Enhanced Effects of Combined Bu-Zhong-Yi-Qi-Tang (TJ-41) and Interleukin-18 on the Production of Tumour Necrosis Factor-α and Interferon-γ in Human Peripheral Blood Mononuclear Cells
Free accessResearch articleFirst published online February, 2004
Enhanced Effects of Combined Bu-Zhong-Yi-Qi-Tang (TJ-41) and Interleukin-18 on the Production of Tumour Necrosis Factor-α and Interferon-γ in Human Peripheral Blood Mononuclear Cells
Co-stimulatory molecules play important roles in immune responses. We investigated the effect of Bu-Zhong-Yi-Qi-Tang (TJ-41) on the expression of intercellular adhesion molecule-1 (ICAM-1), B7.1 and B7.2 by peripheral blood mononuclear cells stimulated by interleukin-18 (IL-18) using fluorescence-activated cell sorter analysis. TJ-41 increased IL-18-induced ICAM-1 and B7.2 expression, resulting in enhanced production of tumour necrosis factor-a and interferon-g. These results suggest that TJ-41 enhances IL-18-induced cell-mediated immunity and may enhance host defence mechanisms against pathogens.
KubotaAOkamuraSShimodaKHaradaNOmoriFNihoY: A traditional Chinese herbal medicine, Juzen-Taiho-To, augments the production of granulocyte/macrophage colony-stimulating factor from human peripheral blood mononuclear cells in vitro (in Japanese). Int J Immunother1992; 8: 191–195
2.
MizoguchiYSakagamiYKiokaKMorisawaS: Effect of Shi-Quan-Da-Bu-Tang on the immune system (in Japanese). Pharma Medica1988; 2: 38–42
3.
TerawakiKNoseMOgiharaY: The effects of crude polysaccharide fractions of 4 kinds of kampo-hozai administered orally on nitric oxide production by murine peritoneal macrophages. Biol Pharm Bull1997; 20: 809–811
4.
KawamataHOchiaiHMantaniNTerasawaK: Enhanced expression of inducible nitric oxide synthase by Juzen-taiho-to in LPS-activated RAW264.7 cells, a murine macrophage cell line. Am J Chin Med2000; 28: 217–226
5.
YamaokaYKawakitaTNomotoK: Protective effect of a traditional Japanese medicine, Buzhong-yi-qi-tang (Japanese name: Hochu-ekki-to), on the restraint stress-induced susceptibility against Listeria monocytogenes.. Immunopharmacology2000; 48: 35–42
6.
ShimizuSKomatsuYWangXX: Immunomodulating activity of Hochu-ekki-to against mouse model for enterohemorrhagic Escherichia coli infection (in Japanese). Jpn J Oriental Med1998; 49: 429–439
7.
ShimizuSOhdoiCHujitaRYamaguchiN: Effect of Juzen-taiho-to on Salmonella infection of tumor-bearing mice (in Japanese). JAMA Japan1996; 17: 16–17
8.
YamaguchiNWannXXOgataYShimizuS: Effect of Hozai on the protection against infection with bacteria (in Japanese). Prog Med1999; 19: 986–991
9.
MitaYDobashiKShimizuYNakazawaTMoriM: Surface expression of toll-like receptor 4 on THP-1 cells is modulated by Bu-Zhong-Yi-Qi-Tang and Shi-Quan-Da-Bu-Ttang. Methods Find Exp Clin Pharmacol2002; 24: 67–70
10.
MeansTKGolenbockDTFentonMJ: The biology of Toll-like receptors. Cytokine Growth Factor Rev2000; 11: 219–232
11.
QureshiSTLariviereLLevequeGClermontSMooreKJGrosP: Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4). J Exp Med1999; 189: 615–625
MitaYDobashiKNakazawaTMoriM: Induction of Toll-like receptor 4 in granulocytic and monocytic cells differentiated from HL-60 cells. Br J Haematol2001; 112: 1041–1047
14.
MitaYDobashiKShimizuYNakazawaTMoriM: Toll-like receptor 2 and 4 surface expressions on human monocytes are modulated by interferon-gamma and macrophage colony-stimulating factor. Immunol Lett2001; 78: 97–101
15.
HermannPRubioMNakajimaTDelespesseGSarfatiM: IFN-alpha priming of human monocytes differentially regulates grampositive and gram-negative bacteria-induced IL-10 release and selectively enhances IL-12p70, CD80, and MHC class I expression. J Immunol1998; 161: 2011–2018
16.
AsakuraEHanamuraTUmemuraAYadaKYamauchiTTanabeT: Effect of macrophage colony-stimulating factor (M-CSF) on lipopolysaccharide (LPS)-induced mediator production from monocytes in vitro.Immunobiology1996; 195: 300–313
17.
HashimotoSYamadaMMotoyoshiKAkagawaKS: Enhancement of macrophage colony-stimulating factor-induced growth and differentiation of human monocytes by interleukin-10. Blood1997; 89: 315–321
18.
HershmanMJPolkHCJrPietschJDKuftinecDSonnenfeldG: Modulation of Klebsiella pneumoniae infection of mice by interferon-gamma. Clin Exp Immunol1988; 72: 406–409
19.
HershmanMJSonnenfeldGLoganWAPietschJDWellhausenSRPolkHCJr: Effect of interferon-gamma treatment on the course of a burn wound infection. J Interferon Res1988; 8: 367–373
20.
KayashimaSTsuruSShinomiyaNKatsuraYMotoyoshiKRokutandaM: Effects of macrophage colony-stimulating factor on reduction of viable bacteria and survival of mice during Listeria monocytogenes infection: characteristics of monocyte subpopulations. Infect Immun1991; 59: 4677–4680
21.
GregorySHWingEJTweardyDJShadduckRKLinHS: Primary listerial infections are exacerbated in mice administered neutralizing antibody to macrophage colony-stimulating factor. J Immunol1992; 149: 188–193
22.
OkamuraHTsutsuiHKomatsuTYutsudoMHakuraATanimotoT: Cloning of a new cytokine that induces IFN-γ production by T cells. Nature1995; 378: 88–91
23.
KohnoKKataokaJOhtsukiTSuemotoYOkamotoIUsuiM: IFN-γ-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12. J Immunol1997; 158: 1541–1550
24.
AhnHJMaruoSTomuraMMuJHamaokaTNakanishiK: A mechanism underlying synergy between IL-12 and IFN-γ-inducing factor in enhanced production of IFN-γ. J Immunol1997; 159: 2125–2131
25.
TakedaKTsutsuiHYoshimotoTAdachiOYoshidaNKishimotoT: Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity1998; 8: 383–390
26.
BarbulescuKBeckerCSchlaakJFSchmittEMeyer zum BuschenfeldeKHNeurathMF: IL-12 and IL-18 differentially regulate the transcriptional activity of the human IFN-γ promoter in primary CD4+ T lymphocytes. J Immunol1998; 160: 3642–3647
27.
UnanueER: Antigen-presenting function of the macrophage. Annu Rev Immunol1984; 2: 395–428
28.
ValituttiSDessingMAktoriesKGallatiHLanzavecchiaA: Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton. J Exp Med1995; 181: 577–584
29.
YoshidaATakahashiKHNishiboriMIwagakiHYoshinoTMorichikaT: IL-18-induced expression of intercellular adhesion molecule-1 in human monocytes: involvement in IL-12 and IFN-γ production in PBMC. Cell Immunol2001; 210: 106–115
30.
KohkaHYoshinoTIwagakiHSakumaITanimotoTMatsuoY: Interleukin-18/ interferon-γ-inducing factor, a novel cytokine, up-regulates ICAM-1 (CD54) expression in KG-1 cells. J Leukocyte Biol1998; 64: 519–527
31.
YoshimotoTTakedaKTanakaTOhkusuKKashiwamuraSOkamuraH: IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production. J Immunol1998; 161: 3400–3407
32.
ChangJTSegalBMNakanishiKOkamuraHShevachEM: The costimulatory effect of IL-18 on the induction of antigen-specific IFN-gamma production by resting T cells is IL-12 dependent and is mediated by up-regulation of the IL-12 receptor beta2 subunit. Eur J Immunol2000; 30: 1113–1119
33.
YoshidaATakahashiH KohkaIwagakiHYoshinoTMorichikaTYokoyamaM: Essential role of ICAM-1/LFA-1 interaction in synergistic effect of IL-18 and IL-12 on IFN-gamma production in human PBMC. Naunyn Schmiedebergs Arch Pharmacol2002; 365: 181–186
34.
PaikYHSchwabeRFBatallerRRussoMPJobinCBrennerDA: Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Hepatology2003; 37: 1043–1055
35.
KyburzDRethageJSeiblRLauenerRGayRECarsonDA: Bacterial peptidoglycans but not CpG oligodeoxynucleotides activates synovial fibroblasts by toll-like receptor signaling. Arthritis Rheum2003; 48: 642–650
36.
ZeukeSUlmerAJKusumotoSKatusHAHeineH: TLR4-mediated inflammatory activation of human coronary artery endothelial cells by LPS. Cardiovasc Res2002; 56: 126–134
37.
MicallefMJDarmaninSBuhagiarJACamilleri-PodestaMTYamauchiHKurimotoM: Interferon gamma induction in human melanoma cell/allogeneic leukocyte co-cultures is enhanced by interleukin 18 but drug resistant melanoma cells are poorer inducers of IFN-gamma. Int Immunopharmacol2001; 1: 295–305
38.
OkanoFYamadaK: Canine interleukin-18 induces apoptosis and enhances Fas ligand mRNA expression in a canine carcinoma cell line. Anticancer Res2000; 20: 3411–3415
