB: Symptoms associated with hypersensitivity to gastric distension in functional dyspepsia. Gastroenterology2001; 121: 526–535.
16.
CuomoRVandaelePCoulieB: Influence of motilin on gastric fundus tone and on meal-induced satiety in man: Role of cholinergic pathways. Am J Gastroenterol2006; 101: 804–811.
17.
TackJDemedtsIDehondtG: Clinical and pathophysiological characteristics of acute-onset functional dyspepsia. Gastroenterology2002; 122: 1738–1747.
18.
GeeraertsBVandenbergheJvan OudenhoveL: Influence of experimentally induced anxiety on gastric sensorimotor function in humans. Gastroenterology2005; 129: 1437–1444.
19.
AnjikiHSanakaMKuyamaY: Dual effects of rabeprazole on solid-phase gastric emptying assessed by the 13C-octanoate breath test. Digestion2005; 72: 189–194.
20.
SanakaMAnjikiHYamamotoT: Rabeprazole delays gastric emptying of a nutrient liquid. J Gastroenterol Hepatol2007; 22: 1806–1809.
LeeKJVosRJanssensJ: Influence of duodenal acidification on the sensorimotor function of the proximal stomach in humans. Am J Physiol Gastrointest Liver Physiol2004; 286: G278–G284.
