We investigated the incidence and severity of echocardiographic and clinical abnormalities in patients with psoriasis and their relationship to the severity, duration and type of psoriasis and other related factors. A total of 216 psoriasis patients and 216 control subjects were included in this study. Left and right heart dimensions, wall thicknesses, wall motion abnormalities, valvular disturbances, and systolic and diastolic functions were examined using two-dimensional and Doppler echocardiographic techniques. Left ventricular hypertrophy, left ventricular diastolic dysfunction, left ventricular wall motion abnormalities and valvular pathologies, especially mitral and tricuspid valve prolapse, were significantly more frequent in patients with psoriasis. Systolic and diastolic blood pressures were significantly higher in psoriasis patients. Significant correlations were found between: (i) psoriasis vulgaris and tricuspid valve prolapse; (ii) palmo-plantar psoriasis and valvular pathologies; and (iii) disease duration and left ventricular diastolic dysfunction and systolic and diastolic blood pressures. Physicians should be aware that cardiovascular abnormalities are common in patients with psoriasis.
ChristophersEMrowietzU: Psoriasis: In: Fitzpatrick's Dermatology in General Medicine (FreedbergIMEisenAZWolffKAustenKFGoldsmithLAKatzSI, eds). New York: McGraw Hill, 2003; pp407–427.
3.
WinchesterR: Psoriatic arthritis. In: Fitzpatrick's Dermatology in General Medicine (FreedbergIMEisenAZWolffKAustenKFGoldsmithLAKatzSI, eds). New York: McGraw Hill, 2003; pp427–436.
4.
PearceDJMorrisonAEHigginsKBCraneMMBalkrishnanRFleischerAB: The co-morbid state of psoriasis patients in a university dermatology practice. J Dermatol Treat2005; 16: 319–323.
5.
InerotAEnerbackCEnlundFMartinssonTSamuelssonLWahlstromJ: Collecting a set of psoriasis family material through a patient organisation; clinical characterization and presence of additional disorders. BMC Dermatol2005; 5:10.
6.
HenselerTChristophersE: Disease concomitance in psoriasis. J Am Acad Dermatol1995; 32: 92–96.
7.
GuvenASasmazSAksuECaglayanCE: Echocardiographic evaluation in patients with psoriasis. T Klin J Cardiol2003; 16: 77–81.
8.
SaricaogluHGulluluSBaskanE BulbulCordanJTunaliS: Echocardiographic finding in subjects with psoriatic arthropathy. J Eur Acad Dermatol Venereol2003; 17: 414–417.
9.
BadokinVVKotel'NikovaGP: The heart damage in patients with psoriatic arthritis (in Russian, English abstract). Ter Arkh2004; 76: 56–61.
10.
KakturskiiLBBelovaEBPolosovaTASkatnikovaVI: Cardiac lesion in psoriasis (in Russian, English abstract). Arkh Patol2004; 66: 22–24.
11.
Wojas-PelcARajzerLRajzerM: Psoriasis and cardiovascular disorders (in Polish, English abstract). Przegl Lek2002; 59: 844–847.
12.
CheitlinMDAlpertJSArmstrongWFAurigemmaGPBellerGABiermanFZ: ACC/AHA Guidelines for the Clinical Application of Echocardiography: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Clinical Application of Echocardiography). Developed in collaboration with the American Society of Echocardiography. Circulation1997; 95: 1686–1744.
13.
GottdienerJSBednarzJDevereuxRGardinJKleinAManningWJ: American Society of Echocardiography recommendations for use of echocardiography in clinical trials. J Am Soc Echocardiogr2004; 10: 1086–1119.
14.
LangRMBierigMDevereuxRBFlachskampfFAFosterEPellikkaPA: Recommendations for chamber quantification: A report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr2005; 18: 1440–1463.
15.
QuinonesMAOttoCMStoddardMWaggonerAZoghbiWA; Doppler Quantification Task Force of the Nomenclature and Standards Committee of the American Society of Echocardiography: Recommendations for quantification of Doppler echocardiography: A report from the Doppler Quantification Task Force of the Nomenclature and Standards Committee of the American Society of Echocardiography. J Am Soc Echocardiogr2002; 15: 167–184.
RollerDHMunaWFRossAM: Psoriasis, sacroiliitis and aortitis: An echocardiographic mimic of aortic root dissection. Chest1979; 75: 641–643.
18.
MunaWFRollerDHCraftJShawRKRossAM: Psoriatic arthritis and aortic regurgitation. JAMA1980; 244: 363–365.
19.
TorokLTothEBruncsakA: Correlation between psoriasis and cardiovascular diseases (in German, English abstract). Z Hautkr1982; 57: 734–739.
20.
FukuharaKUranoYAkaikeMAhsanKAraseS: Psoriatic arthritis associated with dilated cardiomyopathy and Takayasu's arteritis. Br J Dermatol1998; 138: 329–333.
21.
SwedbergKClelandJDargieHDrexlerHFollathFKomajdaM; Task Force for the Diagnosis and Treatment of Chronic Heart Failure of the European Society of Cardiology. Guidelines for the diagnosis and treatment of chronic heart failure: Executive summary (update 2005): The Task Force for the Diagnosis and Treatment of Chronic Heart Failure of the European Society of Cardiology. Eur Heart J2005; 26: 1115–1140.
22.
KannelWB: Left ventricular hypertrophy as a risk factor: The Framingham experience. J Hypertens Suppl1991; 9: S3–S8.
23.
HaiderAWLarsonMGBenjaminEJLevyD: Increased left ventricular mass and hypertrophy are associated with increased risk for sudden death. J Am Coll Cardiol1998; 32: 1454–1459.
24.
PrioriSGAliotEBlomstrom-LundqvistCBossaertLBreithardtGBrugadaP: Task Force on Sudden Cardiac Death of the European Society of Cardiology. Eur Heart J2001; 22: 1374–1450.
25.
AhmedQChung-ParkMMustafaKKhanMA: Psoriatic spondyloarthropathy with secondary amyloidosis. J Rheumatol1996; 23: 1107–1110.
Rocha-PereiraPSantos-SilvaARebeloIFigueiredoAQuintanilhaATeixeiraF: Dislipidemia and oxidative stress in mild and in severe psoriasis as a risk for cardiovascular disease. Clin Chim Acta2001; 303: 33–39.
28.
KuralB VanizorOremACimsitGYandıYECalapogluM: Evaluation of the atherogenic tendency of lipids and lipoprotein content and their relationships with oxidant-antioxidant system in patients with psoriasis. Clin Chim Acta2003; 328: 71–82.
