The Impact of Early Diastolic Myocardial Relaxation on the other Parameters of Diastolic Function and Association of Tissue Doppler Parameters of Diastolic Function with Diabetes Compensation and Duration in Type 2 Diabetic Patients

Abstract

This study assessed the impact of tissue Doppler derived myocardial early diastolic relaxation velocity (E_m) on the other parameters of diastolic function (preload dependent transmitral early diastolic velocity [E], tissue Doppler derived myocardial late diastolic velocity [A_m], preload dependent transmitral late diastolic velocity [A]) and evaluated the correlation of these parameters with selected clinical variables in type 2 diabetic patients. Using tissue Doppler echocardiography, 82 type 2 diabetic patients were evaluated, divided into two equal groups of E_m < 7.5 cm/s or ≥ 7.5 cm/s. Patients with E_m < 7.5 cm/s had significantly lower E/A and E_m/A_m, and higher E/E_m values. Multilinear regression showed a negative correlation between E_m and glycated haemoglobin (Hb_A1c) and duration of diabetes, a negative correlation of E_m/A_m with age, duration of diabetes and Hb_A1c, and a positive correlation of E/E_m with age, duration of diabetes and use of diuretics. The E/A ratio only correlated negatively with age. It is concluded that E_m is a reliable parameter of diastolic function, and that the tissue Doppler parameters of diastolic function are associated with diabetes compensation and diabetes duration.

Keywords

Diabetes mellitus Diastolic function Tissue Doppler echocardiography

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